Protein Alignment Tre1 and NPY5R

DIOPT Version :10

• Sequence 1: NP_001284901.1
• Gene: Tre1 / 140439
• FlyBaseID: FBgn0046687
• Length: 399
• Species: Drosophila melanogaster
• Sequence 2: XP_011530317.1
• Gene: NPY5R / 4889
• HGNCID: 7958
• Length: 452
• Species: Homo sapiens
• Alignment Length: 455
• Identity: 101/455 - (22%)
• Similarity: 165/455 - (36%)
• Gaps: 170/455 - (37%)

  Fly    16 DMQMDE-----------PAAATQSIYP----HSATL----FAAISACVFVT-IGVLGNLITLLAL 60
            |:::||           .||...|.:|    :.:::    :..|....||: :|.:|||:.|:||
Human     9 DLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMAL 73

  Fly    61 LKSPTIREHATTA-FVI-SLSISDLLFCSFSLPLTAVRFFQESWTFGTTLCKIFPVIFYGNVAVS 123
            :|.   |...||. |:| :|:.||:|...|..|.|......:.|.||..:|.|.|.:...:|.||
Human    74 MKK---RNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVS 135

  Fly   124 LLSMVGITLNRYILI---------ACHSRYSQIYKPKFITLQLLFVWAVSFLLLLP-PILGIWGE 178
            .|.::.|.:.||.:|         |.|..:           .:..||.:.|.:..| |:.....|
Human   136 TLILISIAIVRYHMIKHPISNNLTANHGYF-----------LIATVWTLGFAICSPLPVFHSLVE 189

  Fly   179 MGLDEATFSCTILKKEGRSIKK------------TLFVIGFLLPCLVIIVSY-------SC---- 220
            :   :.||...:|......::.            :|.::.::||.:.:.||:       ||
Human   190 L---QETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSN 251

  Fly   221 ----------IYITVLHQKKK-----------------IRNH----------------------- 235
                      |.:| ||..||                 |:.|
Human   252 KENRLEENEMINLT-LHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENH 315

  Fly   236 -----DNFQIAAAKGSSSS----GGGSYMTTTCTRKAREDN------------------------ 267
                 :||....::.||||    |     ..||.....|:|
Human   316 SRILPENFGSVRSQLSSSSKFIPG-----VPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFY 375

  Fly   268 RLTVMMVTIFLCFLVCFLPLMLANVVDDER-----NTSYPWLHIIASVMAWASSVINPIIYAASN 327
            |||:::    |.|.|.::||.|.:||.|..     |..:..::.|..::...|..:|||:|...|
Human   376 RLTILI----LVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLN 436

  Fly   328  327
            Human   437  436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tre1	NP_001284901.1	7tmA_GPR84-like	37..341	CDD:320338	94/415 (23%)
		TM helix 1	37..63	CDD:320338	10/26 (38%)
		TM helix 2	71..94	CDD:320338	10/24 (42%)
		TM helix 3	109..139	CDD:320338	11/38 (29%)
		TM helix 4	153..171	CDD:320338	4/18 (22%)
		TM helix 5	195..220	CDD:320338	5/43 (12%)
		TM helix 6	264..294	CDD:320338	12/53 (23%)
		TM helix 7	302..327	CDD:320338	6/24 (25%)
NPY5R	XP_011530317.1	7tmA_NPY5R	49..443	CDD:320520	94/415 (23%)
		TM helix 1	50..76	CDD:320520	10/25 (40%)
		TM helix 2	83..108	CDD:320520	9/24 (38%)
		TM helix 3	121..151	CDD:320520	10/29 (34%)
		TM helix 4	162..183	CDD:320520	5/31 (16%)
		TM helix 5	215..244	CDD:320520	5/28 (18%)
		TM helix 6	368..398	CDD:320520	10/33 (30%)
		TM helix 7	411..436	CDD:320520	6/24 (25%)