DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tre1 and npr-25

DIOPT Version :9

Sequence 1:	NP_001284901.1	Gene:	Tre1 / 140439	FlyBaseID:	FBgn0046687	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_505883.1	Gene:	npr-25 / 179570	WormBaseID:	WBGene00011381	Length:	376	Species:	Caenorhabditis elegans

Alignment Length:	326	Identity:	64/326 - (19%)
Similarity:	122/326 - (37%)	Gaps:	67/326 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 SAC-VFVTIG---VLGNLITLLALLKSPTIREHATTAFVISLSISDLLFCSFSLPLTAVRFFQES 101
            |.| ||.|:|   ||..:..:...|||.......|..::::|...||| .:.|:|.:.......:
Worm    28 SICFVFGTLGNTAVLSYVFFITRSLKSSVTALGNTFIYIVALCAVDLL-VTVSIPFSLSYMILNN 91

  Fly   102 WTFGTTLCKIFPVIFYGNVAVSLLSMVGITLNRYILIACHSRYSQIYKPKFITLQLLFVWAVSFL 166
            |.||..:|||..::...|...|...:..:..:||:.| ||....:|::.:. |:.:..:.|...|
Worm    92 WVFGELVCKIHFMLELSNKMCSTFILTALAFDRYMAI-CHPEIKRIHEMRH-TIYITTILATLSL 154

  Fly   167 LLLPPILGIWGEMGLDEATFSC----TILKKEGRSIKKTLFVIG-----------------FLLP 210
            .|:.|::     :.....:|..    ...|.|...:.:.:.:.|                 ||||
Worm   155 FLISPVV-----LSARVTSFKSGQYFVSAKNERHEVIRQMCIDGMALEWKVWVSAFLIFFAFLLP 214

  Fly   211 CLVIIVSYSCIYITVLHQKKKIRNHDNFQIAAAKGSSSSGGGSYMTTTCTRKAREDNRLTVMMVT 275
            |.::...|:.|.:.:..|::                           |..:......|:|:..:.
Worm   215 CTLLTYFYAKIVLRLRRQRR---------------------------TMLQSRIPLRRITIYTMA 252

  Fly   276 IFLCFLVCFLPLML-------ANVVDDERNTSYPWLHIIASVMAWASSVINPIIYAASNRNYSES 333
            ....:|.|.:|..|       :.|:..:.|.........:.::.:.|:..|.|.||..|..:.:.
Worm   253 ATFFYLSCHIPFWLPQIYNIFSTVLGHKMNPKVMTFTYYSHLLPFISAAFNWIFYARLNSQFKKG 317

  Fly   334 I 334
            :
Worm   318 L 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tre1	NP_001284901.1	7tm_1	52..323	CDD:278431	53/298 (18%)
npr-25	NP_505883.1	7tm_classA_rhodopsin-like	24..311	CDD:381740	63/317 (20%)
		TM helix 1	24..48	CDD:381740	8/19 (42%)
		TM helix 2	63..84	CDD:381740	6/21 (29%)
		TM helix 3	100..122	CDD:381740	4/21 (19%)
		TM helix 4	144..160	CDD:381740	3/15 (20%)
		TM helix 5	200..223	CDD:381740	5/22 (23%)
		TM helix 6	244..269	CDD:381740	6/24 (25%)
		TM helix 7	286..311	CDD:381740	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24228
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100