DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATF2 and Atf3

DIOPT Version :9

Sequence 1:	NP_001243019.1	Gene:	ATF2 / 1386	HGNCID:	784	Length:	505	Species:	Homo sapiens
Sequence 2:	NP_001259125.1	Gene:	Atf3 / 43867	FlyBaseID:	FBgn0028550	Length:	688	Species:	Drosophila melanogaster

Alignment Length:	380	Identity:	85/380 - (22%)
Similarity:	145/380 - (38%)	Gaps:	92/380 - (24%)

- Green bases have known domain annotations that are detailed below.

Human   159 PTSAIVRPASLQVPNVLLTSSDSSVIIQQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHL-- 221
            |.:..:..:.:.:.|.|...|.||.....|..|..||:....|.|:  |:|.|       .|.
  Fly    26 PKTPEILNSLIAMTNPLENFSYSSAAAAAAAVSVASSSASCSAAST--PVVTV-------RHFNG 81

Human   222 -PNGQTMPVAIPASITSSNVHVPAAVPLVRPVTMVPSVPGIPGPSSPQPVQSEAKMRLKAAL--- 282
             ||||:.......|..|.:       ||..|.          |.::...||......:|..|
  Fly    82 HPNGQSHSQDSSHSSCSGS-------PLDSPA----------GTATTPSVQQTCSRLIKEGLKLS 129

Human   283 TQQHPPVTNGDTVKGHGSGLVRTQSEESRPQS-------------------------LQQPATST 322
            .|....::..|:    .||..:..|:.||..|                         .::.:...
  Fly   130 IQSKRKLSTCDS----SSGSEQPHSKYSRRSSNHNGHSGSSNNYSGSMSNANDLDDDCEESSDDD 190

Human   323 TETPASPAHTTPQTQSTSGRRRRAANEDPDEKRRKFLERNRAAASRCRQKRKVWVQSLEKKAEDL 387
            :||.:.|...||              ||.|.:||: .|||:.||::||.|::...|:|.|::|.|
  Fly   191 SETKSQPKGLTP--------------EDEDRRRRR-RERNKIAATKCRMKKRERTQNLIKESEVL 240

Human   388 SSLNGQLQSEVTLLRNEVAQLKQLLLAHKDCPVTAMQKKSGYHTADKDDSSEDISVPSSPHTEAI 452
            .:.|.:|:::|..|..|..:|..:|.:|      ..|:..|...     .|:.:..|:..:...:
  Fly   241 DTQNVELKNQVRQLETERQKLVDMLKSH------GCQRAGGCQL-----PSQLLQSPAQKYLSEL 294

Human   453 QHSSVSTS--NGVSSTSKAEAVATSVLTQMADQSTEPALSQIVMAPSSQSQPSGS 505
            :..:||..  |..::..:.::: .|:.|......|..|::|  ..|:...:||.|
  Fly   295 ELETVSIDGPNSGNNNQRLQSI-PSMATFKYGSKTAAAMAQ--QLPNGYCKPSPS 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATF2	NP_001243019.1	Nuclear export signal 1 (N-NES)	1..7
		C2H2 Zn finger	27..49	CDD:275370
		GCN4_cent	65..102	CDD:213399
		Herpes_BLLF1	<90..342	CDD:282904	43/213 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	125..155
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	259..373		30/141 (21%)
		Essential for its histone acetyltransferase activity	296..299		0/2 (0%)
		bZIP_ATF2	354..414	CDD:269835	22/59 (37%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	354..374		10/19 (53%)
		coiled coil	355..406	CDD:269835	20/50 (40%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	380..408		9/27 (33%)
		Nuclear export signal 2 (C-NES)	405..414		2/8 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	425..472		6/48 (13%)
Atf3	NP_001259125.1	bZIP_ATF3	215..268	CDD:269870	18/52 (35%)
Atf3	NP_001259125.1	coiled coil	215..265	CDD:269870	17/49 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1414
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810