DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tre1 and si:cabz01093077.1

DIOPT Version :9

Sequence 1:	NP_001284901.1	Gene:	Tre1 / 140439	FlyBaseID:	FBgn0046687	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	XP_005173521.2	Gene:	si:cabz01093077.1 / 100329837	ZFINID:	ZDB-GENE-160113-45	Length:	352	Species:	Danio rerio

Alignment Length:	405	Identity:	99/405 - (24%)
Similarity:	171/405 - (42%)	Gaps:	102/405 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 TGYFQDADMQMDEPAAATQSIYPHSATLFAAISACVFVTIGVLGNLITLLALLKSPTIREHATTA 73
            |.|:.:..|...|..    |:.||   :.|||...||| :|::||:|.|..||||..:: :.|..
Zfish    13 TDYYYEVTMCNTEEG----SLNPH---IKAAIFYIVFV-LGLVGNIIVLWVLLKSMHVK-NMTNL 68

  Fly    74 FVISLSISDLLFCSFSLPLTAVRFFQESWTFGTTLCK----IFPVIFYGNV-AVSLLSMVGITLN 133
            .:::|::||||.. .|||..|: :.|..:.....:||    .:.|.||..: .|:|:|     ::
Zfish    69 CLLNLAMSDLLMV-LSLPFWAL-YAQGHYLKTDAMCKAMAGAYQVGFYSGIFFVTLMS-----VD 126

  Fly   134 RYILIACHS---------RYSQIYKPKFITLQLLFVWAVSFLLLLPPILGIWGEMGLDEATFSCT 189
            ||::|. |:         ||..:..        :.:|.||....||.:  |:.|:..|..:.||.
Zfish   127 RYLVIV-HAVAVLGAKMLRYGIVAS--------VIIWMVSIGAALPEV--IFAEVVKDSESNSCQ 180

  Fly   190 ILKKEGRSIKKTLF------VIGFL--LPCLVIIVSYSCIYITVLHQKKKIRNHDNFQIAAAKGS 246
            ....:..:.|..||      .:|..  ||    |::| | |:.||...||.:|
Zfish   181 RHYPDESARKWKLFRNFGENAVGLFISLP----IIAY-C-YLRVLMVVKKTKN------------ 227

  Fly   247 SSSGGGSYMTTTCTRKAREDNRLTVMMVTIFLCFLVCFLP----LMLANVVDDERNTS---YPWL 304
                             .:.||...:::.|.:.|:|.::|    :.|..:.:.:..||   |..:
Zfish   228 -----------------SKKNRAIKLILGIVIMFVVFWVPYNVVVFLKTLHEFDMLTSCEPYKII 275

  Fly   305 HI---IASVMAWASSVINPIIYAASNRNYSESIFYFRVAYYKIFALLKFWGEPLSPMPSRNYHQS 366
            ::   :...:|.....:||.|||.....:.:   |...|:.|....||.:..  :|..||   .|
Zfish   276 NMAMDVTETIALTHCCVNPFIYAFVGEKFRK---YLASAFSKYLRCLKTYQS--TPSQSR---IS 332

  Fly   367 KNSKELSGVIRSTPL 381
            :|....:.:..::|:
Zfish   333 ENDTSNTAIFSTSPM 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tre1	NP_001284901.1	7tm_1	52..323	CDD:278431	71/302 (24%)
si:cabz01093077.1	XP_005173521.2	TM helix 5	192..221	CDD:320115	11/34 (32%)
		TM helix 6	228..258	CDD:320115	6/29 (21%)
		TM helix 7	276..301	CDD:320115	6/24 (25%)
		7tmA_Chemokine_R	37..308	CDD:320115	79/328 (24%)
		TM helix 1	37..59	CDD:320115	11/22 (50%)
		TM helix 2	66..91	CDD:320115	10/26 (38%)
		TM helix 3	102..132	CDD:320115	10/34 (29%)
		TM helix 4	146..166	CDD:320115	5/29 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24228
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100