|
Human 1 MAENLLDGPPNPKRAKLSSPGFSANDSTDFGSLFDLENDLPDELIPN------------------ 47
||:: ||.||. ||.|: |.||.. :.||.:|||||:.:
Fly 2 MADH-LDEPPQ-KRVKM--------DPTDIS--YFLEENLPDELVSSNSGWSDQLTGGAGGGNGG 54
Human 48 GGELGLLNSGNLVPD-AASKHKQLSE---LLRGGSGSSINPGIGNVSASSPV---QQGLGG---- 101
||..|:..:....|: ....:|..:: ...||.|..:|.|:|.|.....| ..|.||
Fly 55 GGASGVTTNPTSGPNPGGGPNKPAAQGPGSGTGGVGVGVNVGVGGVVGVGVVPSQMNGAGGGNGS 119
Human 102 --------------------------------QAQGQPNSANMASLSAMG-KSPLSQGDSS---- 129
|.|||..:..:..:..:| |||..|..:.
Fly 120 GTGGDDGSGNGSGAGNRISQMQHQQLQHLLQQQQQGQKGAMVVPGMQQLGSKSPNLQSPNQGGMQ 184
Human 130 ---------APSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTH 185
..|:|...::.......|...:|..||..:| :...|:..|.|:....|..:..
Fly 185 QVVGTQMGMVNSMPMSISNNGNNGMNAIPGMNTIAQGNLG---NMVLTNSVGGGMGGMVNHLKQQ 246
Human 186 P-----GLLNS------------------------NSGHSLINQASQGQ----------AQVMNG 211
| |::|| |.|..:.|....|: ..:|..
Fly 247 PGGGGGGMINSVSVPGGPGAGAGGVGAGGGGAVAANQGMHMQNGPMMGRMVGQQHMLRGPHLMGA 311
Human 212 SLGAAGRGRGAG-----MPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNT------------- 258
|.||.|.|.|.| |..|...|.....:....:|.....|..|..|.|.
Fly 312 SGGAGGPGNGPGGGGPRMQNPNMQMNFRPFAAQLNSLPYGVGQYGGPGGGNNPQQQQQQQQQQLL 376
Human 259 ----AQAGGMAKMGITGNTSPFGQ--PFSQAGGQPMGATGV----NPQ----LASKQS-MVNSLP 308
||.||:.. |:.....|.|. |.|..||...|..|. ||| ||.:|: .:...|
Fly 377 AQQMAQRGGVVP-GMPQGNRPVGTVVPMSTLGGDGSGPAGQLVSGNPQQQQMLAQQQTGAMGPRP 440
Human 309 TFPTDI--------KNTSVTNVPNMSQMQTSVGI--------------VPTQA--------IATG 343
..|..: :...........|.|..||| ||..| .::|
Fly 441 PQPNQLLGHPGQQQQQQQQPGTSQQQQQQQGVGIGGAGVVANAGTVAGVPAVAGGGAGGAVQSSG 505
Human 344 P------TADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGK 402
| ..|..||: |||||:||||||||.|||..|.....|::.:|:.||:||.||..|:..|
Fly 506 PGGANRDVPDDRKRQ-IQQQLMLLLHAHKCNRRENLNPNREVCNVNYCKAMKSVLAHMGTCKQSK 569
Human 403 ACQVAHCASSRQIISHWKNCTRHDCPVCLPLK-NASDKRNQQT--------ILGSPASGIQNTIG 458
.|.:.||||||||:.|:|.|....|.:|.|.: |.|..:|... |.|:|..|.....|
Fly 570 DCTMQHCASSRQILLHYKTCQNSGCVICYPFRQNHSVFQNANVPPGGGPAGIGGAPPGGGGAGGG 634
Human 459 SVGTG-------QQNATSLSNPNP--------------IDPS----------SMQRAYAALGLP- 491
:.|.| ||......|..| :.|. ..|.|..|.|.|
Fly 635 AAGAGGNLQQQQQQQQQQQQNQQPNLTGLVVDGKQGQQVAPGGGQNTAIVLPQQQGAGGAPGAPK 699
Human 492 -------YMNQPQTQLQPQV---------------------------------------PGQQPA 510
.:.|.|.|.|.|| .|.|||
Fly 700 TPADMVQQLTQQQQQQQQQVHQQQVQQQELRRFDGMSQQVVAGGMQQQQQQGLPPVIRIQGAQPA 764
Human 511 -----------------------------------------------------QPQTHQQMRTL- 521
|.|.|||.:..
Fly 765 VRVLGPGGPGGPSGPNVLPNDVNSLHQQQQQMLQQQQQQGQNRRRGGLATMVEQQQQHQQQQQQP 829
Human 522 NP--LGNN---PMNIPAGGI---------------TTDQQPPNLI-------------------- 546
|| ||.| |:::..||. ..|:|...:.
