DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RBMXL3 and rsp-4

DIOPT Version :9

Sequence 1:	NP_001138818.1	Gene:	RBMXL3 / 139804	HGNCID:	26859	Length:	1067	Species:	Homo sapiens
Sequence 2:	NP_001379856.1	Gene:	rsp-4 / 173915	WormBaseID:	WBGene00004701	Length:	196	Species:	Caenorhabditis elegans

Alignment Length:	182	Identity:	55/182 - (30%)
Similarity:	81/182 - (44%)	Gaps:	33/182 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    10 LFIGGLNLKTDEKALKAEFGKYGHIIKVFLMKDRKTNKSRGFAFVTFESPADAKAAARDMNGKYL 74
            |.|..|:.:|....|:..|.:||.|..|.:.:|:.:.:|:||.||.|....||:.|....:||.:
Worm    21 LKIDNLSYQTTPNDLRRTFERYGDIGDVHIPRDKYSRQSKGFGFVRFYERRDAEHALDRTDGKLV 85

Human    75 DGKAIMV--AQTIKPA--------------FKSSRWVPPTPGSGSRSRFSHRTRGGGSSPQRPPS 123
            ||:.:.|  |:..:|:              .:|.|....:| ..||||...|:|   |..:.|||
Worm    86 DGRELRVTLAKYDRPSDERGGRGGGGGRRRSRSPRRRSRSP-RYSRSRSPRRSR---SRTRSPPS 146

Human   124 QGRPDDGRGYAGYFDLWPYRA--PMPRKRGPPPRHWASPPHKRATPSSLAHS 173
            :.|.|.           |.|.  ...|.|.||||...||..:|:...|.:.|
Worm   147 RDRRDS-----------PDRRDNSRSRSRSPPPREDGSPKERRSRSRSASRS 187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RBMXL3	NP_001138818.1	RRM	<1..>81	CDD:223796	24/70 (34%)
		RRM_RBMX_like	7..86	CDD:240828	26/77 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..131		15/40 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..175		11/32 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..305
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	357..1067
rsp-4	NP_001379856.1	RRM_SRSF2_SRSF8	21..93	CDD:409751	24/71 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910