DRSC/TRiP Functional Genomics Resources

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Protein Alignment CREBBP and cbp-1

DIOPT Version :10

Sequence 1:NP_004371.2 Gene:CREBBP / 1387 HGNCID:2348 Length:2442 Species:Homo sapiens
Sequence 2:NP_499160.2 Gene:cbp-1 / 176380 WormBaseID:WBGene00000366 Length:2017 Species:Caenorhabditis elegans


Alignment Length:2421 Identity:842/2421 - (34%)
Similarity:1111/2421 - (45%) Gaps:584/2421 - (24%)


- Green bases have known domain annotations that are detailed below.


Human     6 LDGPPNPKRAKLSS---PGFSANDSTDFGSLF-------DLENDLPDELIPNGGELGLL------ 54
            :|.||: |:::..|   .|..|..:.:....|       |::|:.......:||..|..      
 Worm     1 MDEPPS-KKSRADSDYDSGLDALSALESLEAFPTSSKDTDVDNNPSTSAGGSGGPSGSTPHPQGT 64

Human    55 ------NSG--NLVPDAASKHKQLSELLRGG-SGSSINPGIGNVSASS----------PVQQGLG 100
                  |:|  ||.| ..|:.:|..:.:.|| :||.:...:.|.|.:|          |.||...
 Worm    65 PQPAPSNNGGFNLQP-GQSQPQQPPQNMGGGVNGSVLQELLMNPSQTSNNSPRPQAYPPGQQNAF 128

Human   101 GQAQGQPN-SANMASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATS 164
            .::...|| :.||.|..:||:.|........|..|.|.....| .|...|. :.|.|..:|    
 Worm   129 NRSPMMPNGTPNMMSPPSMGRVPGPSPGGPQPPGPGQPQMRPG-QPGMFQG-DQQQQMMMG---- 187

Human   165 SPATSQTGPGICMNANFNQ--THPGLLNSNSGHSLINQAS------QGQAQVMNGSLGAAGRGRG 221
              |..|..||:.....:.|  ..||......|:..:::..      .|:..:|||::..:|    
 Worm   188 --AQGQQFPGMMHRYPYAQGGPPPGAQGMPQGYPGVSRGGPTPGQPMGRGAMMNGAMPRSG---- 246

Human   222 AGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSPFGQPFSQAG-- 284
               |.||....|...:..|    .:.|.||....:...|.|......:.....|.|.|....|  
 Worm   247 ---PMPTQGRPGIPPNQQA----MMQPMMTDRQFMQHGQYGQQRPEFMQQYGRPGGYPMMHQGMM 304

Human   285 ----GQPM-----------GATGVN---------PQLASKQSMVNSLPTFPTDIKNTSVTNVPNM 325
                |||:           |..|::         ||.|:.|.............:..:.......
 Worm   305 MDSNGQPIRGPNQMMMMSNGHPGMSHGPPNGQPGPQAAAAQHAAQQQAAAQAQAQAAAQQQQQQQ 369

Human   326 SQMQTSVGIVPTQA-IATGPTA-------DPEKRKLIQQQLVLLLHAHKCQRREQANGEV----- 377
            .:.:.:.......| .||.|.:       |||||||||||||||||||||.:||:.|.:.     
 Worm   370 REQEAAAAAQRNGAGRATTPGSSMLATHQDPEKRKLIQQQLVLLLHAHKCSQREKENRDFAAKNQ 434

Human   378 ----RACSLPHCRTMKNVLNHMTHCQAG-----------KACQVAHCASSRQIISHWKNCTRHDC 427
                .||:||||.|||.||.|||.|..|           |.|.|||||||||||:|||||:|.||
 Worm   435 PPPHAACTLPHCSTMKEVLTHMTSCNVGRLCHSDTTQTTKKCSVAHCASSRQIIAHWKNCSREDC 499

Human   428 PVCLPLKNASDKRNQQTILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLPY 492
            |||.||     ||.|.|.|......:.|.||.  .|..|.::..:                ||..
 Worm   500 PVCKPL-----KRIQDTPLQFSLPDLANLIGV--NGNSNGSAEGD----------------GLHQ 541