Fly 830 NPAQLGGNIPAPLSVNVGGFGNTNFGGAAAGGAVGANDKQQLKVAQVHPQSHGVGAGGASAGAGA 894
Human 547 --------SESALPT----SLGATNPLMN--------DGSNSGNIGTLSTIPTAAPPSSTGVRKG 591
|...:|. |..|.||..| .|.|.||.| ||... .|.
Fly 895 SGGQVAAGSSVLMPADTTGSGNAGNPNQNAGGVAGGAGGGNGGNTG---------PPGDN--EKD 948
Human 592 WHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAE 656
|.|.||.|||:|||||||||||||.||..::|:||.|||:||:|||.||||.|.||.||||||||
Fly 949 WRESVTADLRNHLVHKLVQAIFPTSDPTTMQDKRMHNLVSYAEKVEKDMYEMAKSRSEYYHLLAE 1013
Human 657 KIYKIQKELEEKR--RSRLHKQGILGNQ-PALPAPG------------AQPPVIPQAQPVRPPNG 706
||||||||||||| |...|:|.::..| .|.|..| |...|:||.|..:
Fly 1014 KIYKIQKELEEKRLKRKEQHQQMLMQQQGVANPVAGGAAGGAGSAAGVAGGVVLPQQQQQQ---- 1074
Human 707 PLSLPVNRMQVSQGMN--------SFNPMSLGNVQLPQ--APMGPRAASPMNHSVQMNSMGSVPG 761
.:.|..||.. |.:|| |.|..|| .|.||..... |..:.|...|
Fly 1075 ------QQQQQQQGQQPLQSCIHPSISPM--GGVMPPQQLRPQGPPGILG-----QQTAAGLGVG 1126
Human 762 MAISPSRMPQPPNMMGAHT--NNMMAQAPAQSQFLP--QNQFPSSSGAMSVGMGQPPAQTGVSQG 822
:.::.:.: .|.:|: .||:|....|....| |.|.|..|||..:.:|.| |
Fly 1127 VGVTNNMV-----TMRSHSPGGNMLALQQQQRMQFPQQQQQQPPGSGAGKMLVGPP--------G 1178
Human 823 QVPGAALPNP-------LNML----------------------GPQASQ---------------- 842
..||..:.|| .|:| .||.|:
Fly 1179 PSPGGMVVNPALSPYQTTNVLTSPVPGQQQQQQFINANGGTGANPQLSEIMKQRHIHQQQQQQQQ 1243
Human 843 -------LPCPPVTQSPLHPTPP----------------PASTAAGMP-------SLQHTTPPGM 877
|| |||...:.| ..|.:...| ..|....||.
Fly 1244 QQQQGMLLP-----QSPFSNSTPLQQQQQQQQQQQQQQQATSNSFSSPMQQQQQGQQQQQQKPGS 1303
Human 878 T----PPQP-------AAPTQPSTPVSSSGQT---PTPTPG--------SVPSATQTQST----- 915
. ||.| |....|.|..|:|..| |:|:|| ..||.....|:
Fly 1304 VLNNMPPTPTSLEALNAGAGAPGTGGSASNVTVSAPSPSPGFLSNGPSIGTPSNNNNNSSANNNP 1368
Human 916 PTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQ----QPTPVHAQP-------------------- 956
|:|.:..|..::.:|.||...|:...|.:|.. ..||..|..
Fly 1369 PSVSSLMQQPLSNRPGTPPYIPASPVPATSASGLAASSTPASAAATCASSGSGSNSSSGATAAGA 1433
Human 957 ----------PGTPLSQAAASIDNRVPTPSSVASAET--------------NSQQPGPDVPVLEM 997
.|||||. |.||:|...|.: :|..|..: |:|.|
Fly 1434 SSTSSSSSAGSGTPLSS--------VSTPTSATMATSSGGGGGGGGNAGGGSSTTPASN-PLLLM 1489
Human 998 K-------------TETQA-------------------------EDTEPDP-GE----------- 1012
. |.|.: :|..|.| ||
Fly 1490 SGGTAGGGTGATTTTSTSSSSRMMSSSSSLSSQMAALEAAARDNDDETPSPSGENTNGSGGSGNA 1554
Human 1013 ----SKGEPRSEMMEEDLQ--------------------------------GASQVKEETDIAEQ 1041
|||:..|...::|:: |.|.:|.|....:.
Fly 1555 GGMASKGKLDSIKQDDDIKKEFMDDSCGGNNDSSQMDCSTGGGKGKNVNNDGTSMIKMEIKTEDG 1619
Human 1042 -------KSEPMEVDEKKPEV-----------------KVEVKEEEESSSNGTA-----SQSTSP 1077
|:|.|:|||..... |..:....:..:.|.| ...|.|
Fly 1620 LDGEVKIKTEAMDVDEAGGSTAGEHHGEGGGGSGVGGGKDNINGAHDGGATGGAVDIKPKTETKP 1684
Human 1078 SQP----------RKKI-FKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKN 1131
..| :||. |.|||||.||:||||.||||:|||:|||.|||||.|||||||:|||.
