DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RBMXL3 and hnrnpdl

DIOPT Version :9

Sequence 1:	NP_001138818.1	Gene:	RBMXL3 / 139804	HGNCID:	26859	Length:	1067	Species:	Homo sapiens
Sequence 2:	NP_001011015.1	Gene:	hnrnpdl / 496424	XenbaseID:	XB-GENE-495016	Length:	297	Species:	Xenopus tropicalis

Alignment Length:	288	Identity:	69/288 - (23%)
Similarity:	97/288 - (33%)	Gaps:	111/288 - (38%)

- Green bases have known domain annotations that are detailed below.

Human     7 PEKLFIGGLNLKTDEKALKAEFGKYGHIIKVFLMKDRKTNKSRGFAFVTFESPADAKAAARDMNG 71
            |:|:|:|||:.:|.|:.:|..||.:|.|..:.|..|.|||:.|||.|||:......|........
Frog   110 PKKVFVGGLSPETTEEQIKQYFGGFGEIENIELPMDTKTNERRGFCFVTYTGEEPVKKLLESRFH 174

Human    72 KYLDGKA-IMVAQTIKPAFKSSRWVPPTPGSGSRSRFSHRTRGG-GSSPQRPPSQGRPDDGR--- 131
            :...||. |.|||               |....|.:...:.:|| |::..|..::||   ||
Frog   175 QIGTGKCEIKVAQ---------------PKEVYRQQQQKQQKGGRGAATGRGGARGR---GRGQG 221

Human   132 ---GYAGYFDLWPYRAPMPRKRGPPPRHWASPPHKRATPSSLAHSVGCGMRGKAPTVSGQDGYSG 193
               ||:.|:|                          ....|..::.....:|...:.||.| |||
Frog   222 WNQGYSNYYD--------------------------QNYGSYGNNGSYADQGYNNSYSGYD-YSG 259

Human   194 LQPRRWAGPPHKRAVPRSSLARIGGSGMPGKAPAVWGQDGYSGPRVREPLPPCRDPGDFVPALRD 258
            ..                                 :|..||:                  ....|
Frog   260 YN---------------------------------YGSYGYN------------------QGYTD 273

Human   259 YSRRYYGHSSVPDYRPLRGDGN-QNGYR 285
            ||    |..|.  |...||.|| ||.|:
Frog   274 YS----GQQST--YGKARGGGNHQNNYQ 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RBMXL3	NP_001138818.1	RRM	<1..>81	CDD:223796	28/74 (38%)
		RRM_RBMX_like	7..86	CDD:240828	31/79 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..131		8/41 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..175		1/30 (3%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..305		9/20 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	357..1067
hnrnpdl	NP_001011015.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		RRM1_hnRPDL	27..102	CDD:410152
		RRM2_hnRPDL	112..186	CDD:409998	27/73 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	192..224		9/34 (26%)
		Trnau1ap	222..>278	CDD:407550	19/137 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910