DRSC/TRiP Functional Genomics Resources

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Protein Alignment CRKL and Shark

DIOPT Version :10

Sequence 1:NP_005198.1 Gene:CRKL / 1399 HGNCID:2363 Length:303 Species:Homo sapiens
Sequence 2:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster


Alignment Length:272 Identity:70/272 - (25%)
Similarity:110/272 - (40%) Gaps:66/272 - (24%)


- Green bases have known domain annotations that are detailed below.


Human     9 SDRSAWYMGPVSRQEAQTRL-QGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRFK 72
            ||...||.|.:||:.|...| ||...|.||||:|||..||:|||:.....|.||.:     ||..
  Fly     5 SDPMKWYHGNLSREAADELLKQGYEDGTFLVRESSTAAGDFVLSLLCQGEVCHYQV-----RRHG 64

Human    73 IGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGN 137
             |:..|..:...::...:|.||  ||::...:         :|..|||...    |..:.|.|.:
  Fly    65 -GEDAFFSIDDKVQTKILHGLD--TLVDYYQQ---------AANGLPTKLT----VPLIRDLPPH 113

Human   138 DAED--------LPFKKGEILVIIE--KPEEQWWSARNKDGRVG--MIPVPYVEKLVRSSPHGKH 190
            :...        ....|.|..|:.|  |...:.:.|:|:||:..  :..:...|.:::...:.|.
  Fly   114 NTRSHGVTNLLHRATSKNESKVVFELLKCGYRNFDAKNQDGQTALHLAALHSDEDILKHLLNAKV 178

Human   191 GNRNSNSYGIPEPAH--AYAQPQT--TTPLPAVSGSPG--------------------------- 224
            ...:|:|:|. :|.|  |.::|.:  .|.:.|.:...|                           
  Fly   179 QVNSSDSFGC-QPLHYAARSKPASFIRTLISAQANVQGRNIDNGYVPLHEAAKHGNLEAVQELLL 242

Human   225 AAITPLPSTQNG 236
            |...|||.|.:|
  Fly   243 AEAPPLPRTSSG 254

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CRKLNP_005198.1 SH2_CRK_like 6..106 CDD:198180 36/97 (37%)
SH3_CRK_N 126..180 CDD:212692 12/65 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 184..234 15/80 (19%)
SH3_CRK_C 237..293 CDD:212693 70/272 (26%)
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210 34/90 (38%)
ANKYR <94..317 CDD:440430 34/166 (20%)
ANK repeat 124..151 CDD:293786 6/26 (23%)
ANK repeat 153..184 CDD:293786 4/30 (13%)
ANK repeat 186..217 CDD:293786 8/31 (26%)
ANK repeat 220..245 CDD:293786 1/24 (4%)
SH2_Cterm_shark_like 287..395 CDD:198211
PTKc_Syk_like 666..926 CDD:270650
Blue background indicates that the domain is not in the aligned region.

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