Protein Alignment CREBBP and BDF1

DIOPT Version :10

• Sequence 1: NP_004371.2
• Gene: CREBBP / 1387
• HGNCID: 2348
• Length: 2442
• Species: Homo sapiens
• Sequence 2: NP_013503.1
• Gene: BDF1 / 851115
• SGDID: S000004391
• Length: 686
• Species: Saccharomyces cerevisiae
• Alignment Length: 786
• Identity: 154/786 - (19%)
• Similarity: 253/786 - (32%)
• Gaps: 312/786 - (39%)

Human   926 VTPQPQTPVQPPSVATPQSSQQQP--TPVH---AQPPGTPLSQAAASI-DNRVPTPSSVASAETN 984
            |:...:.|:.....:...:.::.|  ..:|   |:..|..|:.:.|.: :|.:...:..|:.|..
Yeast    22 VSSNLKRPIDQGDPSNGLAEEENPANNQLHLKKARLDGDALTSSPAGLAENGIEGATLAANGENG 86

Human   985 SQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVD 1049
            ....|           :.|||      |.:|..:    ||..||..|  |:.|           :
Yeast    87 YNATG-----------SGAED------EQQGLKK----EEGGQGTKQ--EDLD-----------E 117

Human  1050 EKKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQP 1114
            ..|.|:.:||.:|...:.......:..|..|..|    .:.:.||: .::|:.|. .::.||.||
Yeast   118 NSKQELPMEVPKEPAPAPPPEPDMNNLPQNPIPK----HQQKHALL-AIKAVKRL-KDARPFLQP 176

Human  1115 VDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCS 1179
            |||..|.||.||:.:|.|||||||:|||:.|.|:.|.|..:|..||.||:..:|...:.:.:...
Yeast   177 VDPVKLDIPFYFNYIKRPMDLSTIERKLNVGAYEVPEQITEDFNLMVNNSIKFNGPNAGISQMAR 241

Human  1180 KLAEVFE--------QEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHF 1236
            .:...||        ::..||:..     ||:               .:...||.....:.:.|
Yeast   242 NIQASFEKHMLNMPAKDAPPVIAK-----GRR---------------SSAQEDAPIVIRRAQTH- 285

Human  1237 CEKCFTEIQGENVTLGDDPSQPQTTI----SKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLH 1297
                              ..:|:.||    |||.:
Yeast   286 ------------------NGRPKRTIHPPKSKDIY------------------------------ 302

Human  1298 YDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVV 1362
                                |.:..|..:||||          :..||.:        .|...::
Yeast   303 --------------------PYESKKPKSKRLQ----------QAMKFCQ--------SVLKELM 329

Human  1363 ASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTR 1427
            |..                  ..|.::|:       .|.:|.|.:            :.|.
Yeast   330 AKK------------------HASYNYPF-------LEPVDPVSM------------NLPT---- 353

Human  1428 RVYISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKK---LGYVTGHI--WACPPSEGDD------ 1481
                                         |.:|||:   ||.:...:  |.....|..:
Yeast   354 -----------------------------YFDYVKEPMDLGTIAKKLNDWQYQTMEDFERDVRLV 389

Human  1482 ----YIFHCHPPDQKIPK--PKRLQEWYKKMLDKAFAER-IIHDYKDIFKQATEDRLTSAK---- 1535
                |.|:   ||..|..  ..||:|    :.:..:|:| .:.||     .:.||..|...
Yeast   390 FKNCYTFN---PDGTIVNMMGHRLEE----VFNSKWADRPNLDDY-----DSDEDSRTQGDYDDY 442

Human  1536 ELPYFEGDFWPNV--------LEESIKELEQEEEERKKEESTAASETTEGSQGDSKNAKKKNNKK 1592
            |..|.|.|....:        |||.:..::.|.::.||:|.....:....::|..|..|:...:.
Yeast   443 ESEYSESDIDETIITNPAIQYLEEQLARMKVELQQLKKQELEKIRKERRLARGSKKRGKRSKGRS 507

Human  1593 TNKNKSSISRANKK----------------------------------KPSMPNVSNDLSQKL-Y 1622
            .:||.||..|.:||                                  |.||||:|.|...:| .
Yeast   508 GSKNASSKGRRDKKNKLKTVVTYDMKRIITERINDLPTSKLERAIDIIKKSMPNISEDDEVELDL 572

Human  1623 ATMEKH 1628
            .|::.|
Yeast   573 DTLDNH 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CREBBP	NP_004371.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..41
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	74..179
		Interaction with SRCAP. /evidence=ECO:0000269|PubMed:10347196	227..410
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	266..290
		zf-TAZ	363..430	CDD:460457
		KIX	587..667	CDD:366953
		PHA03247	<683..1025	CDD:223021	18/104 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	794..1083		31/162 (19%)
		Bromo_cbp_like	1087..1194	CDD:99927	41/114 (36%)
		Interaction with histone. /evidence=ECO:0000269|PubMed:24361270	1124..1170		23/45 (51%)
		Interaction with ASF1A. /evidence=ECO:0000269|PubMed:24616510	1162..1180		3/17 (18%)
		RING_CBP-p300	1206..1278	CDD:276805	9/75 (12%)
		PHD_CBP_p300	1280..1311	CDD:277032	0/30 (0%)
		HAT_KAT11	1342..1649	CDD:400497	64/352 (18%)
		Interaction with histone. /evidence=ECO:0000250|UniProtKB:Q09472	1433..1435		0/1 (0%)
		Interaction with TRERF1. /evidence=ECO:0000269|PubMed:11349124	1460..1891		53/234 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1556..1615		19/92 (21%)
		ZZ_CBP	1705..1745	CDD:239077
		zf-TAZ	1772..1840	CDD:460457
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1874..1959
		Med15	1960..>2423	CDD:312941
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1977..2028
		Creb_binding	2013..2114	CDD:462659
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2112..2263
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2294..2433
BDF1	NP_013503.1	COG5076	1..373	CDD:227408	106/567 (19%)
		Bromodomain	<339..417	CDD:445827	21/136 (15%)
		PTZ00108	<386..647	CDD:240271	46/205 (22%)
		BET	527..589	CDD:435704	10/52 (19%)