Protein Alignment Ces3b and Gli

DIOPT Version :9

• Sequence 1: NP_653094.2
• Gene: Ces3b / 13909
• MGIID: 3644960
• Length: 571
• Species: Mus musculus
• Sequence 2: NP_476602.1
• Gene: Gli / 34927
• FlyBaseID: FBgn0001987
• Length: 956
• Species: Drosophila melanogaster
• Alignment Length: 605
• Identity: 180/605 - (29%)
• Similarity: 261/605 - (43%)
• Gaps: 126/605 - (20%)

Mouse    39 VDTPLGRVRGRQVGVKD--------------TDRMV---NVFLGIPFAQAPVGPLRFSAPLPPQP 86
            |.|..|:|:|.:|.:.|              .||::   :||||||:|..|....||..|...:.
  Fly   137 VTTNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHRG 201

Mouse    87 WEGVRDASINPPMCLQDVEKMINSRFGLNEKIKIFPISEDCLTLNIYSP-TEITAGDKRPVMVWI 150
            |:.::..... |.|.|.| :...:..|      |..:.||||.||:||| |......|.||||:|
  Fly   202 WQLLQAVDFG-PACPQPV-RYTGATKG------IMDMDEDCLYLNVYSPKTGAGVAQKYPVMVYI 258

Mouse   151 HGGSLLVGSSTSQDGSALAAYGDVVVVTVQYRLGIFGFLSTGDKHMPGNRGFLDVVAALRWVQGN 215
            |||..:.|:|....|..||::.||||||:.||||..|||||||::.|||.|.||...|||||..|
  Fly   259 HGGEFIRGASNLFQGHILASFYDVVVVTLNYRLGALGFLSTGDENSPGNYGILDQAMALRWVYDN 323

Mouse   216 IAPFGGDPNCVTIFGNSAGGMIVSSLFLSPISAGLFHRAISQSG--IVTTIMMEDMKPWPEAQN- 277
            |..|.||.|.:|:||..|||.....|.::|.:..:..|.|:|||  :....:::|..   .|||
  Fly   324 IEFFNGDRNSITLFGPGAGGASAGLLMVAPQTRNIVRRVIAQSGSALADWALIQDKY---RAQNT 385

Mouse   278 ---FANSVACGSASPAELVQCLLQKEGKDLIKQKNVNISYIVND--------------------- 318
               ....:.|...|..:||.||  :.|:...:..|...|..|..
  Fly   386 SRVLGQLLGCSIESSWKLVNCL--RTGRSFYELGNAEFSPQVGSFPWGPVLDHNFTLPGDDWYEG 448

Mouse   319 ------SFFPQRPEKLLADQQF-PTVPYLLGVTNHEFGWLLLKSLNI-----LD------KL-EH 364
                  .|..|.||.|:...:| ..:.|:.|||..|..:.:.::.::     ||      |: ||
  Fly   449 WREKDWRFLTQTPETLIRAGKFNRNIQYMTGVTTQEAAFFVAQNESLSPYYELDGRFFDQKIREH 513

Mouse   365 LSRED-LLEISRPFLAIMEV----PPEIMPTVI-DEYLDNGSDQSATRYAFQELLGDISFIIPTL 423
            :.|.: .|..:..:.||..:    |.....|:| |:|::              :|.|:.:..|..
  Fly   514 VFRYNYTLNPNGVYEAIKYIYTFWPDPNNNTIIRDQYIN--------------MLSDLYYRAPVD 564

Mouse   424 NFSKYLRDAGCPVFLYEFQHTPSSFAKFKPAWVKADHASENSFVFGGPFLTDESSLLAFPEA--- 485
            ...|.:.:...||::|....|..  |...|.|.|..|..|..|:.|.||:..|    .||:.
  Fly   565 QMVKLMLEQKVPVYMYVLNTTVE--ALNLPQWRKYPHDIERYFLTGAPFMDTE----FFPKKEHL 623

Mouse   486 -----TEEEKQLSLTMMAQWSQFARTGNPNGKGLPPWPQLNQLEQ--------YLEIGLESRTGV 537
                 |:.::.:|...|..::.|||.|||.     |...|....|        ||.|.....:.:
  Fly   624 QRNMWTDNDRNMSHFFMQTYTNFARYGNPT-----PQQVLGMHFQRAYQGEIRYLNINTTYNSSI 683

Mouse   538 KL--KKGRLQFWTETLPRKI 555
            .|  ::....|||:.||..|
  Fly   684 LLNYRQTECAFWTQYLPTVI 703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ces3b	NP_653094.2	COesterase	36..547	CDD:278561	174/595 (29%)
		Aes	75..>245	CDD:223730	75/170 (44%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571
Gli	NP_476602.1	COesterase	134..695	CDD:278561	174/595 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810