DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tre1 and GPR15

DIOPT Version :9

Sequence 1:	NP_001284901.1	Gene:	Tre1 / 140439	FlyBaseID:	FBgn0046687	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_005281.1	Gene:	GPR15 / 2838	HGNCID:	4469	Length:	360	Species:	Homo sapiens

Alignment Length:	323	Identity:	84/323 - (26%)
Similarity:	135/323 - (41%)	Gaps:	70/323 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 TQSIYPHSATLFAAISACVFVTIGVLGNLITLLALLKSPTIREHATTAFVISLSISDLLFCSFSL 90
            |.|..|:::.........||:| ||||||:.:.||...|..| .....|:|:|:.||.:|. .:|
Human    25 THSHVPYTSVFLPVFYTAVFLT-GVLGNLVLMGALHFKPGSR-RLIDIFIINLAASDFIFL-VTL 86

  Fly    91 PLTAVRFFQES---WTFGTTLCKIFPVIFYGNVAVSLLSMVGITLNRYILIACHSRYSQIYKPKF 152
            ||...:  :.|   |..|:.|||....:...|:..|:|.:..::::||:.|..     .:...||
Human    87 PLWVDK--EASLGLWRTGSFLCKGSSYMISVNMHCSVLLLTCMSVDRYLAIVW-----PVVSRKF 144

  Fly   153 ITLQLLFV-----WAVSFLLLLPPILGIWGEMGLDEATFSCTILKKEGRSIK----KTLFVIGFL 208
            ......:|     |.:|.||.||.:|.  .|:.|.:....|.  :|:...||    ....:..|.
Human   145 RRTDCAYVVCASIWFISCLLGLPTLLS--RELTLIDDKPYCA--EKKATPIKLIWSLVALIFTFF 205

  Fly   209 LPCLVIIVSYSCIYITVLHQKKKIRNHDNFQIAAAKGSSSSGGGSYMTTTCTRKAREDNRLTVMM 273
            :|.|.|:..|.||       .:|:..|  :|                     :..:.:.:|...:
Human   206 VPLLSIVTCYCCI-------ARKLCAH--YQ---------------------QSGKHNKKLKKSI 240

  Fly   274 VTIFL---CFLVCFLPL----MLANVVDDERNTSYPWLHI------IASVMAWASSVINPIIY 323
            ..||:   .|||.:||.    .|| :|...|...|....|      ::..:|:|:|.:||.||
Human   241 KIIFIVVAAFLVSWLPFNTFKFLA-IVSGLRQEHYLPSAILQLGMEVSGPLAFANSCVNPFIY 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tre1	NP_001284901.1	7tm_1	52..323	CDD:278431	73/295 (25%)
GPR15	NP_005281.1	7tmA_GPR15	34..313	CDD:320322	81/314 (26%)
		TM helix 1	35..61	CDD:320322	11/26 (42%)
		TM helix 2	68..93	CDD:320322	9/27 (33%)
		TM helix 3	106..136	CDD:320322	7/29 (24%)
		TM helix 4	150..168	CDD:320322	6/17 (35%)
		TM helix 5	192..221	CDD:320322	8/35 (23%)
		TM helix 6	234..264	CDD:320322	8/29 (28%)
		TM helix 7	281..306	CDD:320322	7/22 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24228
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100