DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ces1c and Nrt

DIOPT Version :9

Sequence 1:	NP_031980.2	Gene:	Ces1c / 13884	MGIID:	95420	Length:	554	Species:	Mus musculus
Sequence 2:	NP_001189121.1	Gene:	Nrt / 39873	FlyBaseID:	FBgn0004108	Length:	846	Species:	Drosophila melanogaster

Alignment Length:	580	Identity:	142/580 - (24%)
Similarity:	232/580 - (40%)	Gaps:	157/580 - (27%)

- Green bases have known domain annotations that are detailed below.

Mouse    16 ILGHSLL--PPVVDTTQGKVLGKYI-------SLEGFEQPVA-VFLGVPFAKPPLGSLRFAPPQP 70
            :|.|..|  ||:.:       |:||       .:||.::..| .|.|:|:||||:..||:.|.:.
  Fly   344 VLTHETLTSPPLRE-------GRYIMAVTGCGPVEGVKEDGAFAFRGIPYAKPPVDRLRWKPAEL 401

Mouse    71 AEP----WSFVKNATSYPPMCSQDAGWAKILSDMFSTEKEILPLKISEDCLYLNIYSPADLTKSS 131
            .:.    |:......:...:|:|..|....:.|              ||||||::.:| .:..::
  Fly   402 IDDINMCWNDTLQTHNSSVVCTQRLGNGTTVGD--------------EDCLYLDVVTP-HVRYNN 451

Mouse   132 QLPVMVWIHGGGLVIGGASPYNGL-----ALSAHENVVVVTIQYRLGIWGLFS----TGDEHSP- 186
            .|||:|.|  |...:.|.||  |:     ..|...:|:.|...:|||::|..:    |.:.|.|
  Fly   452 PLPVVVLI--GAESLAGPSP--GILRPSARYSRSHDVIFVRPNFRLGVFGFLALDALTKEAHPPT 512

Mouse   187 -GNWAHLDQLAALRWVQDNIANFGGNPDSVTIFGESSGGISVSVLVLSPLGKDLFHRAISESGVV 250
             ||:|..|.:|.|.|::.||.:|||:|.|||:.|..:|...|::||.|...|.|:.||.:.||..
  Fly   513 SGNYALTDIIAVLNWIKLNIVHFGGDPQSVTLLGHRAGATLVTLLVNSQKVKGLYTRAWASSGSA 577

Mouse   251 I-----NTNVGKKNIQAVNEIIATLSQCNDTSSAAMVQCLRQKTESEL--------LEISGKLVQ 302
            |     .:..||:|    .:::||| :|.|      :||||:.:...|        |.....|.|
  Fly   578 ILPGKPLSESGKQN----EQLMATL-ECAD------IQCLREASSERLWAATPDTWLHFPVDLPQ 631

Mouse   303 ---YNISLS----TMIDGVVLPKAPEEILAEKSFNTVPYIVGFNKQEFGWIIPMMLQNLLPEGKM 360
               .|.|.|    .::||.|:.:.|.:....:..|..|.:|                    .|..
  Fly   632 PQEANASGSRHEWLVLDGDVVFEHPSDTWKREQANDKPVLV--------------------MGAT 676

Mouse   361 NEETASLLLRRFHSELN-------ISESMIPA------VIEQYLRGVDDPAKKSELILDMFGDIF 412
            ..|..:..||..|:...       :..|.|.|      |||:|      .|.....::.:..||.
  Fly   677 AHEAHTEKLRELHANWTREEVRAYLENSQIGALGLTDEVIEKY------NASSYASLVSIISDIR 735

Mouse   413 FGIPAVLLSRSLRDAGVSTYMYE-------------------FRYRPSFVSDKRPQTVEGDHGDE 458
            ...|  ||:.:.:...|..|:..                   .||.|..|..:|..:..    .:
  Fly   736 SVCP--LLTNARQQPSVPFYVVTQGEGPDQLATVDADVQAILGRYEPHTVEQRRFVSAM----QQ 794

Mouse   459 IFFVFGAPLLKEGASEEETNLSKMVMKFWANFARNGNPNGEGLP--HWPEYDEQEGYLQI 516
            :|:.:    :..|..:......:::     |..::..|..:.||  :|...|....|.::
  Fly   795 LFYYY----VSHGTVQSFVQNRRVI-----NVGQDAQPEEDYLPCNYWISKDIVPRYARV 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ces1c	NP_031980.2	Esterase_lipase	25..525	CDD:238191	137/569 (24%)
		Aes	<121..>234	CDD:223730	42/123 (34%)
		Prevents secretion from ER. /evidence=ECO:0000255	551..554
Nrt	NP_001189121.1	Abhydrolase	362..832	CDD:304388	131/540 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910