Protein Alignment Tre1 and GPR25

DIOPT Version :10

• Sequence 1: NP_001284901.1
• Gene: Tre1 / 140439
• FlyBaseID: FBgn0046687
• Length: 399
• Species: Drosophila melanogaster
• Sequence 2: NP_005289.2
• Gene: GPR25 / 2848
• HGNCID: 4480
• Length: 361
• Species: Homo sapiens
• Alignment Length: 319
• Identity: 78/319 - (24%)
• Similarity: 129/319 - (40%)
• Gaps: 59/319 - (18%)

  Fly    31 PHSATLFAAISACVFVTIGVLGN--LITLLALLKSPTIREHATTAFVISLSISDLLFCSFSLPL- 92
            |:......|:....| .:|:|||  ::.|||..:.|   ......||:.|:.:||.|. .:|||
Human    36 PYGYVYIPALYLAAF-AVGLLGNAFVVWLLAGRRGP---RRLVDTFVLHLAAADLGFV-LTLPLW 95

  Fly    93 TAVRFFQESWTFGTTLCKIFPVIFYGNVAVSLLSMVGITLNRYILIACHSRYSQIYKPKFITLQL 157
            .|.......|.||..|||:......|......|.:.|::::||:.:........:..|:......
Human    96 AAAAALGGRWPFGDGLCKLSSFALAGTRCAGALLLAGMSVDRYLAVVKLLEARPLRTPRCALASC 160

  Fly   158 LFVWAVSFLLLLP--------PILGIWGEMGLDEATFSCTILKKEGRSIKKTLFVIGFLLPCLVI 214
            ..||||:.|..||        |:.|     |.|...........:|.|:  .|.::.|:||.:|.
Human   161 CGVWAVALLAGLPSLVYRGLQPLPG-----GQDSQCGEEPSHAFQGLSL--LLLLLTFVLPLVVT 218

  Fly   215 IVSYSCIYITVLHQKKKIRNHDNFQIAAAKGSS--------SSGGGSYMTTTCTRKAREDNRLTV 271
            :..|..|       .:::|...:  :..|:.:|        |:..||::..:..|......||..
Human   219 LFCYCRI-------SRRLRRPPH--VGRARRNSLRIIFAIESTFVGSWLPFSALRAVFHLARLGA 274

  Fly   272 MMVTIFLCFLVCFLPLMLANVVDDERNTSYPWLHIIASVMAWASSVINPIIYAASNRNY 330
            :.       |.|  ||:||          ..|...||:.:|:.:|..||:||...:|::
Human   275 LP-------LPC--PLLLA----------LRWGLTIATCLAFVNSCANPLIYLLLDRSF 314

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tre1	NP_001284901.1	7tmA_GPR84-like	37..341	CDD:320338	77/313 (25%)
		TM helix 1	37..63	CDD:320338	9/27 (33%)
		TM helix 2	71..94	CDD:320338	9/23 (39%)
		TM helix 3	109..139	CDD:320338	7/29 (24%)
		TM helix 4	153..171	CDD:320338	7/25 (28%)
		TM helix 5	195..220	CDD:320338	8/24 (33%)
		TM helix 6	264..294	CDD:320338	8/29 (28%)
		TM helix 7	302..327	CDD:320338	9/24 (38%)
GPR25	NP_005289.2	7tm_GPCRs	40..318	CDD:475119	77/315 (24%)
		TM helix 1	42..66	CDD:320321	8/24 (33%)
		TM helix 2	75..96	CDD:320321	9/21 (43%)
		TM helix 3	113..135	CDD:320321	4/21 (19%)
		TM helix 4	158..174	CDD:320321	6/15 (40%)
		TM helix 5	200..223	CDD:320321	7/24 (29%)
		TM helix 6	243..265	CDD:320321	3/21 (14%)
		TM helix 7	286..311	CDD:320321	9/24 (38%)