Protein Alignment PNCK and MAPk-Ak2

DIOPT Version :10

• Sequence 1: NP_001034671.3
• Gene: PNCK / 139728
• HGNCID: 13415
• Length: 426
• Species: Homo sapiens
• Sequence 2: NP_524769.1
• Gene: MAPk-Ak2 / 44573
• FlyBaseID: FBgn0013987
• Length: 359
• Species: Drosophila melanogaster
• Alignment Length: 263
• Identity: 101/263 - (38%)
• Similarity: 152/263 - (57%)
• Gaps: 18/263 - (6%)

Human   104 LGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISHPN-IVALEDVHESP- 166
            ||.|...:||....|.:....|||.:    |..:.|  ..|:.:..|:|... ||.:.||:|:.
  Fly    26 LGYGINGKVVQCTHRRTQQNYALKVL----LDSERA--RREVDLHWRVSGCRYIVNIIDVYENTF 84

Human   167 ---SHLYLAMELVTGGELFDRIMER--GSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLL 226
               ..|.:.||.:.|||||.||.::  |::||::|:.::.::..||.||||..|.||||||||||
  Fly    85 KDRKCLLVVMECMEGGELFQRIQDKADGAFTEREAAQIMHEICAAVDYLHSRDIAHRDLKPENLL 149

Human   227 YATPFEDSKIMVSDFGLSK-IQAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLC 290
            |.|...::.:.::|||.:| ......|.|.|.||.|||||:|..:.|.|:.|:|:|||:.||::|
  Fly   150 YTTTQPNATLKLTDFGFAKETFTSYTLQTPCYTPYYVAPEVLGPEKYDKSCDIWSLGVVMYIIMC 214

Human   291 GYPPFYDES----DPELFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALRHL 351
            |:||||...    .|.:.::|....|:|..|.|.::|::|||.|:.:|..||.||...|..:.:.
  Fly   215 GFPPFYSNHGLAISPGMKNRIRTGQYDFPDPEWTNVSQAAKDLIKGMLNVDPSKRLRIQDVISNK 279

Human   352 WIS 354
            ||:
  Fly   280 WIA 282

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PNCK	NP_001034671.3	STKc_CaMKI_beta	94..370	CDD:271071	101/263 (38%)
MAPk-Ak2	NP_524769.1	STKc_MAPKAPK	18..280	CDD:270991	99/259 (38%)