DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CRHR1 and crhr1

DIOPT Version :9

Sequence 1:	NP_001138618.1	Gene:	CRHR1 / 1394	HGNCID:	2357	Length:	444	Species:	Homo sapiens
Sequence 2:	XP_696346.3	Gene:	crhr1 / 567940	ZFINID:	ZDB-GENE-081231-1	Length:	430	Species:	Danio rerio

Alignment Length:	460	Identity:	350/460 - (76%)
Similarity:	379/460 - (82%)	Gaps:	54/460 - (11%)

- Green bases have known domain annotations that are detailed below.

Human     4 HPQLRLVKALLLLGLNPVSASLQDQHCESLSLAS-------------------NISGLQCNASVD 49
            |||      :|.:.:..:|.:..|..|::|.|.|                   |.:||.||.|:|
Zfish     6 HPQ------VLTIWITLISRATADLTCDALLLLSTNLTARTLILWNQTSSPTTNSTGLFCNTSID 64

Human    50 LIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKV 114
            .||||||||.||::|.||||..|.|||||||||.||||||||:||.:.|||:||||||||||||:
Zfish    65 GIGTCWPRSSAGEVVSRPCPESFLGVRYNTTNNVYRECLANGTWAKKGNYSQCQEILNEEKKSKL 129

Human   115 HYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCL 179
            |||:|||||||||||||.||||||:||:||                             ||||||
Zfish   130 HYHIAVIINYLGHCISLGALLVAFILFMRL-----------------------------RSIRCL 165

Human   180 RNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHT 244
            |||||||||:||||||||||||||||:||||:|||.|||||||||||||||||||||||||||||
Zfish   166 RNIIHWNLITAFILRNATWFVVQLTMNPEVHESNVIWCRLVTAAYNYFHVTNFFWMFGEGCYLHT 230

Human   245 AIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVL 309
            |||||||||:|||||||||||.:|||||||||||||||||||||||||.|:||||||||||||||
Zfish   231 AIVLTYSTDKLRKWMFICIGWCIPFPIIVAWAIGKLYYDNEKCWFGKRAGIYTDYIYQGPMILVL 295

Human   310 LINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFI 374
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|::|||
Zfish   296 LINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEISQIVFI 360

Human   375 YFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIK 439
            ||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||
Zfish   361 YFNSFLESFQGFFVSVFYCFLNSEVRSAVRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIK 425

Human   440 QSTAV 444
            ||:||
Zfish   426 QSSAV 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CRHR1	NP_001138618.1	HormR	40..111	CDD:214468	52/70 (74%)
		Important for peptide agonist binding	99..108		7/8 (88%)
		7tm_2	116..388	CDD:278432	226/271 (83%)
		Important for antagonist binding	309..319		9/9 (100%)
crhr1	XP_696346.3	HormR	55..126	CDD:214468	52/70 (74%)
crhr1	XP_696346.3	7tm_2	131..374	CDD:278432	226/271 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194335191
Domainoid	1	1.000	433	1.000	Domainoid score	I3894
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20920
Inparanoid	1	1.050	710	1.000	Inparanoid score	I4179
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG46870
OrthoDB	1	1.010	-	-		D1163977at2759
OrthoFinder	1	1.000	-	-		FOG0002345
OrthoInspector	1	1.000	-	-		oto46010
orthoMCL	1	0.900	-	-		OOG6_103932
Panther	1	1.100	-	-	LDO	PTHR45620
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	16	16.410