Protein Alignment GAB3 and Gab3

DIOPT Version :9

• Sequence 1: XP_011529405.1
• Gene: GAB3 / 139716
• HGNCID: 17515
• Length: 611
• Species: Homo sapiens
• Sequence 2: NP_853615.1
• Gene: Gab3 / 210710
• MGIID: 2387324
• Length: 595
• Species: Mus musculus
• Alignment Length: 600
• Identity: 456/600 - (76%)
• Similarity: 509/600 - (84%)
• Gaps: 18/600 - (3%)

Human     1 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLSEC 65
            ||.||.||.|||:||||||||||||||||||||||||||||||||||||||||:|||||||||||
Mouse     1 MSTGDTVCMGWLIKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSNKPIRVIDLSEC 65

Human    66 AVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGHLEDGAADSME 130
            .||||.||.|:|||||.||||||||||||||||||||:||||||||||||||..||||| |||||
Mouse    66 TVWKHAGPGFIRKEFQKNFVFIVKTTSRTFYLVAKTEEEMQVWVHSISQVCNFSHLEDG-ADSME 129

Human   131 SLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLFLPDYLVLSNCETGRL 195
            |||:.|||.|||.||||.|.|.|:|:|.:||.|||:|.|||||.|||.|||||||:|||||||||
Mouse   130 SLSHMPSSFQPSPASSLHTVHVANSALLKDDRNTNSVVTEETRRESEFLFLPDYLILSNCETGRL 194

Human   196 HHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSCHGSGAQEVPSSRPQAALIWS 260
            ||.||||||||||||:.||.|.||||||:|.|||..|::||||..||..:|:.||.||||:|||:
Mouse   195 HHASLPTRCDSWSNSNHSLAQTSFDDVFLDGLQPFISNNLVHPLHHGKVSQDFPSIRPQASLIWN 259

Human   261 REINGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKELDIMSNTPPPRPPKPSHLSERRQEE 325
            ||||||.|:.:||||||||||:.|:.|::.|.|||.|.|||:||||||||||||||:|||:||::
Mouse   260 REINGPSRNLMSSSPLLESSLNPTVHVEEKQVSLPSGVKELNIMSNTPPPRPPKPSYLSEQRQDQ 324

Human   326 --WSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVEGQSLRHRDKRLSLNLPCRFSPMYPTASA 388
              .:.||.:|||..|:|||||||||||::.:||.||:.||||||||||||||||:|||:|||||.
Mouse   325 PLLTGHSSNKKPGYTMVPRRISLSGLDHVGSWKGDVQSQSLRHRDKRLSLNLPCKFSPIYPTASP 389

Human   389 SIEDSYVPMSPQAGASGLGPHCSPDDYIPMNSGSISSPLPELPANLEPPPVNRDLKPQRKSRPPP 453
            |.|||||||||:..||.|.||||.||||||:    ||.||||||:||||||||:|||||||||||
Mouse   390 SAEDSYVPMSPKGTASELRPHCSQDDYIPMS----SSMLPELPADLEPPPVNRNLKPQRKSRPPP 450

Human   454 LDLRNLSIIREHASLTRTRTVPCSRTSFLSPERNGINSARFFANP-----------VSREDEESY 507
            ||.||||.|:||.|||||.||||:|||||||:|||||.||.|:.|           ...|:||.|
Mouse   451 LDSRNLSTIQEHTSLTRTYTVPCNRTSFLSPQRNGINCARLFSTPSEEEEEEEEEEEEEEEEEKY 515

Human   508 IEMEEHRTASSLSSGALTWTKKFSLDYLALDFNSASPAPMQQKLLLSEEQRVDYVQVDEQKTQAL 572
            |:|||:.|.||||..||:||||||||||||||||.||||:|:|||||||||||||||||||||||
Mouse   516 IQMEEYGTVSSLSRSALSWTKKFSLDYLALDFNSTSPAPVQKKLLLSEEQRVDYVQVDEQKTQAL 580

Human   573 QSTKQEWTDERQSKV 587
            :||||||||||||||
Mouse   581 RSTKQEWTDERQSKV 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GAB3	XP_011529405.1	PH_Gab3	1..125	CDD:270184	110/123 (89%)
		PH	7..116	CDD:278594	99/108 (92%)
Gab3	NP_853615.1	PH_Gab3	1..125	CDD:270184	111/124 (90%)
		PH	6..116	CDD:278594	99/109 (91%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	295..339		28/43 (65%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	389..408		12/18 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	418..463		37/48 (77%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	493..513		2/19 (11%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83952609
Domainoid	1	1.000	695	1.000	Domainoid score	I3851
eggNOG	1	0.900	-	-		E1_28MHG
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15417
Inparanoid	1	1.050	922	1.000	Inparanoid score	I6567
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG40208
OrthoDB	1	1.010	-	-		D1153633at2759
OrthoFinder	1	1.000	-	-		FOG0002466
OrthoInspector	1	1.000	-	-		oto128027
orthoMCL	1	0.900	-	-		OOG6_120503
Panther	1	1.100	-	-	LDO	PTHR45960
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6616
SonicParanoid	1	1.000	-	-		X12699
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	19	19.300