Protein Alignment GAB3 and dos

DIOPT Version :10

• Sequence 1: XP_011529405.1
• Gene: GAB3 / 139716
• HGNCID: 17515
• Length: 611
• Species: Homo sapiens
• Sequence 2: NP_523890.2
• Gene: dos / 38321
• FlyBaseID: FBgn0016794
• Length: 878
• Species: Drosophila melanogaster
• Alignment Length: 889
• Identity: 187/889 - (21%)
• Similarity: 307/889 - (34%)
• Gaps: 345/889 - (38%)

Human    10 GWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPD--VLEYYRNKHSSKPIRVIDLSECAVWKHV- 71
            |||:||||.:::.|..||:|:|.|::|.:   |:  .||||.:.:..|...||||.:|   :.|
  Fly     8 GWLIKSPPTKRIWRARWRRRYFTLKQGEI---PEQFCLEYYTDHNCRKLKGVIDLDQC---EQVD 66

Human    72 -GPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGHLED---------GAA 126
             |.....::.:..::|.:||..||:||.|:||.:|:.||:.|.|||   ||.|         ||.
  Fly    67 CGLRLENRKQKFQYMFDIKTPKRTYYLAAETEADMRDWVNCICQVC---HLHDTKQSNELPLGAV 128

Human   127 DSMES-LSYTPSSLQPSSASSLLTAHAASSSLPRDDPNT---NAVATEETRSESELLFLPDYLVL 187
            .:.|: ..:|.||...|:::...|..:..||.....|..   ||..:.:.|..:.:...|   :.
  Fly   129 GADENRTQHTSSSGGLSNSTQNTTTTSLHSSAGTTAPQASVPNAGGSAQLRRPAVIEEQP---MP 190

Human   188 SNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDD---VFVDCLQPLPS---------SHLVHPSC 240
            ||..........:.|   .:||.:..|..|:||.   :.....||.||         |.|:....
  Fly   191 SNAGNNNSDSVYVNT---EYSNRETMLCDANFDQQELLSAAQQQPPPSPATALYLNHSALIQAQA 252

Human   241 HGSGAQEVPSSRPQAALIWSREINGPPR---DHL------------------SSSPLLESSLSST 284
            ..:.|:::...:.|||.: :...||..|   :||                  .:||.|.::....
  Fly   253 AAAAAEQLQQQQQQAARL-AVSANGVVRKLPEHLVLTQQTLAEAAAQQHSSVQASPALSTASGPY 316

Human   285 IQVDK-NQGS------LPCGAKELDIMSN--TP----------PPR---------------PPKP 315
            |.:.: ..||      :|....:|.|.:|  ||          .||               .||.
  Fly   317 IPISECFSGSPRFLPGVPLPGADLAIPNNPTTPLNNLDPKFYDTPRSHNNIGLNLTNDQSYSPKI 381

Human   316 SHLSERR---------------------QEEWS---------------------------THSG- 331
            ::||.::                     .:||:                           |:|.
  Fly   382 TNLSLQQLANNNASKQRSDSDSESVFTDDDEWAHPLPLRENVDRSTRPSDSSIENESFVLTYSQR 446

Human   332 -SKKPE--CTLVP---RRISLSGLDNMRTWKADVEG------QSLRHR---------DKRLSLNL 375
             ||.||  ..:||   :...|:|..::.  :|..:|      :.|:::         ::::..:|
  Fly   447 FSKMPEEGGAIVPPAEKSSKLAGAASLP--EAGDQGTLDKLAKVLKNKNNLILDFKENEKIPRDL 509

Human   376 PCRFSPMYPTA----------SASIEDSY-VPMSPQAGASGLGPHCSPDDYI-------PMNSGS 422
            | :.|....|:          ||.||:|| :|.|.|.      |:.:.:..:       |.||..
  Fly   510 P-QLSDTENTSPAIVARRNAHSAFIEESYDIPRSHQQ------PYYNVNQLLGERPVTSPHNSNP 567

Human   423 ISSPLPELPA----------------------------------------NLEP----------- 436
            |::..|.|.|                                        |..|
  Fly   568 IAASTPNLMAADLGAVAAISAAANPGLMGEAQAVASSPTSARTLPRHCYTNAAPTKMEGNVFRYD 632

Human   437 -------PPVNRDLKP-------------------------------------QRKSRPPPLDLR 457
                   |||||.|||                                     |:...||.:|.:
  Fly   633 FMEQADCPPVNRKLKPKVAGGLPVVEDKPPEEFPAKPPVGVDQLTNKLGAAQLQQPIGPPSVDRK 697

Human   458 ---NLSIIREHASLT-RTRTVPCSRTSFLSPERNGINSA----RFF--ANPVSREDEESY----- 507
               |...:...|::: .||....:..|.:.|....::|.    .||  ...:.|:....:
  Fly   698 CKPNAYKLGNSATMSPATRRSSGAPLSMVLPHETDVHSPAAANAFFHETRTLPRQQHRHHPNSPG 762

Human   508 -IEMEEHRTAS------SLSSGALTWTK-----KFSLDYLALDFNSASP----APMQQKLLLSE- 555
             :.::..||||      ||::.|....:     :..|.|..||..:..|    :.|....|.|:
  Fly   763 SMSVQHQRTASAAAAMMSLTAAAAPKQQAAAQTEHKLQYFDLDVTNKPPLLNRSSMSVGNLYSQG 827

Human   556 ---------------------EQRVDYVQVDEQKTQALQSTKQE 578
                                 ...|.|..||..||:|.:..::|
  Fly   828 GNGASGMRFAGVEAGGARAPVPSSVVYRSVDFVKTEAFKRIREE 871

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GAB3	XP_011529405.1	PH_Gab3	1..125	CDD:270184	47/127 (37%)
dos	NP_523890.2	PH_Gab2_2	2..115	CDD:241535	45/115 (39%)