DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Erbb2 and Egfr

DIOPT Version :9

Sequence 1:	NP_001003817.1	Gene:	Erbb2 / 13866	MGIID:	95410	Length:	1256	Species:	Mus musculus
Sequence 2:	NP_476759.1	Gene:	Egfr / 37455	FlyBaseID:	FBgn0003731	Length:	1426	Species:	Drosophila melanogaster

Alignment Length:	1446	Identity:	478/1446 - (33%)
Similarity:	672/1446 - (46%)	Gaps:	360/1446 - (24%)

- Green bases have known domain annotations that are detailed below.

Mouse    24 QVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLP-ANASLSFLQDIQEVQGYMLIA 87
            ::|.||..:|.:|::.|.|...||..|..|..|.||||||:|| .|..||||.:|:||.||:||:
  Fly   100 KICIGTKSRLSVPSNKEHHYRNLRDRYTNCTYVDGNLELTWLPNENLDLSFLDNIREVTGYILIS 164

Mouse    88 HNRVKHVPLQRLRIVRGTQLF-----EDKYALAVLDNRDPLDNVTTAAPGRTPEGLRELQLRSLT 147
            |..||.|...:|:|:||..||     |:||||.|                 |...:..|::..|.
  Fly   165 HVDVKKVVFPKLQIIRGRTLFSLSVEEEKYALFV-----------------TYSKMYTLEIPDLR 212

Mouse   148 EILKGGVLIRGNPQLCYQDMVLWKDVLRKNNQLAPVDMD-TNRSRACPPCAPTCKDNHCWGESPE 211
            ::|.|.|....|..||:...:.|.::: .|...|..:.| |...|.||.|..:| .:.||||.|:
  Fly   213 DVLNGQVGFHNNYNLCHMRTIQWSEIV-SNGTDAYYNYDFTAPERECPKCHESC-THGCWGEGPK 275

Mouse   212 DCQILTGTICTSGCA--RCKGRLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALIT 274
            :||..:...|:..||  ||.|..|.:|||..||.|||||...||:||.:|...|:|:..||.:..
  Fly   276 NCQKFSKLTCSPQCAGGRCYGPKPRECCHLFCAGGCTGPTQKDCIACKNFFDEGVCKEECPPMRK 340

Mouse   275 YNTDTFESMLNPEGRYTFGASCVTTCPYNYLSTEVGSCTLVCPPNNQEVTAEDGTQRCEKCSKPC 339
            ||..|:....||||:|.:||:||..|| .:|..:.|:|...||.:..:...|     |..|:.||
  Fly   341 YNPTTYVLETNPEGKYAYGATCVKECP-GHLLRDNGACVRSCPQDKMDKGGE-----CVPCNGPC 399

Mouse   340 AGVCYGLGMEHLRGARAITSDNIQEFAGCKKIFGSLAFLPESFDG------NPSSG--VAPLKPE 396
            ...|.|:.:.|        :.||..|..|..|.|::..|.::|.|      |.:.|  ..||.||
  Fly   400 PKTCPGVTVLH--------AGNIDSFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYIPLDPE 456

Mouse   397 HLQVFETLEEITGYLYISAWPESFQDLSVFQNLRVIRGRILHDGAY-SLTLQGLGIHSLGLRSLR 460
            .|:||.|::||||||.|......|::||.|:||..|.||.|.:..: :|.:....::||.:|:|:
  Fly   457 RLEVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKSSLYSLEMRNLK 521

Mouse   461 ELGSGLALIHRNTHLCFVNTVPWDQLFRNPHQALLHSGNRPEEACGLEGLVCNSLCARGHCWGPG 525
            ::.||..:|..|..||:|:.:.|..:.:.|.|.:..:.|...:.|...|.:|:..|....|||.|
  Fly   522 QISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADLCEKNGTICSDQCNEDGCWGAG 586

Mouse   526 PTQCVNCSQFLRGQECVEECRVWKGLPREYVRGKH------CLPCHPECQPQNSSETCYGSEADQ 584
            ..||:.|..|.....|:.:|        .|:...:      |..|||||:      ||.|:.||.
  Fly   587 TDQCLTCKNFNFNGTCIADC--------GYISNAYKFDNRTCKICHPECR------TCNGAGADH 637

Mouse   585 CEACAHYKDSSSCVARCP--------------------SGVK----------------------- 606
            |:.|.|.:|...||:.||                    :|.|
  Fly   638 CQECVHVRDGQHCVSECPKNKYNDRGVCRECHATCDGCTGPKDTIGIGACTTCNLAIINNDATVK 702

Mouse   607 ---------PDLSYMPIWKY--PDEEG---------ICQPC-PI---------------NCTH-- 633
                     || .|  .|:|  |.|:|         :|:.| |:               .|||
  Fly   703 RCLLKDDKCPD-GY--FWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYK 764

Mouse   634 -----------------------------------------SC-----VDLDERG---------- 642
                                                     ||     .|.:|.|
  Fly   765 RREQCETECPADHYTDEEQRECFQCHPECNGCTGPGADDCKSCRNFKLFDANETGPYVNSTMFNC 829

Mouse   643 ---CPAEQR--------------ASP-----------VTFIIATVVGVLLFLIIVVVIGILIKRR 679
               ||.|.|              |||           |..|......||:..|.::.:...|.|:
  Fly   830 TSKCPLEMRHVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITGAVLVPTICILCVVTYICRQ 894

