Protein Alignment CRK and crk

DIOPT Version :10

• Sequence 1: NP_058431.2
• Gene: CRK / 1398
• HGNCID: 2362
• Length: 304
• Species: Homo sapiens
• Sequence 2: NP_001006107.1
• Gene: crk / 448023
• XenbaseID: XB-GENE-996357
• Length: 296
• Species: Xenopus tropicalis
• Alignment Length: 305
• Identity: 260/305 - (85%)
• Similarity: 279/305 - (91%)
• Gaps: 10/305 - (3%)

Human     1 MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINS- 64
            ||||||||:|:|||||:|:|||||.|||||||||||||||:|.||||||||||||:||||||||
 Frog     1 MAGNFDSEDRASWYWGKLNRQEAVNLLQGQRHGVFLVRDSTTIPGDYVLSVSENSKVSHYIINSV 65

Human    65 SGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSRSRQGSGVIL 129
            |..|        |...|:..||.|||||||||||:||||||||||||||||||||:|:| ||||.
 Frog    66 SNNR--------QSGTGMIQSRFRIGDQEFDSLPSLLEFYKIHYLDTTTLIEPVSKSKQ-SGVIQ 121

Human   130 RQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPAS 194
            ||||.|||||||||||||:||||||||||||||||||||||||||::|:||||||||||||||.|
 Frog   122 RQEEVEYVRALFDFNGNDDEDLPFKKGDILRIRDKPEEQWWNAEDNDGRRGMIPVPYVEKYRPPS 186

Human   195 ASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYARVIQKRVPNAYDKTALALE 259
            ::.|||||||||.|||||||||||||||||||||||||||||||:||||||||||||||||||||
 Frog   187 SAGSALIGGNQENSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIFARVIQKRVPNAYDKTALALE 251

Human   260 VGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLLDQQNPDEDFS 304
            ||:||||||||||||||||||||.||||||||||||||||:||||
 Frog   252 VGDLVKVTKINVSGQWEGECNGKYGHFPFTHVRLLDQQNPEEDFS 296

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CRK	NP_058431.2	SH2_CRK_like	5..122	CDD:198180	89/117 (76%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	61..85		8/24 (33%)
		SH3_CRK_N	135..189	CDD:212692	49/53 (92%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..229		26/27 (96%)
		SH3_CRK_C	237..293	CDD:212693	52/55 (95%)
crk	NP_001006107.1	SH2_CRK_like	5..115	CDD:198180	89/117 (76%)
		SH3_CRK_N	127..181	CDD:212692	49/53 (92%)
		SH3_CRK_C	229..285	CDD:212693	52/55 (95%)