DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Erbb4 and Egfr

DIOPT Version :9

Sequence 1:	XP_006495755.1	Gene:	Erbb4 / 13869	MGIID:	104771	Length:	1308	Species:	Mus musculus
Sequence 2:	NP_476759.1	Gene:	Egfr / 37455	FlyBaseID:	FBgn0003731	Length:	1426	Species:	Drosophila melanogaster

Alignment Length:	1447	Identity:	506/1447 - (34%)
Similarity:	692/1447 - (47%)	Gaps:	354/1447 - (24%)

- Green bases have known domain annotations that are detailed below.

Mouse    14 LMAAGTVQPSASQ----------SVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSI 68
            |.|.|...|::.:          .:|.||:::||..|:.|..||.||..|.||..|.||||:|.:
  Fly    77 LGANGVTIPTSLEDKNKNEFVKGKICIGTKSRLSVPSNKEHHYRNLRDRYTNCTYVDGNLELTWL 141

Mouse    69 -EHNRDLSFLRSIREVTGYVLVALNQFRYLPLENLRIIRGTKLY-----EDRYALAIFLNYRKDG 127
             ..|.|||||.:|||||||:|::....:.:....|:||||..|:     |::|||  |:.|.|
  Fly   142 PNENLDLSFLDNIREVTGYILISHVDVKKVVFPKLQIIRGRTLFSLSVEEEKYAL--FVTYSK-- 202

Mouse   128 NFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNMTLVSTNGSSGCGRCHKS 192
               :..|.:.:|.::|||.|....|..||:..||.|.:||.|...:......|.....|.:||:|
  Fly   203 ---MYTLEIPDLRDVLNGQVGFHNNYNLCHMRTIQWSEIVSNGTDAYYNYDFTAPERECPKCHES 264

Mouse   193 CTGRCWGPTENHCQTLTRTVCAEQC-DGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSG 256
            ||..|||....:||..::..|:.|| .||||||...:|||..|||||:||...||.||.||.|.|
  Fly   265 CTHGCWGEGPKNCQKFSKLTCSPQCAGGRCYGPKPRECCHLFCAGGCTGPTQKDCIACKNFFDEG 329

Mouse   257 ACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIK 321
            .|..:||....|||||:.||.|...||.|||.|||:||.:.:.|:.:|||:||..||  ::.|
  Fly   330 VCKEECPPMRKYNPTTYVLETNPEGKYAYGATCVKECPGHLLRDNGACVRSCPQDKM--DKGG-- 390

Mouse   322 MCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHG--DPYNAID-- 382
            .|.||...|||.|.|:        ..:.:.|||.|.|||.|:||:..|.....|  |.|....
  Fly   391 ECVPCNGPCPKTCPGV--------TVLHAGNIDSFRNCTVIDGNIRILDQTFSGFQDVYANYTMG 447

Mouse   383 ----AIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGL-SLLILKQQGI 442
                .:|||:|.||.||:||||:|||:...|...:.|.|.||.||.||.|...: :.|.:.:..:
  Fly   448 PRYIPLDPERLEVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKSSL 512

Mouse   443 TSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRRAENCTAEGMVCNHLC 507
            .||:.::||:||:|::.|..|.:|||...|.|..:.....|::.:.:|.||:.|...|.:|:..|
  Fly   513 YSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADLCEKNGTICSDQC 577

Mouse   508 SNDGCWGPGPDQCLSCRRFSRGKICIESCNLYDGEFREFENGSICVECDSQCEKMEDGLLTCHGP 572
            :.|||||.|.||||:|:.|:....||..|......:: |:|.: |..|..:|.       ||:|.
  Fly   578 NEDGCWGAGTDQCLTCKNFNFNGTCIADCGYISNAYK-FDNRT-CKICHPECR-------TCNGA 633

Mouse   573 GPDNCTKCSHFKDGPNCVEKCP-----------------DGLQGANSFI---------------- 604
            |.|:|.:|.|.:||.:||.:||                 ||..|....|
  Fly   634 GADHCQECVHVRDGQHCVSECPKNKYNDRGVCRECHATCDGCTGPKDTIGIGACTTCNLAIINND 698

Mouse   605 ----------------------------------------------------------------F 605
                                                                            :
  Fly   699 ATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHY 763

Mouse   606 K-------------YADQD-RECHPCHPNCTQGCNGPTSHDC----------------------- 633
            |             |.|:: |||..|||.| .||.||.:.||
  Fly   764 KRREQCETECPADHYTDEEQRECFQCHPEC-NGCTGPGADDCKSCRNFKLFDANETGPYVNSTMF 827