Fly 1685 LVPEPLAPNAGDKKKKCQFNPEELRTALLPTLEKLYRQEPESVPFRYPVDPQALGIPDYFEIVKK 1749
Human 1132 PMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSL 1196
||||.||:..:..|:|.:||:|||||||||:|||||||||||||::|:||:||||.|||||||:|
Fly 1750 PMDLGTIRTNIQNGKYSDPWEYVDDVWLMFDNAWLYNRKTSRVYRYCTKLSEVFEAEIDPVMQAL 1814
Human 1197 GYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQ----------NRYHFCEKCFTEIQGENVTL 1251
||||||||.|:||.|||||||||||||||.||||| |||.:|:|||.:|||:.|||
Fly 1815 GYCCGRKYTFNPQVLCCYGKQLCTIPRDAKYYSYQNSLKEYGVASNRYTYCQKCFNDIQGDTVTL 1879
Human 1252 GDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTG 1316
||||.|.||.|.||||::.|||.|:.||||:|:|||||.||||||..|.|||.||||||||||..
Fly 1880 GDDPLQSQTQIKKDQFKEMKNDHLELEPFVNCQECGRKQHQICVLWLDSIWPGGFVCDNCLKKKN 1944
Human 1317 RPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVD 1381
..||||||:||||.||:||.::|.|||.||::: ...||||.:|||:||||.|||||||:.|||:
Fly 1945 SKRKENKFNAKRLPTTKLGVYIETRVNNFLKKK-EAGAGEVHIRVVSSSDKCVEVKPGMRRRFVE 2008
Human 1382 SGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLR 1446
.|||...||||.||||||||:||:||||||||||||||:||.||||||||:||||:||||||..|
Fly 2009 QGEMMNEFPYRAKALFAFEEVDGIDVCFFGMHVQEYGSECPAPNTRRVYIAYLDSVHFFRPRQYR 2073
Human 1447 TAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAF 1511
||||||||:||::|||:|||...|||||||||||||||||||.||||||||||||||||||||..
Fly 2074 TAVYHEILLGYMDYVKQLGYTMAHIWACPPSEGDDYIFHCHPTDQKIPKPKRLQEWYKKMLDKGM 2138
Human 1512 AERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKE----ESTAAS 1572
.||||.|||||.|||.||:|.||.|||||||||||||||||||||:|||||::|: |:.||:
Fly 2139 IERIIQDYKDILKQAMEDKLGSAAELPYFEGDFWPNVLEESIKELDQEEEEKRKQAEAAEAAAAA 2203
Human 1573 -----ETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQKLYATMEKHKEVF 1632
|..|.| ||.|...:|..||:||:|:: .|.|.||.:.....||||.|:|||||||||||
Fly 2204 NLFSIEENEVS-GDGKKKGQKKAKKSNKSKAA-QRKNSKKSNEHQSGNDLSTKIYATMEKHKEVF 2266
Human 1633 FVIHLHAGPVINTLPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHT 1697
|||.||:.....:|.||.||||||:||||||||||||||||||:|||||||:::|||.||.|||.
Fly 2267 FVIRLHSAQSAASLAPIQDPDPLLTCDLMDGRDAFLTLARDKHFEFSSLRRAQFSTLSMLYELHN 2331
Human 1698 QGQDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHAHKMVKWGLGLDDEGSSQGEPQSK 1762
||||:||||||.||..||||:|||||:|:||||.|.....|.|||.|.|..:|| ||:..:.:..
Fly 2332 QGQDKFVYTCNHCKTAVETRYHCTVCDDFDLCIVCKEKVGHQHKMEKLGFDIDD-GSALADHKQA 2395
Human 1763 SPQESRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCC 1827
:|||:|:.|||||||||.||||||:|||.||||||||.||||||.||||.|||||:|||||||||
Fly 2396 NPQEARKQSIQRCIQSLAHACQCRDANCRLPSCQKMKLVVQHTKNCKRKPNGGCPICKQLIALCC 2460
Human 1828 YHAKHCQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVP-----QQSLPSPTS 1887
||||:|:|.|||||||.||||||:|||.|.:.||.||:|||:|.|:....| ..::..||.
Fly 2461 YHAKNCEEQKCPVPFCPNIKHKLKQQQSQQKFQQQQLLRRRVALMSRTAAPAALQGPAAVSGPTV 2525
Human 1888 APPGTPTQQPSTPQTPQPPAQPQPSPVSMSPAGFPSVARTQPPTTVSTGKPTS-----------Q 1941
...|.|....|.....| |..|....:.|.| |....|:||:...|.| .
