DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ADORA3 and adora1b

DIOPT Version :9

Sequence 1:	NP_000668.1	Gene:	ADORA3 / 140	HGNCID:	268	Length:	318	Species:	Homo sapiens
Sequence 2:	NP_001122056.1	Gene:	adora1b / 100150997	ZFINID:	ZDB-GENE-081105-156	Length:	341	Species:	Danio rerio

Alignment Length:	325	Identity:	159/325 - (48%)
Similarity:	223/325 - (68%)	Gaps:	16/325 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     1 MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLV 65
            ||.:   ||.|...|:.||:.|.:.:::|||:|:..||:|.||:.|||.|||||||||||||.||
Zfish     1 MPED---LSAAKALYMGMEVVIAVSSVIGNVMVVWAVKINKSLRDTTFCFIVSLALADIAVGALV 62

Human    66 MPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLA 130
            :||||.:|:|:..||||||.:.|.:|:.|.:||::|||||:|||||||:...||||.|.:|..:|
Zfish    63 IPLAITISIGLQTHFYSCLLVACTVLVLTQSSILALLAIAIDRYLRVKIPTSYKRVVTPKRAGIA 127

Human   131 LGLCWLVSFLVGLTPMFGWNMKLTSEYHRNV---TFLSCQFVSVMRMDYMVYFSFLTWIFIPLVV 192
            :.:||:|:|:||||||.|||...:.:.:.::   ..::|||.:|:.|:|||||:|..|:..||:.
Zfish   128 VFMCWMVAFIVGLTPMLGWNNLHSLQQNDSIGPDLIVTCQFENVISMEYMVYFNFFGWVLPPLLF 192

Human   193 MCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYF-- 255
            |..||.:|||:|..:|:..:|:..|...:|.:|.|.||||.|||||||:|||||.|:|||..|
Zfish   193 MLVIYSEIFYMIHKQLNKKVSSHSEPNKYYDKELKLAKSLALVLFLFAISWLPLHIMNCITLFFP 257

Human   256 NGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVC--------HPSDSLDTS 312
            ..|.|..::|:.|||:|.||.:||||||::||||:..:..|.|....|        .||:.||.:
Zfish   258 TCEKPMFLIYIAILLTHGNSAVNPIVYAFRIKKFRTAFYRIWKQYFCCKEAPPPDSQPSERLDNN 322

Human 313 312
Zfish 323 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADORA3	NP_000668.1	7tm_GPCRs	13..293	CDD:333717	147/284 (52%)
		TM helix 1	15..39	CDD:320095	9/23 (39%)
		TM helix 2	48..70	CDD:320095	18/21 (86%)
		TM helix 3	84..106	CDD:320095	10/21 (48%)
		TM helix 4	129..145	CDD:320095	8/15 (53%)
		TM helix 5	175..198	CDD:320095	11/22 (50%)
		TM helix 6	226..251	CDD:320095	18/24 (75%)
		TM helix 7	261..286	CDD:320095	13/24 (54%)
adora1b	NP_001122056.1	7tm_4	20..299	CDD:304433	143/278 (51%)
adora1b	NP_001122056.1	7tm_1	26..284	CDD:278431	136/257 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48050
OrthoDB	1	1.010	-	-		D252862at33208
OrthoFinder	1	1.000	-	-		FOG0000536
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24246
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.030