Protein Alignment GAB3 and Gab2

DIOPT Version :10

• Sequence 1: XP_011529405.1
• Gene: GAB3 / 139716
• HGNCID: 17515
• Length: 611
• Species: Homo sapiens
• Sequence 2: NP_445869.2
• Gene: Gab2 / 84477
• RGDID: 621367
• Length: 664
• Species: Rattus norvegicus
• Alignment Length: 698
• Identity: 231/698 - (33%)
• Similarity: 333/698 - (47%)
• Gaps: 146/698 - (20%)

Human     1 MSAG--DAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLS 63
            ||.|  |.||||||.|||||:||:||||:||||:||.|||||:|||||||:|:||.||:|:|:|:
  Rat     1 MSGGGDDVVCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNEHSKKPLRIINLN 65

Human    64 ECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGHLEDGAADS 128
            .|. ....|.:|.:||.|::|||.:||:.|||||||:||.:|..||.||.|:|.....|: :.||
  Rat    66 FCE-QVDAGLTFNKKELQDSFVFDIKTSERTFYLVAETEADMNKWVQSICQICGFNQAEE-STDS 128

Human   129 MESL---SYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLFL-----PDYL 185
            :.:|   |:.|.|.....:||........||.|...........|...|......|     .:||
  Rat   129 LRNLSSASHGPRSSPAEFSSSQHLLRERKSSAPSHSSQPTLFTFEPPMSSHMQPALSTSAPQEYL 193

Human   186 VLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVD---CLQ------------PLPSSHL 235
            .|..|.:.|..:    :|..|:|...|.....:...:...   |:.            |.||.|.
  Rat   194 YLHQCISRRTEN----SRSASFSQGTRQKSDTAVQKLAQSNGHCINGVSNQVHGFYSLPKPSRHN 254

Human   236 VH--------P---SCHGSGAQEVPSSRPQAALIWS---------REINGPPRDHLS--SSPLLE 278
            ..        |   :.||.....:..|......:::         ||......|::.  ::||..
  Rat   255 TEFKDSTYDLPRSLASHGHTKSSLTGSETDNEDVYTFKMPSNTLCREFGDLLVDNMDVPTTPLSA 319

Human   279 SSLSSTIQVDKNQGSLPCGAKELDIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPE------- 336
            ..:..|..:|||..::.........::  |||||||||.....|   |.  |..:||.
  Rat   320 YQIPRTFTLDKNHNAMTVATSGDSAIA--PPPRPPKPSQAETPR---WG--SPQQKPPIGENSRS 377

Human   337 -CTLVPRRISLSGLDNMR---------------------TWKADVEGQSLRHRDKRLSLNLPCRF 379
             ...:|||.:|..:||.|                     :|.|:..|::...|..
  Rat   378 VAATIPRRNTLPAMDNSRLHRASSCETYEYPTRGSGESASWSAESPGKTAVGRSN---------- 432

Human   380 SPMYPTASASIEDSYVPMSPQAGASGL------GPHCSPDDYIPMNSG----------SISSPL- 427
                   |||.:|:||||:|  |:|.|      |.: |...||||:.|          |.:.|:
  Rat   433 -------SASSDDNYVPMNP--GSSTLLAMERAGDN-SQSAYIPMSPGPHHFDPLGYPSTALPIH 487

Human   428 --PELPANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIRE---HASLTRT-----RTVPCSRTSFL 482
              |...:.::||||||:|||.||::|.||||||.::|.|   .:.:|::     .|...|.:.:.
  Rat   488 RGPSRGSEIQPPPVNRNLKPDRKAKPTPLDLRNNTVIDELPFKSPVTKSWSRINHTFNSSSSQYC 552

Human   483 SPERNGINSARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKK---FSLDYLALDFNSASP 544
            .|     .|.:...:..|.:.||:|:.|:...:||.:.||..:...:   .|:|||||||...||
  Rat   553 RP-----ISTQSITSTDSGDSEENYVPMQNPVSASPVPSGTNSPAPRKSTGSVDYLALDFQPGSP 612

Human   545 APMQQKLL--LSEEQRVDYVQVDEQKTQALQSTKQEWTDERQSKVKTK 590
            :|.::...  ::.:::|||||||::||||||:|.|||||.|||...:|
  Rat   613 SPHRKPSTSSVTSDEKVDYVQVDKEKTQALQNTMQEWTDVRQSSEPSK 660

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GAB3	XP_011529405.1	PH_Gab3	1..125	CDD:270184	75/125 (60%)
Gab2	NP_445869.2	PH-like	5..127	CDD:473070	72/123 (59%)
		Plasmodium_Vir	<541..>627	CDD:329056	24/90 (27%)