DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tre1 and Gpr75

DIOPT Version :9

Sequence 1:	NP_001284901.1	Gene:	Tre1 / 140439	FlyBaseID:	FBgn0046687	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_780699.2	Gene:	Gpr75 / 237716	MGIID:	2441843	Length:	540	Species:	Mus musculus

Alignment Length:	485	Identity:	105/485 - (21%)
Similarity:	172/485 - (35%)	Gaps:	154/485 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 HSATLFAAISACVFV-----TIGVLGNLITLLALLKSPTIREHATT--AFVISLSISDLLFCSFS 89
            |:|||.    .|.|:     .:|..||.|..|:.. .|:.|:..|.  ..:::||..||..|..:
Mouse    38 HTATLV----TCTFLLAIIFCLGSYGNFIVFLSFF-DPSFRKFRTNFDFMILNLSFCDLFICGVT 97

  Fly    90 LPL-TAVRFFQESWTFGTTLCKIFPVIFYGNVAVSLLSMVGITLNRYILIA-----CHSRYSQIY 148
            .|: |.|.||..:.:...:.|..|.:...|.|.:||..:..|.|:|..::.     |.:.:|
Mouse    98 APMFTFVLFFSSASSIPDSFCFTFHLTSSGFVIMSLKMVAVIALHRLRMVMGKQPNCTASFS--- 159

  Fly   149 KPKFITLQLLFVWAVSFLLLLPPILGIWGEMGLDEATFS---------C----TILKKEGRSIKK 200
               .|.|..|.:||.||.|                ||.:         |    :::..||::| .
Mouse   160 ---CILLLTLLLWATSFTL----------------ATLATLRTNKSHLCLPMSSLMDGEGKAI-L 204

  Fly   201 TLFVIGFLLPCLVIIVSYSCIYITVLH--QKKK---IRNHDNFQIAAAKGSSSSGGGSYMTTTCT 260
            :|:|:.|.....|:.|||..|..|:..  |.||   :...|..:.....|:|..|.|.  ...||
Mouse   205 SLYVVDFTFCVAVVSVSYIMIAQTLRKNAQVKKCPPVITVDASRPQPFMGASVKGNGD--PIQCT 267

  Fly   261 RKA-------------------------------------------REDNRLTVMMVTIFLCFLV 282
            ..|                                           .:|::..|..|.|.|..||
Mouse   268 MPALYRNQNYNKLQHSQTHGYTKNINQMPIPSASRLQLVSAINFSTAKDSKAVVTCVVIVLSVLV 332

  Fly   283 CFLPL---MLANVVDDERNTSYPWLHIIASVMAWASSVINPIIYAASNRNYSESIF----YFRVA 340
            |.|||   ::..|:.|..:.......:....:.:..|.:||.||:.::......:.    |..:.
Mouse   333 CCLPLGISLVQMVLSDNGSFILYQFELFGFTLIFFKSGLNPFIYSRNSAGLRRKVLWCLRYTGLG 397

  Fly   341 YY--KIFALLKFWGE-------------------PLSPMPSRNY----------HQSKNSKELS- 373
            :.  |....|:..|:                   .|||.|.|.:          .:|..|.::|
Mouse   398 FLCCKQKTRLRAMGKGNLEINRNKSSHHETNSAYMLSPKPQRKFVDQACGPSHSKESAASPKVSA 462

  Fly   374 -----GVIRSTPL------FHAVQKNSINQ 392
                 |...|||:      ::::..:|.:|
Mouse   463 GHQPCGQSSSTPINTRIEPYYSIYNSSPSQ 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tre1	NP_001284901.1	7tm_1	52..323	CDD:278431	78/342 (23%)
Gpr75	NP_780699.2	7tmA_GPR75	44..387	CDD:320136	83/368 (23%)
		TM helix 1	44..70	CDD:320136	7/26 (27%)
		TM helix 2	79..104	CDD:320136	7/24 (29%)
		TM helix 3	118..148	CDD:320136	9/29 (31%)
		TM helix 4	159..181	CDD:320136	11/43 (26%)
		TM helix 5	199..228	CDD:320136	11/29 (38%)
		TM helix 6	314..344	CDD:320136	11/29 (38%)
		TM helix 7	355..380	CDD:320136	5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..475		6/31 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24228
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100