Human   493 MNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNIPAGGITTDQQPPNLISESALPTSLGA 557
            ...|                    .|||             |.||      |.:.|..      .
 Worm   542 FGSP--------------------AMRT-------------GNIT------NSLFEGF------N 561

Human   558 TNPLMNDGSNSGN---IGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPA 619
            .||..| |.|.|.   .|....||...||......|.||..||:|||:|||.|||:||||.|:..
 Worm   562 GNPFQN-GPNRGGPRPPGGNGEIPNLPPPDMPDCTKEWHHQVTKDLRNHLVGKLVKAIFPEPNQE 625

Human   620 ALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQPA 684
            |:.|.|:::|:|||:|||.:|:||||.|:|||||||||||||||||:||:.|||::.....:|.|
 Worm   626 AMNDNRLKDLIAYARKVEKEMFESANDREEYYHLLAEKIYKIQKELQEKKNSRLNQGAAAHDQYA 690

Human   685 LPAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNH 749
            :|                        |.|.:....|:.                 |.|:      
 Worm   691 IP------------------------PSNELAQMLGVE-----------------GGRS------ 708

Human   750 SVQMNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPP 814
              .::|.||  .||::||:..||  ..||..:||..|.|                          
 Worm   709 --DVHSEGS--SMAVAPSQQNQP--WGGAPNSNMHQQIP-------------------------- 741

Human   815 AQTGVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTP 879
                 ..|||                     |.|..|...|                        
 Worm   742 -----PNGQV---------------------PQVNNSSTFP------------------------ 756

Human   880 PQPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQTPVQPPSVATPQS 944
                          |||                .|||.:.|::......||:|        .|..
 Worm   757 --------------SSG----------------NSTPNIGASSTVSAMLQPKT--------EPMD 783

Human   945 SQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASAETNSQQPGPDVPVLEMKTETQAEDTEPD 1009
            .|.                 ..|:.:|.||  ::....::|..|.|.:..:..|        |.|
 Worm   784 DQN-----------------TDSLSSRPPT--AIGFGGSSSSTPAPIMNGIVKK--------EED 821

Human  1010 PGESKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTASQS 1074
            |.||..           |....||:..|         .|.|.||      ||::       |.:.
 Worm   822 PEESSN-----------QAPPSVKDTKD---------GVAESKP------KEQQ-------AKRE 853

Human  1075 TSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIK 1139
            .:|......:|..|:|.:.|:|..|.|.:.: ::.|||.|||.:||.||||.:|:|.||||.|:.
 Worm   854 PTPPPTEDTVFSQEDLIKFLLPVWEKLDKSE-DAAPFRVPVDAKLLNIPDYHEIIKRPMDLETVH 917

Human  1140 RKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKY 1204
            :||..||||...|:.||:|||.:||||||||.|:|||:..||:|:|..|:||||:|:||||.:|.
 Worm   918 KKLYAGQYQNAGQFCDDIWLMLDNAWLYNRKNSKVYKYGLKLSEMFVSEMDPVMKSMGYCCAKKL 982

Human  1205 EFSPQTLCCYGKQLCTIPRDAAYYSYQ-----------NRYHFCEKCFTEIQGENVTLGDDPSQP 1258
            .|:|.:|.|||..:|||.|:..|:.::           .||.:|:|||..:..|.::|.::|:..
 Worm   983 AFTPLSLFCYGAAMCTIAREQQYWVFEQSSTQYNVTVTERYTYCQKCFDALPPEGISLSENPNDR 1047

Human  1259 QTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNC--LKKTGRPRKE 1321
            .....|..|.::||..:|.|||..||.|.||.|:||.||...::|.||:|:.|  .||..:|  :
 Worm  1048 NNMAPKTSFTEQKNSVIDYEPFERCKYCMRKWHRICALHDKKVYPEGFICECCRTAKKYQKP--D 1110

