DRSC/TRiP Functional Genomics Resources

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Protein Alignment CRHR1 and Dh31-R

DIOPT Version :9

Sequence 1:NP_001138618.1 Gene:CRHR1 / 1394 HGNCID:2357 Length:444 Species:Homo sapiens
Sequence 2:NP_001260951.1 Gene:Dh31-R / 36475 FlyBaseID:FBgn0052843 Length:604 Species:Drosophila melanogaster


Alignment Length:451 Identity:126/451 - (27%)
Similarity:199/451 - (44%) Gaps:109/451 - (24%)


- Green bases have known domain annotations that are detailed below.


Human    30 CES-LSLASNISGL---QCNASVDLIGT-----CWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYR 85
            ||: |:.:..::|.   ...|.....||     |||.:..|......||.|..|  ::.....::
  Fly    44 CETRLNASGQLAGSGGPGAEAGTHCAGTFDGWLCWPDTAVGTSAYELCPDFITG--FDPARYAHK 106

Human    86 EC----------LANGSWAARVNYSEC--QEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAF 138
            ||          |.|.:|:   ||:.|  .|.||..       |...:|:.:|:..||:|:|::.
  Fly   107 ECGLDGEWFKHPLTNKTWS---NYTTCVNLEDLNWR-------HTVNLISEVGYGTSLLAILLSL 161

Human   139 VLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQL 203
            .:.               |..              :|::|.|..:|.||.::|...|:.|.|..|
  Fly   162 AIL---------------GYF--------------KSLKCARITLHMNLFASFAANNSLWLVWYL 197

Human   204 TMSPE---VHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTY-STDRLRKWMFICIG 264
            .:.|.   :|||.:. |..:....:||.::|:.||..||.||||.:|..: |..||.||: |..|
  Fly   198 LVMPNSELLHQSPMR-CVALHITLHYFLLSNYSWMLCEGFYLHTVLVAAFISEKRLVKWL-IAFG 260

Human   265 WGVPFPII----VAWAIGKLYYDNEKCWFGKRPGVYTDY--IYQGPMILVLLINFIFLFNIVRIL 323
            ||.|..:|    :|..:|....||..||..:     |:|  |...|:.:.:.:|.:||.||||::
  Fly   261 WGSPAIVIFVYSMARGLGGTPEDNRHCWMNQ-----TNYQNILMVPVCISMFLNLLFLCNIVRVV 320

Human   324 MTKLRASTT-------SETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLE 381
            :.||.|..:       |.|:  .:|.:|||:|:||||:.|:|....|.........:...::|..
  Fly   321 LLKLNAPASIQGSCGPSRTV--LQAFRATLLLVPLLGLQYILTPFRPAPKHPWENTYEIISAFTA 383

Human   382 SFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSP-------TRVSF 435
            ||||..|::.:||.|.||.:.::::|              |.|.....|       |:|||
  Fly   384 SFQGLCVAILFCFCNGEVIAQMKRKW--------------RMMCFSNRPRTNSYTATQVSF 430

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CRHR1NP_001138618.1 HormR 40..111 CDD:214468 23/90 (26%)
Important for peptide agonist binding 99..108 4/10 (40%)
7tm_2 116..388 CDD:278432 86/288 (30%)
Important for antagonist binding 309..319 3/9 (33%)
Dh31-RNP_001260951.1 HRM 65..132 CDD:280888 18/71 (25%)
7tm_4 140..390 CDD:304433 86/287 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4564
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2715
SonicParanoid 1 1.000 - - X66
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.840

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