Protein Alignment GAB3 and gab3

DIOPT Version :10

• Sequence 1: XP_011529405.1
• Gene: GAB3 / 139716
• HGNCID: 17515
• Length: 611
• Species: Homo sapiens
• Sequence 2: XP_002931829.2
• Gene: gab3 / 100486768
• XenbaseID: XB-GENE-948841
• Length: 582
• Species: Xenopus tropicalis
• Alignment Length: 604
• Identity: 349/604 - (57%)
• Similarity: 431/604 - (71%)
• Gaps: 39/604 - (6%)

Human     1 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLSEC 65
            ||:||.||||||:|||||:||:||.||:|||||||||||||||||||||||:|.||||||||::|
 Frog     1 MSSGDVVCTGWLIKSPPEKKLKRYIWRRRWFVLRRGRMSGNPDVLEYYRNKNSKKPIRVIDLNDC 65

Human    66 AVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGHLEDGAADSME 130
            .|.|::|.:.::|||:|:|||||||..|||||||:||:|||.||::|:|:||.|.|||| .||:|
 Frog    66 EVQKYIGVNLIKKEFENSFVFIVKTIQRTFYLVARTEEEMQSWVNNITQICNFGQLEDG-TDSVE 129

Human   131 SLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLFLPDYLVLSNCETGRL 195
            |||:|.||:|.|.|.|..|:.....|...|..:.: :.:||.|||||.:|:||||.|||||:|:|
 Frog   130 SLSHTNSSVQASPAVSTHTSRITDPSFSVDSASAD-ITSEENRSESESIFIPDYLFLSNCESGKL 193

Human   196 HHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSCHGSGAQEVPSSRPQAALIWS 260
            :    ..|||:||||::||||.|.||||:|.:|   |.|..:.:..|.....  ::.|.|:||..
 Frog   194 N----SARCDAWSNSEKSLEQTSTDDVFLDSVQ---SQHSHNQTLFGVNPNH--NNMPPASLIMV 249

Human   261 REI--NGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKELDIMSNTPPPRPPKPSHLSERRQ 323
            :::  ||...|..||||||..|:..|..||....|      :.:::..|||||||||:|.||.|.
 Frog   250 KDLDSNGSSSDFSSSSPLLGPSVPQTFSVDYTIIS------DGEVLPITPPPRPPKPNHFSEGRP 308

Human   324 EEWS---THSGSKKPECTLVPRRISLSGLDNMRTWKADVEGQSLRHRDKRLSLNLPCRFSPMYPT 385
            |..|   ..:|...|  .:||||||||.|||:|.|:.::|..|||.|||||||||| ||:|:|..
 Frog   309 EVISIGNLQNGHFFP--GMVPRRISLSSLDNVRNWRGELEDWSLRTRDKRLSLNLP-RFAPLYSL 370

Human   386 ASASIEDSYVPMSPQAGASGLGPHCSPDDYIPMN------------SGSISSPLPELPANLEPPP 438
            .|.|.|||||||:|.|........||.|.||||:            :..:||||||||.:|||||
 Frog   371 TSESSEDSYVPMNPNASPPASESDCSTDGYIPMSPVTAAFPFQSPVNSKVSSPLPELPTDLEPPP 435

Human   439 VNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTSFLSPERNGINSARFFANPVSRED 503
            |||||||:||.|||||||||||.|||||.|||..|||.:||||.|||.:.||||..|:.....||
 Frog   436 VNRDLKPRRKMRPPPLDLRNLSTIREHAPLTRMWTVPYNRTSFTSPESDCINSAGIFSGSGFGED 500

Human   504 EESYIEMEEHRTASSLSSGALTWTKKFSLDYLALDFNSASPAPMQQKLLLSEEQRVDYVQVDEQK 568
             .:||:| |||..:|..:|:..|.:||:|||||||||||||:|:|:|..||||||||||||||:|
 Frog   501 -VTYIQM-EHRQGTSPVNGSFPWPRKFNLDYLALDFNSASPSPVQKKPFLSEEQRVDYVQVDEKK 563

Human   569 TQALQSTKQEWTDERQSKV 587
            |||||:|||||||||||||
 Frog   564 TQALQNTKQEWTDERQSKV 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GAB3	XP_011529405.1	PH_Gab3	1..125	CDD:270184	90/123 (73%)
gab3	XP_002931829.2	PH-like	1..125	CDD:473070	91/124 (73%)