DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tre1 and mtnr1c

DIOPT Version :9

Sequence 1:	NP_001284901.1	Gene:	Tre1 / 140439	FlyBaseID:	FBgn0046687	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	XP_031747846.1	Gene:	mtnr1c / 100485432	XenbaseID:	XB-GENE-985295	Length:	429	Species:	Xenopus tropicalis

Alignment Length:	344	Identity:	94/344 - (27%)
Similarity:	159/344 - (46%)	Gaps:	58/344 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 QMDEPAAATQSIYPHSATLFAAISACVFVTIGVLGNLITLLALLKSPTIREHATTAFVISLSISD 82
            :.|....|:|.:     |...|:.....:.:.||||::.:|::|::..: ::|...||:|||::|
Frog    20 EQDAQDGASQGL-----TSALAVVLIFTIIVDVLGNMLVILSVLRNKKL-QNAGNLFVVSLSVAD 78

  Fly    83 LLFCSFSLPLTAVRFFQESWTFGTTLCKIFPVIFYGNVAVSLLSMVGITLNRYILIACHS-RYSQ 146
            |:...:..|:..:..||..||.|...|:|...:...:|..|:.::..|.:|||..| ||| ||.:
Frog    79 LVVAVYPYPVILIAIFQNGWTLGNIHCQISGFLMGLSVIGSVFNITAIAINRYCYI-CHSLRYDK 142

  Fly   147 IYKPKFITLQLLFVWAVSFLLLLPPILGIWGEMGLDEATFSCTILKKEGRSIKKTLFVIGFLLPC 211
            ::..|.....|...|.::.:.::|..  ..|.:..|...||||..:....|...|:.|:.|::|.
Frog   143 LFNQKSTWCYLGLTWILTIIAIVPNF--FVGSLQYDPRIFSCTFAQTVSSSYTITVVVVHFIVPL 205

  Fly   212 LVIIVSYSCIYITVLHQKKKIRNHDNFQIAAAKGSSSSGGGSYMTTTCTRKAREDNRLTVMMVTI 276
            .|:...|..|::.|:..|.::| ||..|              .:|.|..|     |.||  |..:
Frog   206 SVVTFCYLRIWVLVIQVKHRVR-HDFKQ--------------KLTPTDLR-----NFLT--MFVV 248

  Fly   277 FLCFLVCFLPLM---LANVVDDERNTSYP---------WLHIIASVMAWASSVINPIIYAASNRN 329
            |:.|.||:.||.   ||..::       |         ||.:::..||:.:|.:|.:||...|:|
Frog   249 FVLFAVCWAPLNFIGLAVAIN-------PLHVAPKIPEWLFVVSYFMAYFNSCLNAVIYGLLNQN 306

  Fly   330 YSESIFYFRVAYYKIFALL 348
                   ||..|.:|...|
Frog   307 -------FRKEYKRILMSL 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tre1	NP_001284901.1	7tm_1	52..323	CDD:278431	78/283 (28%)
mtnr1c	XP_031747846.1	7tm_GPCRs	33..311	CDD:421689	87/317 (27%)
		TM helix 1	34..60	CDD:410628	7/25 (28%)
		TM helix 2	67..92	CDD:410628	8/24 (33%)
		TM helix 3	105..135	CDD:410628	9/30 (30%)
		TM helix 4	147..169	CDD:410628	4/23 (17%)
		TM helix 5	189..218	CDD:410628	8/28 (29%)
		TM helix 6	236..266	CDD:410628	13/36 (36%)
		TM helix 7	279..304	CDD:410628	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	121	1.000	Domainoid score	I5619
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D321514at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48790
Panther	1	1.100	-	-	O	PTHR24228
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020