DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ces3b and Nrt

DIOPT Version :9

Sequence 1:	NP_653094.2	Gene:	Ces3b / 13909	MGIID:	3644960	Length:	571	Species:	Mus musculus
Sequence 2:	NP_001189121.1	Gene:	Nrt / 39873	FlyBaseID:	FBgn0004108	Length:	846	Species:	Drosophila melanogaster

Alignment Length:	545	Identity:	134/545 - (24%)
Similarity:	219/545 - (40%)	Gaps:	125/545 - (22%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MTNMRTMIPAGSSVLVWVTCLLLAFVTTVTGPKVIQPEVDTPLGRVRGRQV----------GVKD 55
            :|.:|....:....|:....||...:..|.|..:....:.:|..| .||.:          |||:
  Fly   312 LTRLRGYKCSVDDALIVFGILLFVLLLGVIGYVLTHETLTSPPLR-EGRYIMAVTGCGPVEGVKE 375

Mouse    56 TDRMVNVFLGIPFAQAPVGPLRFSAPLPPQPWEGVRDASINPPMCLQDVEKMINS------RFGL 114
            ....  .|.|||:|:.||..||:      :|.|.:.|  ||  ||..|..:..||      |.|.
  Fly   376 DGAF--AFRGIPYAKPPVDRLRW------KPAELIDD--IN--MCWNDTLQTHNSSVVCTQRLGN 428

Mouse   115 NEKIKIFPISEDCLTLNIYSPTEITAGDKRPVMVWIHGGSLLVGSSTS--QDGSALAAYGDVVVV 177
            ...:.    .||||.|::.:| .:...:..||:|.| |...|.|.|..  :..:..:...||:.|
  Fly   429 GTTVG----DEDCLYLDVVTP-HVRYNNPLPVVVLI-GAESLAGPSPGILRPSARYSRSHDVIFV 487

Mouse   178 TVQYRLGIFGFLS----TGDKHMP--GNRGFLDVVAALRWVQGNIAPFGGDPNCVTIFGNSAGGM 236
            ...:|||:||||:    |.:.|.|  ||....|::|.|.|::.||..|||||..||:.|:.||..
  Fly   488 RPNFRLGVFGFLALDALTKEAHPPTSGNYALTDIIAVLNWIKLNIVHFGGDPQSVTLLGHRAGAT 552

Mouse   237 IVSSLFLSPISAGLFHRAISQSGIVTTIMMEDMKPWPEA----QNFANSVACGSASPAELVQCLL 297
            :|:.|..|....||:.||.:.||  :.|:  ..||..|:    :....::.|..      :|||.
  Fly   553 LVTLLVNSQKVKGLYTRAWASSG--SAIL--PGKPLSESGKQNEQLMATLECAD------IQCLR 607

Mouse   298 QKEGK---------------DLIKQKNVNIS------YIVNDSFFPQRPEKLLADQQFPTVPYL- 340
            :...:               ||.:.:..|.|      .:::.....:.|......:|....|.|
  Fly   608 EASSERLWAATPDTWLHFPVDLPQPQEANASGSRHEWLVLDGDVVFEHPSDTWKREQANDKPVLV 672

Mouse   341 LGVTNHEFGWLLLKSLNILDKLEHLSREDLLEISRPFLAIMEVPP-EIMPTVIDEYLDNGSDQSA 404
            :|.|.||.....|:.|:     .:.:||::    |.:|...::.. .:...||::|       :|
  Fly   673 MGATAHEAHTEKLRELH-----ANWTREEV----RAYLENSQIGALGLTDEVIEKY-------NA 721

Mouse   405 TRYA-FQELLGDISFIIPTLNFSKYLRDAGCPVFLYEFQHTPSSFA-----------KFKPAWVK 457
            :.|| ...::.||..:.|.|..::  :....|.::......|...|           :::|..|:
  Fly   722 SSYASLVSIISDIRSVCPLLTNAR--QQPSVPFYVVTQGEGPDQLATVDADVQAILGRYEPHTVE 784

Mouse   458 ---------------ADHASENSFV 467
                           ..|.:..|||
  Fly   785 QRRFVSAMQQLFYYYVSHGTVQSFV 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ces3b	NP_653094.2	COesterase	36..547	CDD:278561	127/510 (25%)
		Aes	75..>245	CDD:223730	61/183 (33%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571
Nrt	NP_001189121.1	Abhydrolase	362..832	CDD:304388	123/494 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910