Mouse   680 RQKIRKYT--MRRLLQETELVEPLTPSGAVPNQAQMRILKETELRKLKVLGSGAFGTVYKGIWIP 742
            :||.:|.|  |...|...|..|||.||....|..::||:|:.||||..|||.||||.||||:|:|
  Fly   895 KQKAKKETVKMTMALSGCEDSEPLRPSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYKGVWVP 959

Mouse   743 DGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCL 807
            :|||||||||||.|.::|..::::|.|.|||:||.|....:.:||.:|::|.:.|:|||||.|||
  Fly   960 EGENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQMMLITQLMPLGCL 1024

Mouse   808 LDHVREHRGRLGSQDLLNWCVQIAKGMSYLEEVRLVHRDLAARNVLVKSPNHVKITDFGLARLLD 872
            ||:||.:|.::||:.||||..|||||||||||.||||||||||||||::|:.|||||||||:||.
  Fly  1025 LDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLS 1089

Mouse   873 IDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLE 937
            .|..||.|.|||:||||:|||.|..|.||.:||||::|||:|||:|||.:|::.|||::||||:|
  Fly  1090 SDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIE 1154

Mouse   938 KGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDL----GPS 998
            .|.:|.||.||::|:|..::.||.:|:..||.|::|.:.|:..||||.|::.|..:..    ..:
  Fly  1155 VGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTRLPAYT 1219

Mouse   999 SPMDSTFYRSLLEDDDMGE-LVDAEEYLVPQQGFFSPDPALGTGSTAHRRHRSSSARSGGGELTL 1062
            |..:....|.|....|..| :.:.::||.|:.   :|.|:          ||:
  Fly  1220 SQDEKDLIRKLAPTTDGSEAIAEPDDYLQPKA---APGPS----------HRT------------ 1259

Mouse  1063 GLEPSEEEPP-----RSPLAPSEGAGSDVFDG---DLAVGVTKGLQSLSPHDLSPLQRYSEDPTL 1119
              :.::|.|.     :.|...:...|.|..|.   ::.||..:                     |
  Fly  1260 --DCTDEIPKLNRYCKDPSNKNSSTGDDETDSSAREVGVGNLR---------------------L 1301

Mouse  1120 PLPPETDGYVAPLACSPQPEYVNQPEVRPQSPLTPEGPPPPIRPAGATLERPKTLSPGKNGVV-- 1182
            .||.:.|.|:.| .|.|.|...|                        .:..|...:....||.
  Fly  1302 DLPVDEDDYLMP-TCQPGPNNNN------------------------NINNPNQNNMAAVGVAAG 1341

Mouse  1183 -KDVFAFGGAVENPEYL--APRAGTASQPHPSPAFSPAFDNLYYWDQNSSEQGPP----PSTFE- 1239
             .|:.....:|:|||||  |...|....|.|:...                 |.|    |.|.|
  Fly  1342 YMDLIGVPVSVDNPEYLLNAQTLGVGESPIPTQTI-----------------GIPVMGVPGTMEV 1389

Mouse  1240 ------GTPTAENPEY 1249
                  ..||:.:.||
  Fly  1390 KVPMPGSEPTSSDHEY 1405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Erbb2	NP_001003817.1	Recep_L_domain	52..174	CDD:279382	48/127 (38%)
		Furin-like	190..339	CDD:279142	60/150 (40%)
		FU	236..281	CDD:238021	22/44 (50%)
		Recep_L_domain	367..487	CDD:279382	46/128 (36%)
		GF_recep_IV	511..644	CDD:291509	53/278 (19%)
		FU	512..>545	CDD:238021	11/32 (34%)
		FU	558..604	CDD:214589	19/71 (27%)
		TM_ErbB2	642..685	CDD:213055	17/80 (21%)
		Nuclear localization signal. /evidence=ECO:0000250	677..690		6/14 (43%)
		Required for interaction with KPNB1 and EEA1. /evidence=ECO:0000250	677..690		6/14 (43%)
		PTKc_HER2	713..991	CDD:270684	163/277 (59%)
		Pkinase_Tyr	721..977	CDD:285015	153/255 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1030..1180		23/157 (15%)
		Interaction with PIK3C2B. /evidence=ECO:0000250	1196..1198		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1200..1219		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1224..1256		9/37 (24%)
Egfr	NP_476759.1	Recep_L_domain	419..547	CDD:279382	46/127 (36%)
		GF_recep_IV	572..684	CDD:291509	34/125 (27%)
		FU	573..>606	CDD:238021	11/32 (34%)
		FU	617..659	CDD:214589	19/47 (40%)
		FU	662..716	CDD:214589	5/56 (9%)
		FU	739..786	CDD:238021	5/46 (11%)
		FU	784..834	CDD:214589	5/49 (10%)
		PTKc_EGFR_like	930..1208	CDD:270648	163/277 (59%)
		STYKc	938..1194	CDD:214568	153/255 (60%)
		Recep_L_domain	128..239	CDD:279382	48/127 (38%)
		Furin-like	253..401	CDD:279142	62/154 (40%)
		FU	255..292	CDD:214589	15/37 (41%)
		FU	302..345	CDD:238021	21/42 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	341	1.000	Domainoid score	I1078
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45861
OrthoDB	1	1.010	-	-		D51516at33208
OrthoFinder	1	1.000	-	-		FOG0000755
OrthoInspector	1	1.000	-	-		otm42670
orthoMCL	1	0.900	-	-		OOG6_101159
Panther	1	1.100	-	-	LDO	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X448
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.790