Human  1322 NKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGE--VFVRVVASSDKTVEVKPGMKSRFVDSGE 1384
            ||:.|.:|...:|...||||||.|:::|...||.:  |.:|.:...||..|||..||.::|:|.:
 Worm  1111 NKYLASKLPHNKLSTFLEDRVNGFIKKQLQAEAHKYPVIIRTLCVQDKEAEVKAQMKQKYVESNQ 1175

Human  1385 MSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTAV 1449
            ..|.|||||||:||||.||||:|||||:|||||||.||.||.|||||:||||:|||:||.|||.|
 Worm  1176 FPEKFPYRTKAVFAFEIIDGVEVCFFGLHVQEYGSACPAPNARRVYIAYLDSVHFFQPRELRTDV 1240

Human  1450 YHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAER 1514
            |||:|:|||:|.|.|||...||||||||||||||||||||:||||||||||:||||||:|...|.
 Worm  1241 YHELLLGYLDYAKMLGYTMAHIWACPPSEGDDYIFHCHPPEQKIPKPKRLQDWYKKMLEKGVQEG 1305

Human  1515 IIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAASETTEGSQ 1579
            .:.::|||:|||.:|.||:..:||||||||||||:|:.|:|...||.:||.:|.....|..:|..
 Worm  1306 SVVEFKDIYKQARDDNLTTPTQLPYFEGDFWPNVIEDCIREASNEEAQRKVKEDDDDGEDADGGL 1370

Human  1580 GDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQKLYATMEKHKEVFFVIH---LHAGP 1641
            |...:.|||::|....|....::.||||.. ....|:::.|||:..||||||||.|.   |...|
 Worm  1371 GGGDSGKKKSSKNKKNNLKKNAKMNKKKAG-SITGNEVADKLYSQFEKHKEVFFTIRLVSLQNEP 1434

Human  1642 VINTLPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYT 1706
            .: ...||.|||.|:..|:|||||.|||.||::|||||||||:|:||||:...||........||
 Worm  1435 AV-LAKPISDPDGLMQSDMMDGRDTFLTKAREEHWEFSSLRRAKYSTLCLAYSLHETDSKGMEYT 1498

Human  1707 CNECKHHVETRWHCTVCEDYDLCINCYNTKSHAHKM--VKWGLGLDDEGSSQGEPQSKSPQESRR 1769
            ||:|..  ...|||..|:|:|||..|..|..|.|:|  :|..:|       .||....:...:|.
 Worm  1499 CNKCSS--PAVWHCQSCDDFDLCDGCKPTTQHPHEMEKIKSLIG-------GGEAGDSAAGGTRY 1554

Human  1770 LSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQ 1834
            .||||||.|||||||||:|||...||.||||||||||.||::.||.||||||||||||||||||.
 Worm  1555 ESIQRCIASLVHACQCRDANCRRMSCHKMKRVVQHTKMCKKRINGTCPVCKQLIALCCYHAKHCT 1619

Human  1835 ENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPST 1899
            .:.|.||||:||:.||.:|:...:.:...:|||||..:.:.  ...:.|:|::...|||:..|:.
 Worm  1620 RDACTVPFCMNIRQKLAEQKRSQQRRADMMMRRRMEGLQSH--VGGAAPTPSTVSNGTPSNAPTP 1682

Human  1900 PQTPQP-PA------------QPQPSPVSMS-PAGFPSVARTQPPTTVSTGKPTSQVPAPP---- 1946
            |.:..| ||            |.|.|.|..| |||.              |:|.:.....|    
 Worm  1683 PVSAGPGPAVKGGGVGQVQMQQHQGSHVGGSGPAGM--------------GQPMNSFGGMPGMGL 1733

Human  1947 -PPAQPPPAAVEAARQIEREAQQQQHLYRVNINNS--MP--PGRTGMGTPGSQMAPV-SLNVP-- 2003
             |.||..|.......|             :|.|.|  ||  ||....|.||.|..|: |..:|  
 Worm  1734 GPNAQNGPGLPGMNPQ-------------MNANQSRYMPNGPGLGQSGAPGQQQQPMYSSGMPMQ 1785

