Protein Alignment CREBBP and crebbpa

DIOPT Version :10

• Sequence 1: NP_004371.2
• Gene: CREBBP / 1387
• HGNCID: 2348
• Length: 2442
• Species: Homo sapiens
• Sequence 2: XP_005161826.1
• Gene: crebbpa / 566841
• ZFINID: ZDB-GENE-050208-439
• Length: 2350
• Species: Danio rerio
• Alignment Length: 2555
• Identity: 1640/2555 - (64%)
• Similarity: 1828/2555 - (71%)
• Gaps: 318/2555 - (12%)

Human     1 MAENLLD-GPPNPKRAKLSSPGFSANDSTDFGSLF--DLENDLPDELIPNGGELGLLN------- 55
            ||||:|| ||||.|||||::|   |.|:.:.|||.  ||||||||||||| |:|||::
Zfish     1 MAENVLDVGPPNAKRAKLTAP---APDAPELGSLSWDDLENDLPDELIPN-GDLGLMSLPSNGGA 61

Human    56 -----SGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANMASL 115
                 .|.:|||||:||||||||||.||.:.:|       :.||...|:|.|            |
Zfish    62 AGTGAHGPMVPDAAAKHKQLSELLRPGSSAGMN-------SVSPQPGGIGPQ------------L 107

Human   116 SAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNAN 180
            ..:|||||.||..|.||                     |.||..|    :|.|.....| .....
Zfish   108 GGLGKSPLGQGSPSHPS---------------------QTQKPGG----TPGTQGNNAG-SAGMG 146

Human   181 FNQTHPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASS--------- 236
            |||   |:|  |||....|..:|| .||:||:||..|||||....|...|||.|||
Zfish   147 FNQ---GML--NSGMMGQNAGAQG-GQVINGALGTVGRGRGVQGMYQGAAMQVASSVGAGGGVGA 205

Human   237 -------SVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSPFGQPFSQAGGQPMGATGVN 294
                   |||||||||.:.||    |:|..|    ||||:.|..|||||  .|||||.:|....|
Zfish   206 AAPGGAGSVLAETLTQGAQQM----GINAQQ----AKMGMAGGNSPFGQ--YQAGGQQLGTNAQN 260

Human   295 PQLASKQSMVNSLPTFPTDIKNTSVTNVPNM-SQMQTSVGIVPTQAIATGPTADPEKRKLIQQQL 358
                 |.::.||||.||||:|..:||:|||| .|.|.|||:|..|.::|||||||||||||||||
Zfish   261 -----KGALPNSLPPFPTDLKGATVTSVPNMPQQQQVSVGMVAGQGVSTGPTADPEKRKLIQQQL 320

Human   359 VLLLHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCT 423
            |||||||||||||||||:||||:|||||||||||||||||||||:||||||||||||||||||||
Zfish   321 VLLLHAHKCQRREQANGDVRACALPHCRTMKNVLNHMTHCQAGKSCQVAHCASSRQIISHWKNCT 385

Human   424 RHDCPVCLPLKNASD---KRNQQTILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQRAY 485
            ||||||||||||||:   |.|||.:|..|.:.:|..|||||||||.|.:|.:..|||||||:|||
Zfish   386 RHDCPVCLPLKNASENANKHNQQPMLSPPNASLQTPIGSVGTGQQTAPALPSSTPIDPSSMRRAY 450

Human   486 AALGLPYMNQPQTQ----LQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNIPAGGITTDQQPPNLI 546
            |||||||.||..||    .|.|.|||..||....|.||::|.||...:| |.|..|::|  ..|:
Zfish   451 AALGLPYSNQNPTQTQSPTQTQGPGQTTAQTPHQQPMRSINALGGGQLN-PIGVPTSEQ--AKLL 512

Human   547 SESALPTSLGATNPLMNDGSNSGNIGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQA 611
            .:..:|::|  .||:|.|||..||   ||.:|||||.|:|||||.||||||||||:|||||||||
Zfish   513 PDGTMPSTL--NNPVMPDGSTVGN---LSNLPTAAPLSATGVRKAWHEHVTQDLRNHLVHKLVQA 572

Human   612 IFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQ 676
            ||||||||||||||||||||||:||||||||||||||||||.||||||||||||||||||||.||
Zfish   573 IFPTPDPAALKDRRMENLVAYARKVEGDMYESANSRDEYYHFLAEKIYKIQKELEEKRRSRLQKQ 637

