Protein Alignment Tre1 and AGTR2

DIOPT Version :10

• Sequence 1: NP_001284901.1
• Gene: Tre1 / 140439
• FlyBaseID: FBgn0046687
• Length: 399
• Species: Drosophila melanogaster
• Sequence 2: NP_000677.2
• Gene: AGTR2 / 186
• HGNCID: 338
• Length: 363
• Species: Homo sapiens
• Alignment Length: 339
• Identity: 71/339 - (20%)
• Similarity: 134/339 - (39%)
• Gaps: 100/339 - (29%)

  Fly    44 VFVTIGVLGNL--ITLLALLKSPTIREHATTAFVISLSISDLLFCSFSLPLTAVRF-FQESWTFG 105
            :|| ||.|.|:  :||....|.|   :..::.::.:|:::|||..: :|||.|..: ::..|.||
Human    54 IFV-IGFLVNIVVVTLFCCQKGP---KKVSSIYIFNLAVADLLLLA-TLPLWATYYSYRYDWLFG 113

  Fly   106 TTLCKIFPVIFYGNVAVSLLSMVGITLNRYILIACHSRYSQIYKPKFITLQLLFVWAVSFLLLLP 170
            ..:||:|......|:..|:..:..::::||..: .:...||...|...:..:..||.::.|..||
Human   114 PVMCKVFGSFLTLNMFASIFFITCMSVDRYQSV-IYPFLSQRRNPWQASYIVPLVWCMACLSSLP 177

  Fly   171 PI----------LGI--------------WGEMGLDEATFSCTILKKEGRSIKKTLFVIGFLLPC 211
            ..          ||:              |                ..|.::.|.  ::||::|.
Human   178 TFYFRDVRTIEYLGVNACIMAFPPEKYAQW----------------SAGIALMKN--ILGFIIPL 224

  Fly   212 LVIIVSYSCIYITVLHQKKKIRNHDNFQIAAAKGSSSSGGGSYMTTTCTRKAREDNRLTVMMVTI 276
            :.|...|..|      :|..::.:                 ||.....||     :::..|...:
Human   225 IFIATCYFGI------RKHLLKTN-----------------SYGKNRITR-----DQVLKMAAAV 261

  Fly   277 FLCFLVCFLPLMLANVVDDERNTSYPWLHII---------------ASVMAWASSVINPIIYA-A 325
            .|.|::|:||..:...:|     :..|:.:|               |.::.:.:|.:||.:|. .
Human   262 VLAFIICWLPFHVLTFLD-----ALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFV 321

  Fly   326 SNRNYSESIFYFRV 339
            .||...:....|||
Human   322 GNRFQQKLRSVFRV 335

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tre1	NP_001284901.1	7tmA_GPR84-like	37..341	CDD:320338	71/339 (21%)
		TM helix 1	37..63	CDD:320338	8/20 (40%)
		TM helix 2	71..94	CDD:320338	7/22 (32%)
		TM helix 3	109..139	CDD:320338	7/29 (24%)
		TM helix 4	153..171	CDD:320338	4/17 (24%)
		TM helix 5	195..220	CDD:320338	7/24 (29%)
		TM helix 6	264..294	CDD:320338	6/29 (21%)
		TM helix 7	302..327	CDD:320338	7/40 (18%)
AGTR2	NP_000677.2	7tmA_AT2R	45..329	CDD:341341	68/331 (21%)
		TM helix 1	46..72	CDD:341341	8/18 (44%)
		TM helix 2	79..104	CDD:341341	8/25 (32%)
		TM helix 3	117..147	CDD:341341	7/30 (23%)
		TM helix 4	158..182	CDD:341341	5/23 (22%)
		TM helix 5	208..237	CDD:341341	8/36 (22%)
		TM helix 6	249..279	CDD:341341	8/34 (24%)
		TM helix 7	297..322	CDD:341341	5/24 (21%)
		Helix VIII. /evidence=ECO:0000269|PubMed:28379944	324..333		1/8 (13%)