Protein Alignment GAB3 and gab3

DIOPT Version :9

• Sequence 1: XP_011529405.1
• Gene: GAB3 / 139716
• HGNCID: 17515
• Length: 611
• Species: Homo sapiens
• Sequence 2: XP_001337715.6
• Gene: gab3 / 797259
• ZFINID: ZDB-GENE-070705-270
• Length: 633
• Species: Danio rerio
• Alignment Length: 631
• Identity: 279/631 - (44%)
• Similarity: 348/631 - (55%)
• Gaps: 121/631 - (19%)

Human     1 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLSEC 65
            |||||.||||||:|||||:||:|::||||||||||||||||||||||||:|.|.||||.|||.||
Zfish    78 MSAGDVVCTGWLIKSPPEKKLKRFSWRKRWFVLRRGRMSGNPDVLEYYRSKSSRKPIRTIDLQEC 142

Human    66 AVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGHLEDGAADSME 130
            .|.........:::.||..:|:|||.:|.|||:|||.:||..||.:|.|:|..|.| :..|:||:
Zfish   143 EVTIEAEVRPTKRQHQNQHLFVVKTATRIFYLLAKTAEEMNDWVQNIGQICTFGGL-NRHAESMD 206

Human   131 SLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEET-----------RSESELLFLPDY 184
            ||:.||||.|||.|.|               |:.:.||.::|           .||||.....||
Zfish   207 SLNRTPSSQQPSPALS---------------PHVSLVANQDTVTVDNHAVLDRPSESESSPPLDY 256

Human   185 LVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQAS---FDDVF--VDCLQPLPSSHLVHPSCHGSG 244
            |.||.||||    |....||||.|||:||.||:|   .:|||  ...:...||..|:      :|
Zfish   257 LFLSQCETG----TKSIVRCDSISNSERSFEQSSSEYTEDVFSPTPRIDTSPSPFLL------TG 311

Human   245 AQEVPSSRPQAALIWSREINGPPRDHLSSSPLLESSLSSTIQV--------DKNQGSLPCGAKEL 301
            ..|.|.|.|..              .||.|..|.|.|||.|.:        |:    |.|.|.|
Zfish   312 VSEPPFSAPCG--------------QLSVSSSLSSCLSSPISLRPPDIFRFDR----LFCVASE- 357

Human   302 DIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVEGQSLRH 366
               ..||||.||||:|||::...| .|.....:|  .|:|||.|||.:|:.|..:.|..|   |:
Zfish   358 ---PQTPPPLPPKPTHLSDQHSNE-DTSRNQSQP--ALLPRRTSLSAIDHFRRGEFDSSG---RN 413

Human   367 RDKRLSLNLPCRFSPMYPTASASIEDSYVPM-SPQAGASGLGPHCSPDDYIPMNSGSISSPL--- 427
            .:||||||||. |.....|.: ..||||||| ||....:.:    :.|.||||:..::...|
Zfish   414 WNKRLSLNLPI-FQNTTVTEN-HCEDSYVPMASPPISCTDV----TSDGYIPMSPSTLPVSLLTN 472

Human   428 --PELPA----NLEPPPVNRDLKPQRKSRPPPLDLRNLSIIRE---HASLTRTRTVPCSRTSFLS 483
              ||||:    :||||||:|:||| |:.||||||||.||.|.|   |..|||..|.|
Zfish   473 GKPELPSPSNPDLEPPPVDRNLKP-RRPRPPPLDLRGLSTISECPFHVPLTRAMTEP-------- 528

Human   484 PERNGINSARFFANPVSR--------EDEESYIEMEEHRTASSLSSGALTWTKKFSLDYLALDFN 540
                   |......|:.|        .:::..|...:.|.....|..:..|.:...||||:||||
Zfish   529 -------STSLQCTPLDRRRVWCLNGSEQDGSITPTDSRQMLFPSCDSAPWMRPSQLDYLSLDFN 586

Human   541 SASPAPMQQKLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQSK 586
            ||||:|:|:|.||::|.|||||:|||:|||||||||.||.|.||||
Zfish   587 SASPSPVQKKPLLADEYRVDYVKVDEKKTQALQSTKMEWKDVRQSK 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GAB3	XP_011529405.1	PH_Gab3	1..125	CDD:270184	77/123 (63%)
		PH	7..116	CDD:278594	69/108 (64%)
gab3	XP_001337715.6	PH-like	78..198	CDD:327399	76/119 (64%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H15417
Inparanoid	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153633at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	6	6.420