Protein Alignment CRHR2 and Dh31-R

DIOPT Version :9

• Sequence 1: NP_001189404.1
• Gene: CRHR2 / 1395
• HGNCID: 2358
• Length: 438
• Species: Homo sapiens
• Sequence 2: NP_001260951.1
• Gene: Dh31-R / 36475
• FlyBaseID: FBgn0052843
• Length: 604
• Species: Drosophila melanogaster
• Alignment Length: 431
• Identity: 121/431 - (28%)
• Similarity: 206/431 - (47%)
• Gaps: 78/431 - (18%)

Human    42 PLWALLEQYCHTIMT----LTNLSGP----YSYCNTTLDQIGTCWPRSAAGALVERPCPEYFNGV 98
            |.:..|...|.|.:.    |....||    .::|..|.|. ..|||.:|.|......||::..|
  Fly    35 PDFDALRAACETRLNASGQLAGSGGPGAEAGTHCAGTFDG-WLCWPDTAVGTSAYELCPDFITG- 97

Human    99 KYNTTRNAYREC----------LENGTWASKINYSQCEPILDDKQRKYDLHYRIAL-VVNYLGHC 152
             ::..|.|::||          |.|.||:   ||:.|..:       .||::|..: :::.:|:.
  Fly    98 -FDPARYAHKECGLDGEWFKHPLTNKTWS---NYTTCVNL-------EDLNWRHTVNLISEVGYG 151

Human   153 VSVAALVAAFLLFLALRSIRCLRNVIHWNLITTFILRN---VMWFLLQLVDHEVHESNEVWCRCI 214
            .|:.|::.:..:....:|::|.|..:|.||..:|...|   ::|:||.:.:.|:...:.:.|..:
  Fly   152 TSLLAILLSLAILGYFKSLKCARITLHMNLFASFAANNSLWLVWYLLVMPNSELLHQSPMRCVAL 216

Human   215 TTIFNYFVVTNFFWMFVEGCYLHTAIVMTY-STERLRKCLFLFIGWCIPFPII----VAWAIGKL 274
            ....:||:::|:.||..||.||||.:|..: |.:||.|.|..| ||..|..:|    :|..:|..
  Fly   217 HITLHYFLLSNYSWMLCEGFYLHTVLVAAFISEKRLVKWLIAF-GWGSPAIVIFVYSMARGLGGT 280

Human   275 YYENEQCWFGKEPGDLVDY--IYQGPIILVLLINFVFLFNIVRILMTKLRASTT-------SETI 330
            ..:|..||..:     .:|  |...|:.:.:.:|.:||.||||:::.||.|..:       |.|:
  Fly   281 PEDNRHCWMNQ-----TNYQNILMVPVCISMFLNLLFLCNIVRVVLLKLNAPASIQGSCGPSRTV 340

Human   331 QYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRS 395
              .:|.:|||:|:||||:.|:|....|......:..:...::|..||||..|::.:||.||||.:
  Fly   341 --LQAFRATLLLVPLLGLQYILTPFRPAPKHPWENTYEIISAFTASFQGLCVAILFCFCNGEVIA 403

Human   396 AVRKRWHRWQDHHSLRVPMARAMSIPTSP-------TRISF 429
            .::::|              |.|.....|       |::||
  Fly   404 QMKRKW--------------RMMCFSNRPRTNSYTATQVSF 430

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CRHR2	NP_001189404.1	HormR	63..134	CDD:214468	23/84 (27%)
		7tm_2	140..382	CDD:278432	76/259 (29%)
Dh31-R	NP_001260951.1	HRM	65..132	CDD:280888	22/72 (31%)
		7tm_4	140..390	CDD:304433	75/257 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2715
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840