Protein Alignment Tre1 and Gpr75

DIOPT Version :10

• Sequence 1: NP_001284901.1
• Gene: Tre1 / 140439
• FlyBaseID: FBgn0046687
• Length: 399
• Species: Drosophila melanogaster
• Sequence 2: NP_001102566.1
• Gene: Gpr75 / 498434
• RGDID: 1566385
• Length: 540
• Species: Rattus norvegicus
• Alignment Length: 443
• Identity: 96/443 - (21%)
• Similarity: 158/443 - (35%)
• Gaps: 114/443 - (25%)

  Fly    32 HSATLF-AAISACVFVTIGVLGNLITLLALLKSPTIREHATT--AFVISLSISDLLFCSFSLPL- 92
            |:|||. ..:...:...:|..||.|..|:.. .|..|:..|.  ..:::||..||..|..:.|:
  Rat    38 HTATLVTCTVLLAIIFCLGSYGNFIVFLSFF-DPAFRKFRTNFDFMILNLSFCDLFICGATAPMF 101

  Fly    93 TAVRFFQESWTFGTTLCKIFPVIFYGNVAVSLLSMVGITLNRYILIA-----CHSRYSQIYKPKF 152
            |.|.||..:.:...:.|..|.:...|.:.:||..:..|.|:|..::.     |.:.:|      .
  Rat   102 TFVLFFSSARSIPDSFCFTFHLTSSGFIIMSLKMVAVIALHRLRMVMGKQPNCTASFS------C 160

  Fly   153 ITLQLLFVWAVSFLLLLPPILGIWGEMGLDEATFS---------C----TILKKEGRSIKKTLFV 204
            |.|..|.:||.||.|                ||.:         |    :::..||::| .:|:|
  Rat   161 ILLLTLLLWATSFTL----------------ATLATLRTSKSHLCLPMSSLMDGEGKAI-LSLYV 208

  Fly   205 IGFLLPCLVIIVSYSCIYITVLH--QKKK---IRNHDNFQIAAAKGSSSSGGGSYMTTTC----- 259
            :.|.....|:.|||..|..|:..  |.||   :...|..:.....|:|..|.|..:..|.
  Rat   209 VDFTFCVAVVSVSYIMIAQTLRKNAQVKKCPPVITVDASRPQPFMGASVKGNGDPIQCTMPALYR 273

  Fly   260 ---------------TRKARE---------------------DNRLTVMMVTIFLCFLVCFLPL- 287
                           |:.|.:                     |::..|..:.|.|..|||.|||
  Rat   274 NQNYNKLQHNQTHGYTKNANQMPIPSASRLQLVSAVNLSTAKDSKAVVTCMVIVLSVLVCCLPLG 338

  Fly   288 --MLANVVDDERNTSYPWLHIIASVMAWASSVINPIIYAASNRNYSESIFYFRVAYYKIFALLKF 350
              :|..|:.|..:.......:....:.:..|.:||.||:.::.....          |:...|::
  Rat   339 ISLLQVVLSDSGSFILYQFELFGFTLIFFKSGLNPFIYSRNSAGLRR----------KVLWCLRY 393

  Fly   351 WG---------EPLSPMPSRNYHQSKNSKELSGVIRSTPLFHAVQKNSINQMC 394
            .|         ..|..|...|...::|.........:..|....||..::|.|
  Rat   394 TGLGFLCCKQKTRLRAMGKGNLEINRNKSSHHETNSAYMLSPKPQKKFVDQAC 446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tre1	NP_001284901.1	7tmA_GPR84-like	37..341	CDD:320338	80/374 (21%)
		TM helix 1	37..63	CDD:320338	5/26 (19%)
		TM helix 2	71..94	CDD:320338	7/25 (28%)
		TM helix 3	109..139	CDD:320338	8/29 (28%)
		TM helix 4	153..171	CDD:320338	8/17 (47%)
		TM helix 5	195..220	CDD:320338	9/24 (38%)
		TM helix 6	264..294	CDD:320338	12/53 (23%)
		TM helix 7	302..327	CDD:320338	5/24 (21%)
Gpr75	NP_001102566.1	7tmA_GPR75	44..387	CDD:320136	80/376 (21%)
		TM helix 1	44..70	CDD:320136	5/26 (19%)
		TM helix 2	79..104	CDD:320136	7/24 (29%)
		TM helix 3	118..148	CDD:320136	8/29 (28%)
		TM helix 4	159..181	CDD:320136	11/43 (26%)
		TM helix 5	199..228	CDD:320136	11/29 (38%)
		TM helix 6	314..344	CDD:320136	11/29 (38%)
		TM helix 7	355..380	CDD:320136	5/24 (21%)