DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tre1 and APLNR

DIOPT Version :9

Sequence 1:	NP_001284901.1	Gene:	Tre1 / 140439	FlyBaseID:	FBgn0046687	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_005152.1	Gene:	APLNR / 187	HGNCID:	339	Length:	380	Species:	Homo sapiens

Alignment Length:	338	Identity:	70/338 - (20%)
Similarity:	136/338 - (40%)	Gaps:	74/338 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 DEPAAATQSIYPHSATLFAAISACVFVTIGVLGNLITLLALLKSPTIREHATTAFVISLSISDLL 84
            |..:....:.:..|..|..||...||: :|..||.:.|..:.:|...:..:...|:.||:::||.
Human    14 DNQSECEYTDWKSSGALIPAIYMLVFL-LGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLT 77

  Fly    85 FCSFSLPLTAVRFFQE-SWTFGTTLCKIFPVIFYGNVAVSLLSMVGITLNRYILIACHSRYSQIY 148
            |. .:|||.|...::: .|.|||..||:...:.:.|:..|:..:.|::.:||:.|......:::.
Human    78 FV-VTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLR 141

  Fly   149 KPKFITLQLLFVWAVSFLLLLP-PILGIWGEMG--------LD---EATFSCTILKKEGRSIKKT 201
            ......:....:|.::.||.:| .:|...|::.        :|   .||.|.....:.|..:..|
Human   142 LRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSST 206

  Fly   202 LFVIGFLLPCLVIIVSYSCIYITVLHQKKKIRNHDNFQIAAAKGSSSSGGGSYMTTTCTRKARED 266
              .:||::|..:::..|..|..|:....:|.|                          ....|:.
Human   207 --TVGFVVPFTIMLTCYFFIAQTIAGHFRKER--------------------------IEGLRKR 243

  Fly   267 NRLTVMMVTIFLCFLVCFLPLMLANVVDDERNTSYPWLHIIASVMAW------------------ 313
            .||..::|.:.:.|.:|::|..|...           |:::.|::.|
Human   244 RRLLSIIVVLVVTFALCWMPYHLVKT-----------LYMLGSLLHWPCDFDLFLMNIFPYCTCI 297

  Fly   314 --ASSVINPIIYA 324
              .:|.:||.:||
Human   298 SYVNSCLNPFLYA 310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tre1	NP_001284901.1	7tm_1	52..323	CDD:278431	60/303 (20%)
APLNR	NP_005152.1	7tmA_Apelin_R	19..320	CDD:341340	69/333 (21%)
		TM helix 1	30..56	CDD:341340	9/26 (35%)
		TM helix 2	64..89	CDD:341340	10/25 (40%)
		TM helix 3	102..132	CDD:341340	7/29 (24%)
		TM helix 4	145..166	CDD:341340	4/20 (20%)
		TM helix 5	198..227	CDD:341340	7/30 (23%)
		TM helix 6	241..271	CDD:341340	8/40 (20%)
		TM helix 7	288..313	CDD:341340	5/23 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	342..380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24228
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010