Mouse   634 ------------IYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIMALTFAVYV----------- 675
                        :.|.:|...  |..|.:|..::.:...|.:.:|..:|.||.|
  Fly   828 NCTSKCPLEMRHVNYQYTAIG--PYCAASPPRSSKITANLDVNMIFIITGAVLVPTICILCVVTY 890

Mouse   676 --RRKSIKKKRALRRFLE---TELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKG 735
              |:|...||..::..:.   .|..|||.||....|..:|||:|:.||::..|||.||||.||||
  Fly   891 ICRQKQKAKKETVKMTMALSGCEDSEPLRPSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYKG 955

Mouse   736 IWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMP 800
            :||||||.||||||||.|.::||.:::.||:.||.||||::|.:|::||.||:|..:.|:|||||
  Fly   956 VWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQMMLITQLMP 1020

Mouse   801 HGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLA 865
            .|||||||..::|.|||:.||||..||||||.||||:||||||||||||||::|:.|||||||||
  Fly  1021 LGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLA 1085

Mouse   866 RLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIP 930
            :||..|..||.|.||||||||:|||||..|.||.:||||::|||||||:|||.:|::.||.::||
  Fly  1086 KLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIP 1150

Mouse   931 DLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKL 995
            ||:|.|.:|.||.||::|:|..::.||.:||..||.||:|...|:..||||.|||.|.||...:|
  Fly  1151 DLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTRL 1215

Mouse   996 PSPNDSKFFQNLLDEEDL-----------EDMMDAEEYLVPQAFNIPPPIYTSRTRIDSNRSEIG 1049
            |:....       ||:||           |.:.:.::||.|:|  .|.|         |:|::..
  Fly  1216 PAYTSQ-------DEKDLIRKLAPTTDGSEAIAEPDDYLQPKA--APGP---------SHRTDCT 1262

Mouse  1050 HSPPPAYTPMSGNQFVYQDGGFATQQGMPMPYRATTSTIPEAPVAQGATAEMFDDSCCNGTLRKP 1114
            ...|..      |::...            |....:||              .||
  Fly  1263 DEIPKL------NRYCKD------------PSNKNSST--------------GDD---------- 1285

Mouse  1115 VAPHVQEDSSTQRYSADPTVFAPERNPRGEL--DEEGYMTPM---HDKPKQEYLNPVEENPFVSR 1174
                 :.|||.:.....        |.|.:|  ||:.|:.|.   .........||.:.|.....
  Fly  1286 -----ETDSSAREVGVG--------NLRLDLPVDEDDYLMPTCQPGPNNNNNINNPNQNNMAAVG 1337

Mouse  1175 RKNGDLQ------ALDNPEY----------------------------------HSASSGPPKAE 1199
            ...|.:.      ::|||||                                  ....|.|..::
  Fly  1338 VAAGYMDLIGVPVSVDNPEYLLNAQTLGVGESPIPTQTIGIPVMGVPGTMEVKVPMPGSEPTSSD 1402

Mouse  1200 DEYVN------EPLYLN 1210
            .||.|      :||:.|
  Fly  1403 HEYYNDTQRELQPLHRN 1419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Erbb4	XP_006495755.1	Recep_L_domain	55..165	CDD:366426	47/115 (41%)
		Furin-like	186..334	CDD:366287	74/148 (50%)
		Recep_L_domain	358..475	CDD:366426	49/125 (39%)
		GF_recep_IV	502..634	CDD:373332	56/277 (20%)
		TM_ErbB4	642..685	CDD:213053	13/55 (24%)
		PTKc_HER4	710..1012	CDD:173655	180/301 (60%)
Egfr	NP_476759.1	Recep_L_domain	419..547	CDD:279382	50/127 (39%)
		GF_recep_IV	572..684	CDD:291509	40/120 (33%)
		FU	573..>606	CDD:238021	16/32 (50%)
		FU	617..659	CDD:214589	18/49 (37%)
		FU	662..716	CDD:214589	4/53 (8%)
		FU	739..786	CDD:238021	4/46 (9%)
		FU	784..834	CDD:214589	13/50 (26%)
		PTKc_EGFR_like	930..1208	CDD:270648	173/277 (62%)
		STYKc	938..1194	CDD:214568	160/255 (63%)
		Recep_L_domain	128..239	CDD:279382	47/117 (40%)
		Furin-like	253..401	CDD:279142	72/151 (48%)
		FU	255..292	CDD:214589	14/36 (39%)
		FU	302..345	CDD:238021	24/42 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	341	1.000	Domainoid score	I1078
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45861
OrthoDB	1	1.010	-	-		D51516at33208
OrthoFinder	1	1.000	-	-		FOG0000755
OrthoInspector	1	1.000	-	-		otm42670
orthoMCL	1	0.900	-	-		OOG6_101159
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5222
SonicParanoid	1	1.000	-	-		X448
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.820