DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tre1 and Agtr1a

DIOPT Version :9

Sequence 1:	NP_001284901.1	Gene:	Tre1 / 140439	FlyBaseID:	FBgn0046687	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_796296.1	Gene:	Agtr1a / 11607	MGIID:	87964	Length:	359	Species:	Mus musculus

Alignment Length:	388	Identity:	90/388 - (23%)
Similarity:	166/388 - (42%)	Gaps:	102/388 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 MQMDEPAAATQS-IYPHSATLFAAISACVFVTIGVLGNLITLLAL---LKSPTIREHATTAFVIS 77
            :|.|.|.|...| |:....||::.|    || :|:.||.:.::.:   :|..|:    .:.|:::
Mouse    14 IQDDCPRAGRHSYIFVMIPTLYSII----FV-VGIFGNSLVVIVIYFYMKLKTV----ASVFLLN 69

  Fly    78 LSISDLLFCSFSLPLTAVRFFQE-SWTFGTTLCKIFPVIFYGNVAVSLLSMVGITLNRYILIACH 141
            |:::||.|. .:|||.||....| .|.||..||||.......|:..|:..:..::::||:.|. |
Mouse    70 LALADLCFL-LTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIV-H 132

  Fly   142 SRYSQIYKPKFIT-LQLLFVWAVSFLLLLPPIL--GIWGEMGLDEATFSCTILKKEGRS------ 197
            ...|::.:...:. :..:.:|.::.|..||.::  .::   .::....:......|.|:
Mouse   133 PMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIHRNVY---FIENTNITVCAFHYESRNSTLPIG 194

  Fly   198 IKKTLFVIGFLLPCLVIIVSYSCIYITVLH----QKKKIRNHDNFQIAAAKGSSSSGGGSYMTTT 258
            :..|..::|||.|.|:|:.||:.|:..:..    ||.|.||.|.|:|
Mouse   195 LGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFRI------------------ 241

  Fly   259 CTRKAREDNRLTVMMVTIFLCF------LVCFLPLM----------LANVVDDERNTSYPWLHII 307
                        :|.:.:|..|      :..||.::          :|::||    |:.|    |
Mouse   242 ------------IMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCKIADIVD----TAMP----I 286

  Fly   308 ASVMAWASSVINPIIYAASNRNYSESIFYFRVAYYKIFALLKFWGEPLSPMPSRNYHQSKNSK 370
            ...:|:.::.:||:.|....:.:.:   ||       ..|||:     .| |....|.|.::|
Mouse   287 TICIAYFNNCLNPLFYGFLGKKFKK---YF-------LQLLKY-----IP-PKAKSHSSLSTK 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tre1	NP_001284901.1	7tm_1	52..323	CDD:278431	67/303 (22%)
Agtr1a	NP_796296.1	7tmA_AT1R	29..313	CDD:320320	74/338 (22%)
		TM helix 1	30..56	CDD:320320	8/30 (27%)
		TM helix 2	63..88	CDD:320320	10/25 (40%)
		TM helix 3	101..131	CDD:320320	7/29 (24%)
		TM helix 4	144..165	CDD:320320	4/20 (20%)
		TM helix 5	192..221	CDD:320320	10/28 (36%)
		TM helix 6	233..263	CDD:320320	9/59 (15%)
		TM helix 7	281..306	CDD:320320	8/32 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..359
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24228
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100