Protein Alignment gucy2f and Gyc76C

DIOPT Version :9

• Sequence 1: NP_571939.2
• Gene: gucy2f / 140424
• ZFINID: ZDB-GENE-011128-7
• Length: 1107
• Species: Danio rerio
• Sequence 2: NP_001163473.1
• Gene: Gyc76C / 8674026
• FlyBaseID: FBgn0266136
• Length: 1525
• Species: Drosophila melanogaster
• Alignment Length: 1117
• Identity: 365/1117 - (32%)
• Similarity: 559/1117 - (50%)
• Gaps: 185/1117 - (16%)

Zfish    80 ASRLAVGRINNDFSLDLGCTMDFVILQEACET---SKALTSFVQYENVADAFVGPTNPGYCNAAA 141
            |..:|:..:|.|.:|.....:|........:|   :||:|..: .:.:|..| ||..|  |...|
  Fly    49 ALTMALDEVNKDPNLLPNVYLDLRWNDTKGDTVLATKAITEMI-CDGIATIF-GPEGP--CYVEA 109

Zfish   142 LMSKNWDKSLFSWACVNHELDRVQGYPTFARTLPSPLRV---LFNVLKFFRWANIGIVSSNEDIW 203
            ::|::.:..:.|:.|..:   |....||||||.|...:|   |..:|:::.|....|:  .||:|
  Fly   110 IVSQSRNIPMISYKCAEY---RASAIPTFARTEPPDTQVVKSLLALLRYYAWNKFSIL--YEDVW 169

Zfish   204 IDTAAKLASALRNRGLPVGIVTSMGNNDT-----------------MLENTLMSIKNAGDIKVII 251
            ...|..|......|.:.:....|..:|..                 :::||:    |...|.|.:
  Fly   170 SPVADLLKDQATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTM----NRTRIYVFL 230

Zfish   252 MCMHSVLIGGEQQATFLTKAYDMGL-ASGRYVFIPYDTLLYS----LPYI----NITY----YPL 303
            ...:|::       .|::.....|| |.|.|:.|..|.::||    ..|:    .||:    :..
  Fly   231 GAANSLV-------DFMSSMETAGLFARGEYMVIFVDMMVYSEREAEKYLRRVDQITFMSNCHST 288

Zfish   304 QNNSKLSKAYDAVLTITLDSDIMTFNE---------AFNAAKQLGELMVTQEPEQVSPLFGT-IY 358
            :|.::::::...|.:.....|.:.|.:         .||.  ::..|.|.....:...::.. :|
  Fly   289 ENFNQMARSLLVVASTPPTKDYIQFTKQVQKYSSKPPFNL--EIPRLFVESNFSKFISIYAAYLY 351

Zfish   359 NSLYLLAKSMHN-ARRAGRWL----------SGTN-LAYFTRNITF---TGFNQDIQTDEQGNGQ 408
            :|:.|.|.::.. .|...|.|          :||. :....:|.|:   ||  ..|:.|:.|:.:
  Fly   352 DSVKLYAWAVDKMLREETRVLTDDVIFEVASNGTRVIDTIIKNRTYMSITG--SKIKIDQYGDSE 414

Zfish   409 TNYVIL--DTEAWGTQLYRCFLVDMTSDLVLFAGRFIHFPGESP-----------------PPSD 454
            .|:.:|  ....|...      .:|..:..:....:.|...|.|                 |..:
  Fly   415 GNFSVLAYKPHKWNNS------NNMPCNYHMVPVAYFHQGEEHPEYKLINGSIDWPSGGEKPADE 473

Zfish   455 SRCWFEDNAICTGGVDIIYVIIAFVIVLIIVL---GSIGLSLFIRRRIQQIQLIKGPNRILLTLE 516
            ..|.|. |.:|... |..|......:||.::|   |.|.:|::.:.:|:            |.:|
  Fly   474 PMCGFA-NELCKKD-DTHYTSTVAAVVLGVLLFCSGVITMSIYRKWKIE------------LEIE 524

