DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tre1 and gpr84

DIOPT Version :9

Sequence 1:	NP_001284901.1	Gene:	Tre1 / 140439	FlyBaseID:	FBgn0046687	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	XP_021332416.1	Gene:	gpr84 / 100126017	ZFINID:	ZDB-GENE-070928-33	Length:	410	Species:	Danio rerio

Alignment Length:	392	Identity:	93/392 - (23%)
Similarity:	170/392 - (43%)	Gaps:	85/392 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 FQDAD-MQMDEPAAATQSIYPHSATLFAAISACVFVTIGVLGNLITLLALLKSPTIREHATTAF- 74
            :.|.| ::.|..:.|:.|:  .....|..:.......:|.:||::|:||.:....:|    |.|
Zfish    10 WNDTDLLRNDSFSCASPSV--EGYRYFGVLLGSAVTIVGTIGNILTVLAFVTDANLR----TRFN 68

  Fly    75 --VISLSISDLLFCSFSLPLTAVRFFQESWTFGTTLCKIFPVIFYGNVAVSLLSMVGITLNRYIL 137
              :::|:.:|||:|:...|::...:....|..|.|.|::|.::.:.:.:||::::..|.::||::
Zfish    69 VLIVNLAFADLLYCTILQPVSVDSYLHLHWRGGATWCRMFGLLLFLSNSVSIITLCLIAMSRYLV 133

  Fly   138 IACHSRYSQIYKPKFITLQLLFVWAVSFLLLLPPILG------IWGEMGLDEATFSCTILKKEGR 196
            :|        ::.......||....|:.||:...:||      :|..........:|:..:.:||
Zfish   134 VA--------HRTSSCARLLLSQRGVAALLISSWVLGLASFAPLWPVYVFAPQVCTCSFHRTKGR 190

  Fly   197 SIKKTLFVIGFLLPCLVIIVSYSCIYITVLHQKKKI------RNHDNFQIAAAKGSSSSGG---G 252
            .....|..:.|.|....:.:.|..||..|....|..      |.....:.|.|:|::...|   |
Zfish   191 PYTTVLLFLYFFLGLGFVGLFYFLIYRKVSVAAKAFLKYRPSRRSSKRKQAEAEGTTDDSGISAG 255

  Fly   253 SYMTTTC----------------------------------TRKAR--------------EDN-- 267
            :..|.:|                                  |.||.              |||
Zfish   256 ASTTQSCEISSDGAVAEQHGKQAQEGQTTTQNATQHASSETTSKASPVVIQNTPAAANSGEDNEF 320

  Fly   268 -RLTVMMVTIFLCFLVCFLPLMLANVVDDERNTSYPWLHIIASVMAWASSVINPIIYAASNRNYS 331
             |:|.|..|:||||:.||.|.:|.||. |::|.:...:|:|.:.:.|.:|.|||::|||.||.::
Zfish   321 KRVTRMCFTVFLCFVGCFAPFLLLNVA-DKKNRAPQVIHMICANLTWLNSCINPLLYAAMNRQFN 384

  Fly   332 ES 333
            ::
Zfish   385 QA 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tre1	NP_001284901.1	7tm_1	52..323	CDD:278431	81/339 (24%)
gpr84	XP_021332416.1	7tmA_GPR84-like	33..387	CDD:320338	88/367 (24%)
		TM helix 1	34..60	CDD:320338	7/25 (28%)
		TM helix 2	67..90	CDD:320338	7/22 (32%)
		TM helix 3	105..135	CDD:320338	7/29 (24%)
		TM helix 4	151..169	CDD:320338	5/17 (29%)
		TM helix 5	189..214	CDD:320338	6/24 (25%)
		TM helix 6	318..348	CDD:320338	15/30 (50%)
		TM helix 7	355..380	CDD:320338	10/24 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H41370
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45279
OrthoDB	1	1.010	-	-		D321514at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25938
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4597
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.960