DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bcl11a and CG4360

DIOPT Version :9

Sequence 1:	NP_001229863.1	Gene:	Bcl11a / 14025	MGIID:	106190	Length:	835	Species:	Mus musculus
Sequence 2:	NP_650879.1	Gene:	CG4360 / 42413	FlyBaseID:	FBgn0038787	Length:	556	Species:	Drosophila melanogaster

Alignment Length:	557	Identity:	119/557 - (21%)
Similarity:	191/557 - (34%)	Gaps:	164/557 - (29%)

- Green bases have known domain annotations that are detailed below.

Mouse   340 QRLLQPFQP-------------------GSKPPFLATPPLPPLQSAPPPSQ----PPVKSKSCEF 381
            |.:|.|..|                   ||..|.  :|....:||.....:    .|.|.|.|..
  Fly    84 QAMLHPQHPLVHLLDISTTTANSGGGGGGSHTPI--SPMKQEVQSVISEEEVVVDDPRKKKQCHV 146

Mouse   382 CGKTFKFQSNLVVHRRSHTGEKPYKCNLCDHACTQASKLKRHMKTHMHKSSPMTVKSDDGLSTAS 446
            |...|:..:.|..|.:.||.|:||||..||.|..|.|.|..|:|.|                  :
  Fly   147 CKNKFRQLTTLRNHMKIHTDERPYKCKHCDKAFRQISTLTNHVKIH------------------T 193

Mouse   447 SPEPGTSDLVGSASSALKSVVAKFKS-----ENDP----NLIPENGDEEEEEDDEEEEEEEEEEE 502
            ..:|.|.::.........:::...|:     .:.|    |..|:.|..:..:....:..:::.:.
  Fly   194 GEKPFTCNICAKDFRQQSTLINHIKTHKAAESSTPTSLLNYQPQTGSGKHRKSQMHQAYQQQHQR 258

Mouse   503 EELTESERVDYGFGLSLEAARHHENSSRGAVVGVGDEGRALPDVMQGMVLSSMQHFSEAFHQVLG 567
            .:::::.   |....|..||.......:.:|.     .|..|.      ||::.:
  Fly   259 VQISKTL---YSGSYSSPAAEELVKPFQCSVC-----KRRFPQ------LSTLHN---------- 299

Mouse   568 EKHKRSHLAEAEGHRDTCDE-------------------------------------DSVAGESD 595
              |:|:|:.......:|||:                                     :.:...:.
  Fly   300 --HERTHIDPKPYKCETCDKSFSQLATLANHKKIHTGDKPYTCSYCHMQFRQQSTLTNHLKTHTH 362

Mouse   596 RIDDGTVNGRGCSPGESASGGLSKKLLLGSPSSLSPFSKRIKLEKEFDLPPAAMPNTENVYSQWL 660
            :|..|.|.|.|     ...|.::..:....|:.|:|.:::        |....:||.       |
  Fly   363 QIAPGGVGGAG-----GGGGAVTATVDHSMPAPLAPGTQQ--------LTSGLLPNN-------L 407

Mouse   661 AGYAASRQLKD--PFLTFGDSRQSPFASSSEHSSENGSLRFSTPPGELDGGISGRSGTGSG---- 719
            .|..|:....|  |.|.|.|       .|:..||...:...:|.......|     |:.||
  Fly   408 HGSTANIIQLDHHPLLHFLD-------GSTTVSSVVATAAANTKVEHFQAG-----GSPSGRMTV 460

Mouse   720 -GSTPHISGPGPGRPSSKEGRRSDTCEYCGKVFKNCSNLTVHRRSHTGERPYKCELCNYACAQSS 783
             |:...:.|..|.||..        |..|.:.|...|.|..|.::||||:||||::|.....|.:
  Fly   461 VGTINMLKGDNPDRPFG--------CSVCQRFFSQQSTLVNHIKTHTGEKPYKCKICEVNFRQVA 517

Mouse   784 KLTRHMKTHGQVGKDVYKCEICKMPFSVYSTLEKHMK 820
            .|..|||.|  .|:..|.|..|...|...|||:.|::
  Fly   518 TLNNHMKIH--TGEKPYNCSFCPKQFRQKSTLQNHLR 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bcl11a	NP_001229863.1	Required for nuclear body formation and for SUMO1 recruitment	1..210
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	323..376		11/58 (19%)
		zf-C2H2	378..399	CDD:395048	5/20 (25%)
		C2H2 Zn finger	379..399	CDD:275368	5/19 (26%)
		zf-H2C2_2	391..416	CDD:404364	12/24 (50%)
		C2H2 Zn finger	407..427	CDD:275368	9/19 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	421..458		5/36 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	471..512		5/49 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	572..619		11/83 (13%)
		zf-C2H2	743..764	CDD:395048	6/20 (30%)
		C2H2 Zn finger	744..764	CDD:275368	6/19 (32%)
		zf-H2C2_2	756..781	CDD:404364	11/24 (46%)
		C2H2 Zn finger	772..792	CDD:275368	7/19 (37%)
		C2H2 Zn finger	802..820	CDD:275368	7/17 (41%)
CG4360	NP_650879.1	C2H2 Zn finger	144..164	CDD:275368	5/19 (26%)
		zf-H2C2_2	157..181	CDD:290200	12/23 (52%)
		C2H2 Zn finger	172..192	CDD:275368	9/19 (47%)
		zf-H2C2_2	185..209	CDD:290200	6/41 (15%)
		C2H2 Zn finger	200..220	CDD:275368	1/19 (5%)
		C2H2 Zn finger	284..304	CDD:275368	7/42 (17%)
		zf-C2H2_8	287..363	CDD:292531	10/98 (10%)
		C2H2 Zn finger	312..332	CDD:275368	3/19 (16%)
		C2H2 Zn finger	340..360	CDD:275368	0/19 (0%)
		C2H2 Zn finger	478..498	CDD:275368	6/19 (32%)
		zf-H2C2_2	491..515	CDD:290200	11/23 (48%)
		C2H2 Zn finger	506..526	CDD:275368	7/19 (37%)
		zf-H2C2_2	519..543	CDD:290200	10/25 (40%)
		C2H2 Zn finger	534..554	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000