DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tre1 and GPR84

DIOPT Version :9

Sequence 1:	NP_001284901.1	Gene:	Tre1 / 140439	FlyBaseID:	FBgn0046687	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_065103.1	Gene:	GPR84 / 53831	HGNCID:	4535	Length:	396	Species:	Homo sapiens

Alignment Length:	416	Identity:	107/416 - (25%)
Similarity:	173/416 - (41%)	Gaps:	103/416 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 ATQSIYPHSATL---FAAISACVFVTI-GVLGNLITLLALLKSPTIREHATTAF---VISLSISD 82
            |..|.| |.:.|   :.|:|..|.|.: |.:||::|||||...|.:|    |.|   :.:|:::|
Human     7 ANFSCY-HESVLGYRYVAVSWGVVVAVTGTVGNVLTLLALAIQPKLR----TRFNLLIANLTLAD 66

  Fly    83 LLFCSFSLPLTAVRFFQESWTFGTTLCKIFPVIFYGNVAVSLLSMVGITLNRYILIACHSRYSQI 147
            ||:|:...|.:...:....|..|.|.|::|.::.:.:.:||:|::..|.|.||:|||....:.|:
Human    67 LLYCTLLQPFSVDTYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQV 131

  Fly   148 YKPKFITLQLLFVWAVSFLLLLPPILGIWGEMGLDEATFSCTILKKEGRSIKKTLFVIGFLLPCL 212
            :..|.|.|.|:..|.|......|    :|....|.....:|:..:..||.....|..|.|:|...
Human   132 FSAKGIVLALVSTWVVGVASFAP----LWPIYILVPVVCTCSFDRIRGRPYTTILMGIYFVLGLS 192

  Fly   213 VIIVSYSCIYITV-----------LHQKKKIRNH---------DNFQ------------------ 239
            .:.:.|..|:..|           |.|.....||         ..||
Human   193 SVGIFYCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQELDSRLASGGPSEGISSE 257

  Fly   240 -IAAA-----KGSSSSGGGSYMTTTCTRKAR------------------------EDNRLTVMMV 274
             ::||     :|.||..|....:....:.|.                        |..::|.|..
Human   258 PVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEASAKAQPIKGARRAPDSSSEFGKVTRMCF 322

  Fly   275 TIFLCFLVCFLPLMLANVVDDERNTSYPWLHIIASVMAWASSVINPIIYAASNRNYSESIFYFRV 339
            .:||||.:.::|.:|.|:: |.|..:...:|::|:.:.|.:..|||::|||.||.       ||.
Human   323 AVFLCFALSYIPFLLLNIL-DARVQAPRVVHMLAANLTWLNGCINPVLYAAMNRQ-------FRQ 379

  Fly   340 AYYKIFALLKFWGEPLSPMPSRNYHQ 365
            ||          |..|...| |::|:
Human   380 AY----------GSILKRGP-RSFHR 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tre1	NP_001284901.1	7tm_1	52..323	CDD:278431	83/341 (24%)
GPR84	NP_065103.1	7tmA_GPR84-like	21..381	CDD:320338	95/375 (25%)
		TM helix 1	22..48	CDD:320338	12/25 (48%)
		TM helix 2	55..78	CDD:320338	7/22 (32%)
		TM helix 3	93..123	CDD:320338	10/29 (34%)
		TM helix 4	137..155	CDD:320338	6/21 (29%)
		TM helix 5	175..200	CDD:320338	7/24 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	244..311		7/66 (11%)
		TM helix 6	312..342	CDD:320338	10/30 (33%)
		TM helix 7	349..374	CDD:320338	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	129	1.000	Domainoid score	I5270
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H41370
Inparanoid	1	1.050	148	1.000	Inparanoid score	I4406
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45279
OrthoDB	1	1.010	-	-		D321514at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42286
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4597
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	8.010