DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RBMXL3 and CG3335

DIOPT Version :9

Sequence 1:	NP_001138818.1	Gene:	RBMXL3 / 139804	HGNCID:	26859	Length:	1067	Species:	Homo sapiens
Sequence 2:	NP_648337.1	Gene:	CG3335 / 39119	FlyBaseID:	FBgn0036018	Length:	918	Species:	Drosophila melanogaster

Alignment Length:	239	Identity:	54/239 - (22%)
Similarity:	93/239 - (38%)	Gaps:	49/239 - (20%)

- Green bases have known domain annotations that are detailed below.

Human     5 DRPE---KLFIGGLNLKTDEKALKAEFGKYGHIIKVFLMKDR-----KTNKSRGFAFVTFESPAD 61
            |.||   .||:..||.||.::.::..|...|.|..|.:.|.|     :..||.|:.|:.|:..:.
  Fly   673 DEPEPNTTLFLRNLNFKTVQETVEKHFRHLGSIHTVEIAKRRDPENPREFKSLGYGFIQFKKSSV 737

Human    62 AKAAARDMNGKYLDGKAIMVAQTIKPAFKSSRWVPPTPGSGSRSRFSHRTRGGGSS--PQRPPSQ 124
            |:.|.:::...::||..:.:.       :|.|.:......|::.|.:.:.:..|:.  .:..|.|
  Fly   738 AEHALKNLQLTHIDGNPVELK-------RSDRVLKTQDNDGAQRRLASQKKQTGTKILVRNIPFQ 795

Human   125 GRPDDGRG-YAGYFDLWPYRAPMPRKRGPPPRHWASPPHKRATPSSLAHSVGCGM---RGKAPTV 185
            .:..:.|. :..:.:|...|.|                 |:||....||. |.|.   ..||...
  Fly   796 AQYREVRDIFKAFGELRSLRIP-----------------KKATTGEDAHR-GFGFVDYMSKAEAK 842

Human   186 SGQDGYSG---LQPRR----WAGPPHKRAVP---RSSLARIGGS 219
            ...|..|.   |..||    |:.....:.|.   :.:.|:..||
  Fly   843 RAFDALSASTHLYGRRLVLEWSANDDNQDVEELRKRTAAKFDGS 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RBMXL3	NP_001138818.1	RRM	<1..>81	CDD:223796	24/83 (29%)
		RRM_RBMX_like	7..86	CDD:240828	23/86 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..131		7/42 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..175		6/30 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..305
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	357..1067
CG3335	NP_648337.1	RRM1_RBM19	2..77	CDD:241008
		RRM_SF	250..314	CDD:302621
		RRM3_RBM19	362..440	CDD:241011
		RRM4_RBM19	552..623	CDD:241013
		RRM	<638..845	CDD:223796	44/196 (22%)
		RRM5_RBM19_like	679..760	CDD:240764	21/87 (24%)
		RRM6_RBM19	785..864	CDD:241015	20/96 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910