DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CRK and crk

DIOPT Version :9

Sequence 1:	NP_058431.2	Gene:	CRK / 1398	HGNCID:	2362	Length:	304	Species:	Homo sapiens
Sequence 2:	NP_001006107.1	Gene:	crk / 448023	XenbaseID:	XB-GENE-996357	Length:	296	Species:	Xenopus tropicalis

Alignment Length:	305	Identity:	260/305 - (85%)
Similarity:	279/305 - (91%)	Gaps:	10/305 - (3%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINS- 64
            ||||||||:|:|||||:|:|||||.|||||||||||||||:|.||||||||||||:||||||||
Frog     1 MAGNFDSEDRASWYWGKLNRQEAVNLLQGQRHGVFLVRDSTTIPGDYVLSVSENSKVSHYIINSV 65

Human    65 SGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSRSRQGSGVIL 129
            |..|        |...|:..||.|||||||||||:||||||||||||||||||||:|:| ||||.
Frog    66 SNNR--------QSGTGMIQSRFRIGDQEFDSLPSLLEFYKIHYLDTTTLIEPVSKSKQ-SGVIQ 121

Human   130 RQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPAS 194
            ||||.|||||||||||||:||||||||||||||||||||||||||::|:||||||||||||||.|
Frog   122 RQEEVEYVRALFDFNGNDDEDLPFKKGDILRIRDKPEEQWWNAEDNDGRRGMIPVPYVEKYRPPS 186

Human   195 ASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYARVIQKRVPNAYDKTALALE 259
            ::.|||||||||.|||||||||||||||||||||||||||||||:||||||||||||||||||||
Frog   187 SAGSALIGGNQENSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIFARVIQKRVPNAYDKTALALE 251

Human   260 VGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLLDQQNPDEDFS 304
            ||:||||||||||||||||||||.||||||||||||||||:||||
Frog   252 VGDLVKVTKINVSGQWEGECNGKYGHFPFTHVRLLDQQNPEEDFS 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CRK	NP_058431.2	SH2_CRK_like	5..122	CDD:198180	89/117 (76%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	61..85		8/24 (33%)
		SH3_CRK_N	135..189	CDD:212692	49/53 (92%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..229		26/27 (96%)
		SH3_CRK_C	237..293	CDD:212693	52/55 (95%)
crk	NP_001006107.1	SH2_CRK_like	5..115	CDD:198180	89/117 (76%)
		SH3_CRK_N	127..181	CDD:212692	49/53 (92%)
		SH3_CRK_C	229..285	CDD:212693	52/55 (95%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	129	1.000	Domainoid score	I24452
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H81850
Inparanoid	1	1.050	528	1.000	Inparanoid score	I7333
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1414461at2759
OrthoFinder	1	1.000	-	-		FOG0003539
OrthoInspector	1	1.000	-	-		oto157040
Panther	1	1.100	-	-	LDO	PTHR19969
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2415
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.160