Protein Alignment CREBBP and nbr1

DIOPT Version :10

• Sequence 1: NP_004371.2
• Gene: CREBBP / 1387
• HGNCID: 2348
• Length: 2442
• Species: Homo sapiens
• Sequence 2: NP_001342955.1
• Gene: nbr1 / 2541353
• PomBaseID: SPBP35G2.11C
• Length: 397
• Species: Schizosaccharomyces pombe
• Alignment Length: 332
• Identity: 76/332 - (22%)
• Similarity: 118/332 - (35%)
• Gaps: 86/332 - (25%)

Human  1604 NKKKPSMPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVI-------NTLPPIVDPDPLLSCDLM 1661
            |...||.|...:.:: .::.|.|.:.:.....|.:..|.:       ||...|:..|........
pombe    17 NHSVPSFPPFHSSVA-NIHFTKENNLKSNIFEHNNNSPTLRSSSVACNTCLKIIRNDSFHCTKCF 80

Human  1662 D--------GRDAFLTLARDKHWEF--SSLRRSKWSTLCMLVELHTQGQDRFVYT-CNECK---H 1712
            |        .:.|||......|:..  ||: .|..|..|.:..:....|..|:|. |:.|:   |
pombe    81 DFDVCRDCYAKQAFLHPCPKPHFVLVRSSI-PSVASLTCSVNSMSVSPQSNFMYAICDHCEQPIH 144

Human  1713 HVETRWHCTVCEDYDLCINCYNTKSHA--HKMVK----WGLGLDDEGSSQGEPQSKSPQ--ESRR 1769
            :|  |:.|:||:|||:|.:|....||:  |..|:    :..||.   |....||..|.:  ||
pombe   145 NV--RYKCSVCDDYDICESCLTDNSHSNTHAFVRITKAYPHGLP---SFHLFPQFLSAELFES-- 202

Human  1770 LSIQRCIQSLVH-ACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGG----CPVCK--QLIALCC 1827
                   .|.|| :.||.|                    |......|    |.||:  .|.:.|.
pombe   203 -------ASTVHRSVQCDN--------------------CLAHPIVGPRFHCLVCEDYDLCSSCV 240

Human  1828 YHAKHCQENKCPV-------PFCLNIKHKLRQQQIQHRLQQAQLMRRRMA-------TMNTRNVP 1878
            .|..|...:...:       |..|:...|.:......:|.:..::...::       ..:.||..
pombe   241 SHVHHDHHSMLRLTREISASPLHLSKPEKPKVLNFDFKLVEDSILPLELSPGCPFYKIWHIRNTS 305

Human  1879 QQSLPSP 1885
            .||.|||
pombe   306 CQSWPSP 312

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CREBBP	NP_004371.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..41
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	74..179
		Interaction with SRCAP. /evidence=ECO:0000269|PubMed:10347196	227..410
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	266..290
		zf-TAZ	363..430	CDD:460457
		KIX	587..667	CDD:366953
		PHA03247	<683..1025	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	794..1083
		Bromo_cbp_like	1087..1194	CDD:99927
		Interaction with histone. /evidence=ECO:0000269|PubMed:24361270	1124..1170
		Interaction with ASF1A. /evidence=ECO:0000269|PubMed:24616510	1162..1180
		RING_CBP-p300	1206..1278	CDD:276805
		PHD_CBP_p300	1280..1311	CDD:277032
		HAT_KAT11	1342..1649	CDD:400497	10/51 (20%)
		Interaction with histone. /evidence=ECO:0000250|UniProtKB:Q09472	1433..1435
		Interaction with TRERF1. /evidence=ECO:0000269|PubMed:11349124	1460..1891		76/332 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1556..1615		4/10 (40%)
		ZZ_CBP	1705..1745	CDD:239077	18/49 (37%)
		zf-TAZ	1772..1840	CDD:460457	15/74 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1874..1959		7/12 (58%)
		Med15	1960..>2423	CDD:312941
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1977..2028
		Creb_binding	2013..2114	CDD:462659
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2112..2263
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2294..2433
nbr1	NP_001342955.1	ZnF_ZZ	56..>91	CDD:197633	5/34 (15%)
		ZZ_NBR1_like	134..177	CDD:239080	17/44 (39%)
		ZZ	210..253	CDD:412288	12/62 (19%)
		NBR1_like	275..385	CDD:271343	8/38 (21%)