Fly 2526 VSGGVPVVGMSGVAVSQ---QVIPGQAGILPPG----AGGMSPSTVAVPSPVSGGAGAGGMGGMT 2583
Human 1942 VPAPPPPA---------QPPPAAVEAARQIEREAQQQQHLYRVNINNSMPPGRTGMGTPGSQMAP 1997
.|.|..|. .|.|..::..:|::.||.:|| :::. |..|.|.| |||
Fly 2584 SPHPHQPGIGMKPGGGHSPSPNVLQVVKQVQEEAARQQ------VSHG---GGFGKGVP---MAP 2636
Human 1998 VSLNVPR----PNQ-------------------------------------------VSGP---V 2012
..:|.|. ||| :||| |
Fly 2637 PVMNRPMGGAGPNQNVVNQLGGMGVGVGGVGGVGVGGVGGVGVNQLNSGGGNTPGAPISGPGMNV 2701
Human 2013 MPSMPPGQW----------------QQA----------------------PLPQQQPMPGLPRPV 2039
...|...|| .|| |..|||.|.||..|.
Fly 2702 NHLMSMDQWGGGGAGGGGANPGGGNPQARYANNTGGMRQPTHVMQTNLIPPQQQQQMMGGLGGPN 2766
Human 2040 ISMQAQAAVAGPR----MPSVQPPRS-----ISPS------------------ALQDLLRTLKSP 2077
.....|..|.|.. |....||.: :.|| .|..:::.:|:.
Fly 2767 QLGGGQMPVGGQHGGMGMGMGAPPMAGTVGGVRPSPGAGGGGGSATGGGLNTQQLALIMQKIKNN 2831
Human 2078 SSPQQQQQVLNILKSNPQLMAAFIKQR-TAKYVANQPGMQPQPG---LQSQPGMQPQPGMHQQPS 2138
.:.:..|.:|.|||.|||:|||.|||| .::..|...|..|.|| .|.|.|..||....||..
Fly 2832 PTNESNQHILAILKQNPQIMAAIIKQRQQSQNNAAAGGGAPGPGGALQQQQAGNGPQNPQQQQQQ 2896
Human 2139 LQNLNAMQAGVPRPGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQYREMLRRQLLQQQQQ 2203
.|....|| |||....:|.| ..|..|. .||| .||||
Fly 2897 QQQQQVMQ----------QQQMQHMMNQQ-------QGGGGPQ--QMNP-----------NQQQQ 2931
Human 2204 QQQQQQQQQQQQQGSAGMAGGMAGH--------GQFQQ---PQGPG------------------- 2238
|||....|||||.|..|...|:... |..|. ...||
Fly 2932 QQQVNLMQQQQQGGPGGPGSGLPTRMPNMPNALGMLQSLPPNMSPGVSTQGGMVPNQNWNKMRYM 2996
Human 2239 ---GYPPAMQQQQR-----------MQQHLPLQGSSMGQMAA-----QMGQLGQMGQPGLGADST 2284
.|||...|:|| .||..|..|...|...| ..|.:|..|.|| ||.:.
Fly 2997 QMSQYPPPYPQRQRGPHMGGAGPGPGQQQFPGGGGGAGNFNAGGAGGAGGVVGVGGVPG-GAGTV 3060
Human 2285 PNIQQ------ALQQRILQQQ-----------------QMKQQIG---SPG------QPNPMSPQ 2317
|...| |....:|||| |.:||:| .|| |..|:..|
Fly 3061 PGGDQYSMANAAAASNMLQQQQGQVGVGVGVGVKPGPGQQQQQMGVGMPPGMQQQQQQQQPLQQQ 3125
Human 2318 QHMLSGQPQA-------------SHLPGQQIATSLSNQV----RSPAPVQSPRPQSQPPHSSPSP 2365
|.|....|.| :.:.|.....||..|: ||..|::||:| :..|.|:|||
Fly 3126 QMMQVAMPNANAQNPSAVVGGPNAQVMGPPTPHSLQQQLMQSARSSPPIRSPQP-TPSPRSAPSP 3189
Human 2366 RIQP------QPSPHHV------SPQTGSPHPGL------------------------AVTMASS 2394
|..| ||||||| :|| |.||.|: .|.:..:
Fly 3190 RAAPSASPRAQPSPHHVMSSHSPAPQ-GPPHDGMHNHGMHHQSPLPGVPQDVGVGVGVGVGVGVN 3253
Human 2395 IDQGHLGNPEQSAMLPQLNTPSRSALSSELSLVGDTTGDTLEKFVEGL 2442
::.|::|.......||. ..|.|.||||.|
Fly 3254 VNVGNVGVGNAGGALPD-------------------ASDQLTKFVERL 3282
| 
