Protein Alignment Ces1e and alpha-Est2

DIOPT Version :9

• Sequence 1: NP_598421.1
• Gene: Ces1e / 13897
• MGIID: 95432
• Length: 562
• Species: Mus musculus
• Sequence 2: NP_001262345.1
• Gene: alpha-Est2 / 40908
• FlyBaseID: FBgn0015570
• Length: 566
• Species: Drosophila melanogaster
• Alignment Length: 585
• Identity: 177/585 - (30%)
• Similarity: 254/585 - (43%)
• Gaps: 132/585 - (22%)

Mouse    14 FTAGAGHPSSPPMVDTVQGKVLGKYISLEGFTQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSSV 78
            :....||   ..::||..|:|.|.........:|...|.|:|:||||:|.|||..|||.|||..|
  Fly    25 YRLSTGH---TVILDTKYGQVRGLQRKTVYDKEPYFAFEGIPYAKPPVGDLRFRAPQPPEPWQGV 86

Mouse    79 KNATSYPPMCFQDPVTGQIVNDLLTNRKEKIPLQ---------FSEDCLYLNIYTPADLTKSDR- 133
            .|.|                    |||.:  |:|         .|||||:||:|..|  .||::
  Fly    87 LNCT--------------------TNRSK--PMQRNMLLGIVEGSEDCLHLNVYVKA--LKSEKP 127

Mouse   134 LPVMVWIHGGGLVLGGAS----TYDGLVLSTHENVVVVVIQYRLGIWGFFSTGDE--HSRGNWGH 192
            |||:|||:|||...|.||    :.|..:   .:.||.|.|.|||...||.|..|.  ...||.|.
  Fly   128 LPVIVWIYGGGFQKGEASRDIYSPDYFM---KKPVVFVAINYRLAALGFLSLKDPKLDVPGNAGL 189

Mouse   193 LDQVAALHWVQDNIAKFGGDPGSVTIFGESAGGESVSVLVLSPLAKNLFQRAISESGVALTAGLV 257
            .|||.||.|:..|||.|.|||.::|:.|||||..||.|::.:...:.||.:||.:||.||:. .|
  Fly   190 KDQVMALRWISQNIAHFNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSE-WV 253

Mouse   258 KKNTRPLAEKIAVISGCKNTTSAAMV------HCLRQ--KTEEELLGTTLKLNLFKLDLHGDSRQ 314
            :......|.::|...|.|.....|.|      .|.||  ..:::::... ::..|.|...|
  Fly   254 ESPDNNWAFRLAQNLGYKGDEKDADVLSFLSKVCARQIAAIDQDVINLD-EVRSFLLFAFG---- 313

Mouse   315 SHPFV-PTVLDGVLLPKMPEEILAEKNFNTVPYIVGINKQE--FG--------WILPTMMNYPPS 368
              |.: |...|..::||..:::|:|...|.:|.|||.|..|  |.        |.|....|..|.
  Fly   314 --PVIEPYETDHCVVPKRHKDLLSEAWGNDIPVIVGGNSFEGLFSYQLVRKDPWALKNFHNILPR 376

Mouse   369 DVKLDQMTAMSLLKKSSFLLNLPEDAIAVAIEKYLRDKD-YTGRNKDQLLELIGDV-VFGVPSV- 430
            :|:     ..|.|:....|:.              |.|. |......:.:|:...: :|....:
  Fly   377 EVR-----ETSSLEGQDLLVR--------------RLKQLYFNNEMQESMEMFEALNIFSHRQIW 422

Mouse   431 ------IVSRGHRDAGAPTYMYEFQY-SPSFSSEMKPDTVVGD------HGDEI----YSVFGAP 478
                  |::|.......|||:|.|.: ||.|:...:  .|.||      |.||:    |::..:.
  Fly   423 HDTHRFILARQSYAPKTPTYLYRFDFDSPHFNQFRR--LVCGDRIRGVAHADELSYLFYNIIASK 485

Mouse   479 ILRGGTSEEEINLSKMMMKFWANFARNGNPNGQGLPHWPEYDQKEGYLQIGATTQQAQKLKEKEV 543
            :   ..|..|....:.|:..|.:||.:||||      .||         :|:...:|.:|||..|
  Fly   486 L---DKSSMEYKTIERMVGMWTSFASSGNPN------CPE---------LGSAKWEAVQLKENAV 532

Mouse   544  543
              Fly   533  532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ces1e	NP_598421.1	COesterase	25..546	CDD:278561	175/574 (30%)
		Aes	44..>242	CDD:223730	87/213 (41%)
		Prevents secretion from ER. /evidence=ECO:0000255	559..562
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	170/564 (30%)
		Aes	<117..>221	CDD:223730	48/108 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832943
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650