Human   677 GILGNQPALPAPGAQPPVI--PQAQPVRPPNGPLSLP------VNRMQVSQGMNSFNPMSLGNVQ 733
            .|  ||.::.|.|.||..:  |.....||.|||:.:|      :||||||||||.|:.||  ||.
Zfish   638 II--NQTSMTATGQQPSALNQPNVMGPRPQNGPVPMPNVPNQILNRMQVSQGMNPFSAMS--NVP 698

Human   734 LPQAPMGPRAASPMNHSVQMNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQ 798
            :.|||||.|||||:||  |..:|..||.|.:||:|:.....|:|||..||:.|.|.|:||:.|..
Zfish   699 MSQAPMGTRAASPINH--QQINMNQVPTMNMSPTRIAPTQGMLGAHGGNMVTQTPNQTQFMTQPP 761

Human   799 FPSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHPTPPPASTA 863
            ||:::..|:|.||||.:||.||| |.|.|.|  |||.|||....|.||...|:||..||||.:||
Zfish   762 FPATTNTMNVNMGQPNSQTPVSQ-QQPNANL--PLNALGPLGPALGCPTPPQAPLRATPPPNATA 823

Human   864 AGMPSLQHTTPPGMTPPQPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTP 928
            |...:|            ||| .|||        ||||.|                    ||.||
Zfish   824 ASTTNL------------PAA-LQPS--------TPTPAP--------------------AQATP 847

Human   929 QPQTPVQPPSVATPQSSQQQPTPVHAQP-PGTPLSQAAASIDNRVPTPSSVASAETNSQQPGPDV 992
                         |....|...|:..|. ||||..      :||||||:|.||.|.:||...|||
Zfish   848 -------------PHMQTQAELPIPGQQHPGTPTG------ENRVPTPASAASTELHSQHAVPDV 893

Human   993 PVLEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKV 1057
            |..:.|||.|..|.     ..|.||.:| .|||.......|||.:.:|.|.||||.::||.::|.
Zfish   894 PPNDTKTEEQDYDM-----AVKTEPSTE-TEEDTGSLLVKKEEQEGSEAKQEPMETEDKKTDLKT 952

Human  1058 EVKEEEESSSNGTASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGI 1122
            |.|||:||.:||||  |:||||.|:|||||||||||||||||:|||||||||||||||||.||||
Zfish   953 ETKEEDESKTNGTA--SSSPSQSRRKIFKPEELRQALMPTLESLYRQDPESLPFRQPVDPILLGI 1015

Human  1123 PDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQ 1187
            ||||||||||:|||||||||||||||||||||||||||||||||||||||||||:||||||||||
Zfish  1016 PDYFDIVKNPIDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKYCSKLAEVFEQ 1080

Human  1188 EIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLG 1252
            |||||||.|||||||||||||||||||||||||||||..|||||||||||||||.||||::||||
Zfish  1081 EIDPVMQGLGYCCGRKYEFSPQTLCCYGKQLCTIPRDGTYYSYQNRYHFCEKCFNEIQGDSVTLG 1145

Human  1253 DDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGR 1317
            |||:||||.|||||||:||||||||||||:||:|||||||||||||::||||||:|||||||:.:
Zfish  1146 DDPAQPQTMISKDQFERKKNDTLDPEPFVECKDCGRKMHQICVLHYEVIWPSGFICDNCLKKSAK 1210

Human  1318 PRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDS 1382
            .||||||:|||||:||||.::||||||:|:|||||||||||||||||||||||||||||::|||:
Zfish  1211 SRKENKFTAKRLQSTRLGTYIEDRVNKYLKRQNHPEAGEVFVRVVASSDKTVEVKPGMKAKFVDT 1275

Human  1383 GEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRT 1447
            |||.|:||||||||||||||||||||||||||||||||||.|||||||||||||||||:||.|||
Zfish  1276 GEMMEAFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPFPNTRRVYISYLDSIHFFKPRMLRT 1340

Human  1448 AVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFA 1512
            |||||||||||||||||||||.|||||||||||||||||||.||||||||||||||:||||||||
Zfish  1341 AVYHEILIGYLEYVKKLGYVTAHIWACPPSEGDDYIFHCHPADQKIPKPKRLQEWYRKMLDKAFA 1405