Zfish   517 DLTF-INPQLSKRKITLEDLSD-SK-SYIEEKSTGDRSRSVNSMATATHETSNVAVYEGDWVWLK 578
            .|.: |:|...|.....|.:|. || |.:..:|.|  ||..|...|:|..      ..|..|.:|
  Fly   525 GLLWKIDPNEIKGYSGNEIVSSPSKVSLMSAQSYG--SRWTNQFVTSTGR------LRGAVVRIK 581

Zfish   579 KFTEGHFKEVKQSTTKIFTKMKDLRNENVNPFLGFFTDCEMFAIVTEHCSRGSLHDLLRNDDVKL 643
            :......:::.:...|....:::||::|:|.|:|...:.....:||::|::|||:|::.|:|:||
  Fly   582 ELKFPRKRDISREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKL 646

Zfish   644 DWMFKSSLVLDLIKGMKYLHHREFP-HGRLKSRNCVVDGRFVLKITDYGYNEILETQKAPKETLP 707
            |.:|.:||:.||||||.|:|:.:.. ||.|||.||||..|::|::||:|.:|:  .|.|..|::.
  Fly   647 DDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHEL--RQCAENESIG 709

Zfish   708 PEDLF----WTAPEHLRDPESPRKGTYKGDVYSFAIILQEVVVRGAPYCMLGLSPEEIIRKVKKP 768
            ....:    |.|||.||   :...|:.|||||:||||:.|:..|..|:..:...|:||:..|||.
  Fly   710 EHQHYRNQLWRAPELLR---NHIHGSQKGDVYAFAIIMYEIFSRKGPFGQINFEPKEIVDYVKKL 771

Zfish   769 P-----PMCRPTV--------APDQAPLECIQLMKQCWSEQPDRRPPFDQIFDQFKLINKGKKTN 820
            |     |. ||.|        .||.. |.||   :.||:|.|:.||.|..|.::.|.:..||..|
  Fly   772 PLKGEDPF-RPEVESIIEAESCPDYV-LACI---RDCWAEDPEERPEFSVIRNRLKKMRGGKTKN 831

Zfish   821 IIDSMLRMLEQYSSNLEDLIRERTEELEVEKQRTEKLLSEMLPPSVAEALKTGASVEPEYFDQVT 885
            |:|.|:.|:|:|::||||::.|||..|..||.:||.||..|||.||||.|..|..|||..:|.||
  Fly   832 IMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVT 896

Zfish   886 IYFSDIVGFTTISSLSDPIEVVDLLNDLYSLFDAVLGSHDVYKVETIGDAYMVASGLPKKNGNKH 950
            ||||||||||.:|:.|.|::||:.|||||::||.::..:||||||||||||||.||||.|||::|
  Fly   897 IYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRH 961

Zfish   951 AAEIANMSLNILSSVGSFKMRHMPEVPVRIRIGIHSGPCVAGVVGLTMPRYCLFGDTVNTASRME 1015
            |.|||:|:|.:|.:|...::.|.|...:::|||:|:||.||||||||||||||||||||||||||
  Fly   962 AGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRME 1026

Zfish  1016 STGLPYRIHVNISTVQILRSLNDGYKIDVRGKTELKGKGIEETYWLVGKAN-------------- 1066
            |.|...:||::......|..|..||..:.||...:||||...|:||.| ||
  Fly  1027 SNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTG-ANENAIQKKLVDMMDM 1090

Zfish  1067 ----FTKPLPNP 1074
                |::|..:|
  Fly  1091 PPPLFSRPRKSP 1102

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gucy2f	NP_571939.2	PBP1_sensory_GC_DEF_like	59..440	CDD:107366	88/422 (21%)
		PK_GC-2D	551..816	CDD:270945	100/282 (35%)
		HNOBA	<825..870	CDD:311573	25/44 (57%)
		CYCc	850..1042	CDD:214485	115/191 (60%)
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	88/425 (21%)
		ANF_receptor	48..412	CDD:279440	83/386 (22%)
		PK_GC-A_B	543..827	CDD:270944	106/301 (35%)
		HNOBA	<835..881	CDD:285003	25/45 (56%)
		CYCc	860..1052	CDD:214485	114/191 (60%)
		Guanylate_cyc	887..1074	CDD:278633	109/186 (59%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810