Protein Alignment CREBBP and BDF2

DIOPT Version :10

• Sequence 1: NP_004371.2
• Gene: CREBBP / 1387
• HGNCID: 2348
• Length: 2442
• Species: Homo sapiens
• Sequence 2: NP_010213.1
• Gene: BDF2 / 851488
• SGDID: S000002228
• Length: 638
• Species: Saccharomyces cerevisiae
• Alignment Length: 466
• Identity: 107/466 - (22%)
• Similarity: 173/466 - (37%)
• Gaps: 105/466 - (22%)

Human   774 NMMGAHTNNMMAQAPAQSQFLPQNQFPSSSGAMS------VGMGQPPAQTGVSQGQVPGAALPNP 832
            ||...|.::.:..|| ||.........|||.:.|      ||:|.       ..|.|...::.:
Yeast     5 NMDTRHAHSALLAAP-QSATANSRSSNSSSESSSNKNNINVGVGD-------DSGNVSAVSIDD- 60

Human   833 LNMLGPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPT-QPSTPVS-SS 895
                ||....:         .|         .|..........|:|....::.. |..:|:| |:
Yeast    61 ----GPHFRDI---------FH---------YGHEENYKLASSGITNLNSSSHAHQTLSPISISN 103

Human   896 GQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQTPVQPPSV-ATPQSSQQQPTPVHAQPPGT 959
            ..||...| ..|...:.::.|.::|..:|:..|..|:.....|: ||.:....:|    ...|..
Yeast   104 ASTPESFP-EHPLGLERETEPALEAEMEAEELPPHQSKYLLSSIKATKRLKDARP----FLKPVD 163

Human   960 PLSQAAASIDNRVPTPSSVASAETNSQQ-----------------------PGPDVPVLEMKTET 1001
            |::.......|.|.||..::..||..|.                       .||:..:..|....
Yeast   164 PIALNIPHYFNYVQTPMDLSLIETKLQGNVYHSVEQVTSDFKTMVDNCLNFNGPESSISSMAKRI 228

Human  1002 QAEDTEPDPGESKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKP-EVKVEVKEEEES 1065
            |          ...|.:...|...:..||.:| :|....:|:|.|:    .| .::..|....::
Yeast   229 Q----------KYFEKKLSAMPPRVLPASALK-KTSRNRKKNEDMD----SPLVIRRSVSTTNDN 278

Human  1066 SSNGTASQSTSPSQPRKKIFKPE--------ELRQALMPTLEALYR-------------QDPESL 1109
            .......:..|..:|::.|..|:        |..:....||:..:|             ....:.
Yeast   279 IGESGNREGVSGGRPKRTIHPPKSKDLFDIYENSKPKSKTLQKKFRTCLKILKVLMSKKNSDINF 343

Human  1110 PFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRV 1174
            ||.|||||..|.:|:|||:|||||||.||...|...:|:...|:|||:.|:|.|.:.:|.:.:.|
Yeast   344 PFLQPVDPIALNLPNYFDVVKNPMDLGTISNNLMNWKYKTIDQFVDDLNLVFYNCFQFNPEGNEV 408

Human  1175 YKFCSKLAEVF 1185
            :....||.|:|
Yeast   409 HSMGKKLKELF 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CREBBP	NP_004371.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..41
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	74..179
		Interaction with SRCAP. /evidence=ECO:0000269|PubMed:10347196	227..410
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	266..290
		zf-TAZ	363..430	CDD:460457
		KIX	587..667	CDD:366953
		PHA03247	<683..1025	CDD:223021	54/282 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	794..1083		58/321 (18%)
		Bromo_cbp_like	1087..1194	CDD:99927	41/120 (34%)
		Interaction with histone. /evidence=ECO:0000269|PubMed:24361270	1124..1170		22/45 (49%)
		Interaction with ASF1A. /evidence=ECO:0000269|PubMed:24616510	1162..1180		3/17 (18%)
		RING_CBP-p300	1206..1278	CDD:276805
		PHD_CBP_p300	1280..1311	CDD:277032
		HAT_KAT11	1342..1649	CDD:400497
		Interaction with histone. /evidence=ECO:0000250|UniProtKB:Q09472	1433..1435
		Interaction with TRERF1. /evidence=ECO:0000269|PubMed:11349124	1460..1891
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1556..1615
		ZZ_CBP	1705..1745	CDD:239077
		zf-TAZ	1772..1840	CDD:460457
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1874..1959
		Med15	1960..>2423	CDD:312941
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1977..2028
		Creb_binding	2013..2114	CDD:462659
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2112..2263
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2294..2433
BDF2	NP_010213.1	COG5076	55..378	CDD:227408	77/365 (21%)
		Bromodomain	<344..419	CDD:445827	35/74 (47%)
		Lebercilin	<472..>537	CDD:464776
		BET	521..576	CDD:435704