Human  1513 ERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAASETTEG 1577
            |||:||||||||||||||||||.||||||||||||||||||||||||||||||||:|||.||.||
Zfish  1406 ERILHDYKDIFKQATEDRLTSANELPYFEGDFWPNVLEESIKELEQEEEERKKEENTAACETPEG 1470

Human  1578 SQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPV 1642
            :.||||||||||||||||||||:||||||||.||||:||||||||||||||||||||||||:||:
Zfish  1471 TPGDSKNAKKKNNKKTNKNKSSLSRANKKKPGMPNVANDLSQKLYATMEKHKEVFFVIHLHSGPI 1535

Human  1643 INTLPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTC 1707
            :|:|.||:|.||||:||||||||||||||||||||||||||.||||:|||||||.||||||||||
Zfish  1536 VNSLLPILDSDPLLNCDLMDGRDAFLTLARDKHWEFSSLRRCKWSTMCMLVELHNQGQDRFVYTC 1600

Human  1708 NECKHHVETRWHCTVCEDYDLCINCYNTKSHAHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSI 1772
            ||||||||||||||||||:||||||||.|.|.|:||||||||||:.|||....||||||||||||
Zfish  1601 NECKHHVETRWHCTVCEDFDLCINCYNAKGHEHQMVKWGLGLDDDSSSQSGEASKSPQESRRLSI 1665

Human  1773 QRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENK 1837
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish  1666 QRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENK 1730

Human  1838 CPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPS-PTSAPPGTPT--QQPST 1899
            |||||||||||||||||:||||||||:||||||||..|.:| ||||| |.|..|.|||  |||:|
Zfish  1731 CPVPFCLNIKHKLRQQQLQHRLQQAQMMRRRMATMQGRAMP-QSLPSPPASTAPSTPTSHQQPNT 1794

Human  1900 PQTPQP-PAQP-QPSPVSMSPAGFPSVART-QPPTTVSTGKP--------TSQVPAPPPP----- 1948
            |||||| |.|| .|:.|.|||. :|:..|. ||....|.|||        ..|.|.|.||
Zfish  1795 PQTPQPLPNQPTTPNAVVMSPT-YPNTPRNGQPLPQASQGKPGPQASPLHQQQSPLPQPPQQQPP 1858

Human  1949 --------AQPPPAAVEAARQIEREAQQQQHLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRP 2005
                    .||||.||:.||.||..||.||: ||:.: |.:|........||:...|:.|..||.
Zfish  1859 PQQPPQQQQQPPPMAVKMARHIEMVAQAQQN-YRMTM-NGLPMNHQQPRMPGAMQPPMQLVGPRG 1921

Human  2006 NQVSGPV---------MPSMPPGQWQQAPLPQQQPMPGLP--RPVISMQAQAAVAGPRM------ 2053
            .||..|:         .||||..|.|.|....|.|...||  ||.:..|    ||.|||
Zfish  1922 QQVMQPMPQGQWPGGAQPSMPAAQQQVAQQTPQGPQSTLPIQRPAMPQQ----VAQPRMMVPTQG 1982

Human  2054 PSVQPPR---SISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGM 2115
            |..|.|:   .|:|:|||||||||||||||||||||||||||||||||||||||||||.|:||..
Zfish  1983 PRPQAPQRAAGIAPNALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYHASQPQQ 2047

Human  2116 QPQPGLQSQPGMQPQPGMH-QQPSLQNLNAMQAGVPRPGVPPQQ-------QAMGGLNPQGQALN 2172
            |           |||.|:| .||::||:.|||| |||||:.|||       |.|..|.||||
Zfish  2048 Q-----------QPQQGIHAAQPAMQNMAAMQA-VPRPGMAPQQQQQQPTPQGMAALGPQGQ--- 2097

Human  2173 IMNPGHNPNMASMNPQYREMLRRQLLQQQQQQQQQQQQQQQQQQGSAGMAGGM-AGHGQFQQPQG 2236
            :|||.     .:.|||.:||.|||||:.||||||||||            ||| ..||||.|.||
Zfish  2098 LMNPA-----PANNPQLQEMYRRQLLRHQQQQQQQQQQ------------GGMPQAHGQFPQAQG 2145

