DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Erg and Ets65A

DIOPT Version :9

Sequence 1:	NP_598420.1	Gene:	Erg / 13876	MGIID:	95415	Length:	486	Species:	Mus musculus
Sequence 2:	NP_001303373.1	Gene:	Ets65A / 38700	FlyBaseID:	FBgn0005658	Length:	728	Species:	Drosophila melanogaster

Alignment Length:	549	Identity:	193/549 - (35%)
Similarity:	253/549 - (46%)	Gaps:	150/549 - (27%)

- Green bases have known domain annotations that are detailed below.

Mouse     6 PDPAAHIKE----ALSVVSED-------QSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVP 59
            |...|.:|.    ||...|.:       ||.||....:...||..: ...||.:|.:|..|....
  Fly    19 PPTLAQVKTEECLALGQCSPEWTSYRFHQSTFEQLKQSVEKAKAAL-QDRSSFFGASSAFSDIYS 82

Mouse    60 QQDWLSQAPARVTIKMECNPSQVNGSRNSPDECSVNKGGKMVGSP--DTVGMSYGSYME------ 116
            .|        |:|..::..|.|           |.|.||..:|.|  ..||:.....:.
  Fly    83 SQ--------RLTDSLDTLPVQ-----------SGNGGGNCLGLPHNPNVGVGVAGVLNYNAVSS 128

Mouse   117 -------------EKH----VPPPN-----------MTTNERRV---------IVPADPTLW--S 142
                         ::|    :.||:           :|::..:|         ..||.|:|.  |
  Fly   129 STAGVLSSSGNGVQRHRLDTLQPPSGCSPAVTQHGVITSSAGQVTSGTLDAVSAAPALPSLTASS 193

Mouse   143 TDHVRQWLEWAVK-EYGLLDVDVLLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETP 206
            :.||    |..|: :...||              |..|.                ||    ...|
  Fly   194 SSHV----EHKVRADKSTLD--------------CATTS----------------SH----AAAP 220

Mouse   207 LPHLTSDDVDKALQNSPRLMHARNTGGAAFIF--PNTSVYPEATQRITTRPDLPYEPPRRSAWTG 269
            ....::.|..:...:..:..:...|||.|...  ..:::|..                .:|:|..
  Fly   221 SSSSSASDHQQGRISGSKSSNTSGTGGGASASGGGGSALYSS----------------YKSSWGS 269

Mouse   270 HSHLTPQSKAAQPSPSAVPKTEDQRPQL---DPYQILGPTSSRLANPGSGQIQLWQFLLELLSDS 331
            ||....|..    |.:|:....|...||   ||||:.||||||||:.||||||||||||||||||
  Fly   270 HSSTQSQGY----SSNALGIKHDPHSQLRQPDPYQMFGPTSSRLASSGSGQIQLWQFLLELLSDS 330

Mouse   332 SNSNCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYK 396
            :|::||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||
  Fly   331 NNASCITWEGTNGEFKLTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYK 395

Mouse   397 FDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVSPHPPALPVTSSSFFASPNPY-- 459
            |||.|:|.|.||...:.: |||.||| :|..||...:..:|:||| ..:..:|:|.|.|...:
  Fly   396 FDFQGLAAATQPAASDPT-YKYQSDL-FMTPYHHSAKLSSFMSPH-HGMTSSSASIFPSAASWGN 457

Mouse   460 WNSPTGGIY-PN--TRLPASHMPSHLGTY 485
            |.||...:| |:  :.:..||:..||.:|
  Fly   458 WGSPATNLYQPHSMSHVTPSHVAPHLSSY 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Erg	NP_598420.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..62		5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	79..99		5/19 (26%)
		SAM_superfamily	122..205	CDD:387673	19/105 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..311		20/64 (31%)
		ETS	317..400	CDD:197710	78/82 (95%)
Ets65A	NP_001303373.1	ETS	316..401	CDD:197710	79/84 (94%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1113327at2759
OrthoFinder	1	1.000	-	-		FOG0003089
OrthoInspector	1	1.000	-	-		otm43545
orthoMCL	1	0.900	-	-		OOG6_105242
Panther	1	1.100	-	-	O	PTHR11849
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3711
SonicParanoid	1	1.000	-	-		X1794
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.950