Protein Alignment GAB3 and soc-1

DIOPT Version :10

• Sequence 1: XP_011529405.1
• Gene: GAB3 / 139716
• HGNCID: 17515
• Length: 611
• Species: Homo sapiens
• Sequence 2: NP_504250.2
• Gene: soc-1 / 178855
• WormBaseID: WBGene00004928
• Length: 430
• Species: Caenorhabditis elegans
• Alignment Length: 594
• Identity: 121/594 - (20%)
• Similarity: 197/594 - (33%)
• Gaps: 223/594 - (37%)

Human    20 KLQRYAWRKRWFVLRRGRMSGNPDVLEYYR--NKHSSKP-------IRV---IDLSECAVWKHVG 72
            ||.:..|.:.:|||.......|...::.::  .|:..|.       |||   :.:|:.::....|
 Worm    21 KLFKTKWVEHYFVLHCRDRERNLFAIDEFKTSRKNDLKKRFKLEFVIRVESNLSVSDPSILCTAG 85

Human    73 PSFVRKEFQNNFVFIV----KTTSRTFYLVAKTEQEMQVWVHSISQVCNLGHLEDGAADSMESLS 133
            ... ::|...|.:|.|    :...:..|||||.::||.:||:.|.::|.| |.:....||..:..
 Worm    86 GGH-QEESMLNCIFGVGFRFENIVKDLYLVAKNDEEMTLWVNEICKLCKL-HRQHDEGDSSHAAE 148

Human   134 YTPSSLQPSSAS---SLLTAHAASSSLPRDDPNTNAVATEETRSESELLFLPDYLVLSNCETGRL 195
            .:.|.:..||.|   |::.....:.::|                ||:             :..|:
 Worm   149 SSISGMSMSSQSLDMSIIEQQQYAENIP----------------ESK-------------QYHRM 184

Human   196 HHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSCHGSGAQEVPSSRPQAALIWS 260
            ||                     |..|.         ||...||                    :
 Worm   185 HH---------------------FKSVI---------SHNSLPS--------------------N 199

Human   261 REINGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKELDIMSNTPPPRPPKPSHLSERRQEE 325
            ...|..| |.|.||....||:.|:.:.:.:..|...|          ||..||:..|...|..:.
 Worm   200 PNYNNLP-DPLESSRSETSSMYSSRRTEDDSVSYTSG----------PPVPPPRTRHTLNRFVKN 253

Human   326 WSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVEGQSLRHRDKRLSLNLPCRFSPMYPTASASI 390
            .........|..|.:.:.:.:...:       |..|::|:       |:.|    ..||.:..|.
 Worm   254 GQVGRLHMIPASTSMGQVVKVEDAE-------DSSGETLK-------LDTP----EQYPESVTSS 300

Human   391 EDSYVPMSPQAGASGLGPHCSPDDYIPMNSGSISSPLPELPANLEPPPVNRDLKPQRKSRPPPLD 455
            |.  .|:..:.|.:.:                          ...||||:|..||:        :
 Worm   301 EG--FPVYERNGKTLI--------------------------RRAPPPVDRSNKPK--------N 329

Human   456 LRNLSIIREHASLTRTRTVPCSRTSFLSPERNGIN-----SARFFANPVSREDEES-------YI 508
            ||.     |..:.||.|.:          .|||:|     ||.|.:...:.:..|:       |.
 Worm   330 LRG-----EEEAGTRYRNL----------SRNGVNENGNYSATFSSRTSNYQQSETSKRRNLDYF 379

Human   509 EMEEHRTASSLSSGALTWTKKFSLDYLALDFNSASPAPMQQKLLLSEEQRVDYVQVDEQKT---- 569
            |..:....||||:.|.|.|:              ||.|..          ::|:.||..:|
 Worm   380 EPTQMIENSSLSTLAATSTR--------------SPTPSD----------IEYISVDVDRTLAFK 420

Human   570 ---QALQST 575
               :|.|||
 Worm   421 QMRRAAQST 429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GAB3	XP_011529405.1	PH_Gab3	1..125	CDD:270184	31/120 (26%)
soc-1	NP_504250.2	PH	8..133	CDD:214574	28/112 (25%)