Protein Alignment Tre1 and AGTR1

DIOPT Version :10

• Sequence 1: NP_001284901.1
• Gene: Tre1 / 140439
• FlyBaseID: FBgn0046687
• Length: 399
• Species: Drosophila melanogaster
• Sequence 2: NP_000676.1
• Gene: AGTR1 / 185
• HGNCID: 336
• Length: 359
• Species: Homo sapiens
• Alignment Length: 391
• Identity: 93/391 - (23%)
• Similarity: 165/391 - (42%)
• Gaps: 103/391 - (26%)

  Fly    17 MQMDEPAAATQS-IYPHSATLFAAISACVFVTIGVLGNLITLLAL---LKSPTIREHATTAFVIS 77
            :|.|.|.|...: |:....||::.|    || :|:.||.:.::.:   :|..|:    .:.|:::
Human    14 IQDDCPKAGRHNYIFVMIPTLYSII----FV-VGIFGNSLVVIVIYFYMKLKTV----ASVFLLN 69

  Fly    78 LSISDLLFCSFSLPLTAVRFFQE-SWTFGTTLCKIFPVIFYGNVAVSLLSMVGITLNRYILIACH 141
            |:::||.|. .:|||.||....| .|.||..||||.......|:..|:..:..::::||:.|. |
Human    70 LALADLCFL-LTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIV-H 132

  Fly   142 SRYSQIYKPKFIT-LQLLFVWAVSFLLLLPPILGIWGEMGLDEATFSCTILKKEGRSIKKTL--- 202
            ...|::.:...:. :..:.:|.::.|..||.|  |...:...|.| :.|:......|...||
Human   133 PMKSRLRRTMLVAKVTCIIIWLLAGLASLPAI--IHRNVFFIENT-NITVCAFHYESQNSTLPIG 194

  Fly   203 -----FVIGFLLPCLVIIVSYSCIYITVLH----QKKKIRNHDNFQIAAAKGSSSSGGGSYMTTT 258
                 .::|||.|.|:|:.||:.|:..:..    ||.|.||.|.|:|
Human   195 LGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKI------------------ 241

  Fly   259 CTRKAREDNRLTVMMVTIFLCF------LVCFLPLM----------LANVVDDERNTSYPWLHII 307
                        :|.:.:|..|      :..||.::          :|::||    |:.|    |
Human   242 ------------IMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVD----TAMP----I 286

  Fly   308 ASVMAWASSVINPIIYAASNRNYSESIFYFRVAYYKIFALLKFWGEPLSPMPSRNYHQSKNSKEL 372
            ...:|:.::.:||:.|....:.:..   ||       ..|||:       :|.:....|..|.::
Human   287 TICIAYFNNCLNPLFYGFLGKKFKR---YF-------LQLLKY-------IPPKAKSHSNLSTKM 334

  Fly   373 S 373
            |
Human   335 S 335

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tre1	NP_001284901.1	7tmA_GPR84-like	37..341	CDD:320338	79/336 (24%)
		TM helix 1	37..63	CDD:320338	6/28 (21%)
		TM helix 2	71..94	CDD:320338	8/22 (36%)
		TM helix 3	109..139	CDD:320338	7/29 (24%)
		TM helix 4	153..171	CDD:320338	3/18 (17%)
		TM helix 5	195..220	CDD:320338	11/32 (34%)
		TM helix 6	264..294	CDD:320338	6/45 (13%)
		TM helix 7	302..327	CDD:320338	6/24 (25%)
AGTR1	NP_000676.1	7tmA_AT1R	29..313	CDD:320320	79/338 (23%)
		TM helix 1	30..56	CDD:320320	8/30 (27%)
		TM helix 2	63..88	CDD:320320	10/25 (40%)
		TM helix 3	101..131	CDD:320320	7/29 (24%)
		TM helix 4	144..165	CDD:320320	5/22 (23%)
		TM helix 5	192..221	CDD:320320	9/28 (32%)
		TM helix 6	233..263	CDD:320320	9/59 (15%)
		TM helix 7	281..306	CDD:320320	8/32 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	335..359		1/1 (100%)