Human  2004 RPNQVSGPVMPSMPPGQWQQAPLPQQQPMPGLPRP----------------------VISMQAQA 2046
            ||..:.|     |.|   ||.| .|||..|||..|                      |::||.|.
 Worm  1786 RPGGLGG-----MNP---QQQP-QQQQGHPGLQNPGGRPGGVHGMGQNQPVRNNQDMVMNMQMQN 1841

Human  2047 AVAGPRMPSVQPP--RSISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQR-TAKY 2108
            ....|      ||  .::.|..:: :...||:..:.::::.|.:.||..|.|..|:::.| ....
 Worm  1842 QHQQP------PPFDSTLQPQIMK-INSRLKAAKTEEERETVFSDLKKTPHLFHAWLRMRENQNL 1899

Human  2109 VANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPRPGVPPQQQAMGGLNPQGQALNI 2173
            |.|:        :|....|.......|....|.|...|||..|.|        ||..| ||  |.
 Worm  1900 VPNR--------MQGYSQMSMGSSNLQNLQQQQLQQQQAGAMRGG--------GGFAP-GQ--NN 1945

Human  2174 MNP-GHNPNMASMNPQYREMLRRQLLQQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGP 2237
            ..| ..:...|||||.          .|||..||||...||:||...||......:.|||..|. 
 Worm  1946 SQPRAPSGQFASMNPS----------MQQQYPQQQQGWPQQRQQNPGGMQQNANPYNQFQNRQN- 1999

Human  2238 GGYPPAMQQQQRMQQH 2253
                 .|...|:.|.|
 Worm  2000 -----MMMMPQQQQPH 2010

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CREBBPNP_004371.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..41 10/44 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 74..179 31/116 (27%)
Interaction with SRCAP. /evidence=ECO:0000269|PubMed:10347196 227..410 71/236 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 266..290 7/40 (18%)
zf-TAZ 363..430 CDD:460457 46/86 (53%)
KIX 587..667 CDD:366953 52/79 (66%)
PHA03247 <683..1025 CDD:223021 54/341 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 794..1083 44/288 (15%)
Bromo_cbp_like 1087..1194 CDD:99927 57/106 (54%)
Interaction with histone. /evidence=ECO:0000269|PubMed:24361270 1124..1170 27/45 (60%)
Interaction with ASF1A. /evidence=ECO:0000269|PubMed:24616510 1162..1180 12/17 (71%)
RING_CBP-p300 1206..1278 CDD:276805 25/82 (30%)
PHD_CBP_p300 1280..1311 CDD:277032 15/30 (50%)
HAT_KAT11 1342..1649 CDD:400497 173/311 (56%)
Interaction with histone. /evidence=ECO:0000250|UniProtKB:Q09472 1433..1435 1/1 (100%)
Interaction with TRERF1. /evidence=ECO:0000269|PubMed:11349124 1460..1891 224/435 (51%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1556..1615 17/58 (29%)
ZZ_CBP 1705..1745 CDD:239077 18/41 (44%)
zf-TAZ 1772..1840 CDD:460457 52/67 (78%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1874..1959 25/103 (24%)
Med15 1960..>2423 CDD:312941 92/327 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1977..2028 21/57 (37%)
Creb_binding 2013..2114 CDD:462659 31/125 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2112..2263 43/143 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2294..2433
cbp-1NP_499160.2 Med15 <193..>338 CDD:312941 30/155 (19%)
zf-TAZ 415..502 CDD:460457 46/86 (53%)
KIX 593..673 CDD:366953 52/79 (66%)
Bromo_cbp_like 866..972 CDD:99927 57/106 (54%)
RING_CBP-p300 970..1009 CDD:399179 19/38 (50%)
PHD_CBP_p300 1069..1100 CDD:277032 15/30 (50%)
HAT_KAT11 1131..>1346 CDD:413203 140/214 (65%)
ZZ_CBP 1497..1535 CDD:239077 18/39 (46%)
ZnF_TAZ 1551..1629 CDD:214717 57/77 (74%)
Med15 1629..>2015 CDD:312941 127/462 (27%)
Blue background indicates that the domain is not in the aligned region.

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