DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tre1 and Gpr50

DIOPT Version :9

Sequence 1:	NP_001284901.1	Gene:	Tre1 / 140439	FlyBaseID:	FBgn0046687	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_034470.1	Gene:	Gpr50 / 14765	MGIID:	1333877	Length:	591	Species:	Mus musculus

Alignment Length:	327	Identity:	87/327 - (26%)
Similarity:	152/327 - (46%)	Gaps:	43/327 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 YPHSATLFAAISACVFVTIGVLGNLITLLALLKSPTIREHATTAFVISLSISDLLFCSFSLPLTA 94
            ||.:..:|...:..:.|.:.::||.:.:||:.|:..:| ::...||.|||::|:|...:..||..
Mouse    31 YPPALIIFMFCAMVITVVVDLIGNSMVILAVTKNKKLR-NSGNIFVASLSVADMLVAIYPYPLML 94

  Fly    95 VRFFQESWTFGTTLCKIFPVIFYGNVAVSLLSMVGITLNRYILIACHS-RYSQIYKPKFITLQLL 158
            .......|......|::..::...:|..|:.::..|.:|||..| ||| :|.:|:..:...:.|:
Mouse    95 YAMSVGGWDLSQLQCQMVGLVTGLSVVGSIFNITAIAINRYCYI-CHSLQYKRIFSLRNTCIYLV 158

  Fly   159 FVWAVSFLLLLPPILGIWGEMGLDEATFSCTILKKEGRSIKKTLFVIGFLLPCLVIIVSYSCIYI 223
            ..|.::.|.:||.:  ..|.:..|..|::|........:...|:..|.|:||.:::...|:.|:|
Mouse   159 VTWVMTVLAVLPNM--YIGTIEYDPRTYTCIFNYVNNPAFTVTIVCIHFVLPLIIVGYCYTKIWI 221

  Fly   224 TVLHQKKKI-RNHDNFQIAAAKGSSSSGGGSYMTTTCTRKAREDNRLTVMMVTIFLCFLVCFLPL 287
            .||..:... :|.|| |.|..:                      |.||  |..|||.|.||:.|:
Mouse   222 KVLAARDPAGQNPDN-QFAEVR----------------------NFLT--MFVIFLLFAVCWCPV 261

  Fly   288 ----MLANVVDDERNTSYP-WLHIIASVMAWASSVINPIIYAASNRNYSESIFYFRVAYYKIFAL 347
                :|..|:..|.....| ||::.|..:|:.:|.:|.|||...|.:       ||..|:.||..
Mouse   262 NVLTVLVAVIPKEMAGKIPNWLYLAAYCIAYFNSCLNAIIYGILNES-------FRREYWTIFHA 319

  Fly   348 LK 349
            ::
Mouse   320 MR 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tre1	NP_001284901.1	7tm_1	52..323	CDD:278431	75/277 (27%)
Gpr50	NP_034470.1	7tm_4	44..>189	CDD:304433	39/148 (26%)
		7tm_1	53..302	CDD:278431	75/277 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..427
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	121	1.000	Domainoid score	I5667
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24228
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010