Human  2237 PGGYPPAMQQQQRMQQHLPLQGSSMGQMAAQMGQLGQMGQPGLGADSTPNIQQALQQRILQQQQM 2301
            .......::.|   ||.|.:||:     ...||||..|.|  :..|.|||:.......:|||||:
Zfish  2146 TATNYTQLRMQ---QQQLAMQGT-----GGPMGQLPPMAQ--MAMDGTPNLLHQRNNLLLQQQQL 2200

Human  2302 KQQ-------IGSPGQPNPMSPQQHMLSGQPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQ-- 2357
            .||       :||..||:|||||.|:||||||.:|||||.:|.:|||||.||.|||||||.||
Zfish  2201 PQQQVVLKPPMGSQAQPSPMSPQTHLLSGQPQGAHLPGQPMANALSNQVCSPGPVQSPRPPSQQP 2265

Human  2358 PPHSSPSPRIQPQPSPHHVSPQTGSPHPGLAVTMASSIDQGHLGNPEQSAMLPQLNTPSRSALSS 2422
            ||||||||.:||||||.||...||||||||...|..|:||||||.|||||||||||||:|..|.|
Zfish  2266 PPHSSPSPHVQPQPSPQHVPSHTGSPHPGLTTPMPGSMDQGHLGTPEQSAMLPQLNTPNRGGLPS 2330

Human  2423 ELSLVGDTTGDTLEKFVEGL 2442
            :|::||||||||||||||||
Zfish  2331 DLNMVGDTTGDTLEKFVEGL 2350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CREBBP	NP_004371.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..41		26/42 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	74..179		28/104 (27%)
		Interaction with SRCAP. /evidence=ECO:0000269|PubMed:10347196	227..410		124/199 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	266..290		14/23 (61%)
		zf-TAZ	363..430	CDD:460457	63/66 (95%)
		KIX	587..667	CDD:366953	75/79 (95%)
		PHA03247	<683..1025	CDD:223021	144/350 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	794..1083		117/289 (40%)
		Bromo_cbp_like	1087..1194	CDD:99927	102/106 (96%)
		Interaction with histone. /evidence=ECO:0000269|PubMed:24361270	1124..1170		44/45 (98%)
		Interaction with ASF1A. /evidence=ECO:0000269|PubMed:24616510	1162..1180		16/17 (94%)
		RING_CBP-p300	1206..1278	CDD:276805	63/71 (89%)
		PHD_CBP_p300	1280..1311	CDD:277032	25/30 (83%)
		HAT_KAT11	1342..1649	CDD:400497	278/306 (91%)
		Interaction with histone. /evidence=ECO:0000250|UniProtKB:Q09472	1433..1435		1/1 (100%)
		Interaction with TRERF1. /evidence=ECO:0000269|PubMed:11349124	1460..1891		385/431 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1556..1615		51/58 (88%)
		ZZ_CBP	1705..1745	CDD:239077	34/39 (87%)
		zf-TAZ	1772..1840	CDD:460457	67/67 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1874..1959		50/111 (45%)
		Med15	1960..>2423	CDD:312941	260/500 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1977..2028		18/59 (31%)
		Creb_binding	2013..2114	CDD:462659	69/111 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2112..2263		70/159 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2294..2433		99/147 (67%)
crebbpa	XP_005161826.1	Med15	81..>301	CDD:312941	114/285 (40%)
		zf-TAZ	325..392	CDD:460457	63/66 (95%)
		KIX	548..628	CDD:366953	75/79 (95%)
		Atrophin-1	714..>903	CDD:460830	100/253 (40%)
		Bromo_cbp_like	980..1087	CDD:99927	102/106 (96%)
		RING_CBP-p300	1099..1171	CDD:276805	63/71 (89%)
		PHD_CBP	1172..1206	CDD:277117	28/33 (85%)
		HAT_KAT11	1235..1542	CDD:413203	278/306 (91%)
		ZZ_CBP	1598..1638	CDD:239077	34/39 (87%)
		zf-TAZ	1665..1733	CDD:460457	67/67 (100%)
		Atrophin-1	1768..>1988	CDD:460830	92/227 (41%)
		Med15	1892..>2333	CDD:312941	252/487 (52%)
		Creb_binding	1925..2043	CDD:462659	68/121 (56%)