DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CRIP2 and Mlp84B

DIOPT Version :9

Sequence 1:	NP_001257766.1	Gene:	CRIP2 / 1397	HGNCID:	2361	Length:	282	Species:	Homo sapiens
Sequence 2:	NP_001303418.1	Gene:	Mlp84B / 40849	FlyBaseID:	FBgn0014863	Length:	495	Species:	Drosophila melanogaster

Alignment Length:	191	Identity:	64/191 - (33%)
Similarity:	82/191 - (42%)	Gaps:	28/191 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    89 AEKVSSLGKDWHKFCLKCERCSKTLTPGGHAEHDGKPFCHKPCYATLFGPKGVNIGGAGSYIYEK 153
            ||::.:.|:.|||.|.||..|.|.|......|...|....|.|||..|||||...|..|..:...
  Fly   130 AEQMLARGRSWHKECFKCGTCKKGLDSILCCEAPDKNIYCKGCYAKKFGPKGYGYGQGGGALQSD 194

Human   154 PLAE---GPQVTGPIEVPAARAEERKASGPPKGPSRASSVTTFTGEPNTCPRCSKKVYFAEKVTS 215
            ..|.   .||:...|:|...:|.      |.:|                ||||...||.||:..|
  Fly   195 CYAHDDGAPQIRAAIDVDKIQAR------PGEG----------------CPRCGGVVYAAEQKLS 237

Human   216 LGKDWHRPCLRCERCGKTLTPGGHAE-HDGQPYCHKPCYGILFGPKGVNTGAVGSYIYDRD 275
            .|::||:.|..|:.|.|||.....:: .|...|| :.|||..:||.|... |.||.....|
  Fly   238 KGREWHKKCFNCKDCHKTLDSINASDGPDRDVYC-RTCYGKKWGPHGYGF-ACGSGFLQTD 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CRIP2	NP_001257766.1	LIM	89..132	CDD:295319	15/42 (36%)
CRIP2	NP_001257766.1	LIM_TLP_like	200..253	CDD:188785	21/53 (40%)
Mlp84B	NP_001303418.1	LIM1_MLP84B_like	11..64	CDD:188788
		LIM_CRP_like	120..173	CDD:188712	15/42 (36%)
		LIM_CRP_like	222..275	CDD:188712	21/53 (40%)
		LIM_CRP_like	325..378	CDD:188712
		LIM_CRP_like	421..474	CDD:188712
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1700
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1214165at2759
OrthoFinder	1	1.000	-	-		FOG0000284
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X318
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820