DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Eps15l1 and Eps-15

DIOPT Version :9

Sequence 1:XP_006509607.1 Gene:Eps15l1 / 13859 MGIID:104582 Length:923 Species:Mus musculus
Sequence 2:NP_611965.2 Gene:Eps-15 / 37961 FlyBaseID:FBgn0035060 Length:1253 Species:Drosophila melanogaster


Alignment Length:944 Identity:340/944 - (36%)
Similarity:472/944 - (50%) Gaps:178/944 - (18%)


- Green bases have known domain annotations that are detailed below.


Mouse    18 LYESYYKQVDPAYTGRVGASEAALFLKKSGLSDIILGKIWDLADPEGKGFLDKQGFYVALRLVAC 82
            :||:|||.:||..||.:.|..||.|||||||||::|.:||||:||.|||||||.||:|||:||:.
  Fly    15 VYEAYYKLIDPKGTGAIEAMTAAKFLKKSGLSDVVLSRIWDLSDPSGKGFLDKPGFFVALKLVSL 79

Mouse    83 AQSGHEVTLSSLSLTMP-PPKFHDTSSPL--------MATQSSAETHWAVRVEEKAKFDGIFESL 138
            :|:|...:::::.|.:. |||..:....:        :|:...|...|::.|.::.|::.:||||
  Fly    80 SQAGQVASMANIYLDIANPPKLGELPKTMPSRIQTVPVASGGVANGDWSIGVIDRLKYEQLFESL 144

Mouse   139 LPVNGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDGHLDRDEFAVAMHLVYRALEKEPVPSI 203
            .|.||:|.|:|||.|||:||||:.:||.:|||:|.||||:||..||.|||||||:.|:|..:||:
  Fly   145 HPSNGMLPGNKVKGVLMDSKLPMSILGTIWDLADQDKDGNLDMHEFVVAMHLVYQTLQKRTIPSV 209

Mouse   204 LPP-------------PLIPPSKR-----------------------KKTVFAGAVPVLPASPPP 232
            |||             |.:||...                       |......|:|.||.:.||
  Fly   210 LPPELRKPGGAGPPPKPAMPPPPAGAAMPRAPSGEGFGDGGFVANFPKDIAPPAAIPPLPVAVPP 274

Mouse   233 KDSLRSTPSHGSVSS--LNSTGSLSPKHSVKQPPVA---WVVPVADKMRFDEIFLKTDLDLDGYV 292
               :...|..|:|||  |..|..|.|   :..|.:|   |||..||..||:|||.::|||.||.|
  Fly   275 ---MTRIPPVGAVSSQPLIQTDPLIP---IGAPVMANADWVVTPADLKRFEEIFRQSDLDKDGLV 333

Mouse   293 SGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKEQFALAMYFIQQKVSKGIDPPQVLSPDMV 357
            ||.|||:||:.||:.|..||.||||.||.|:|||:.|||||||:|:::| .:|:|||.||:.:||
  Fly   334 SGLEVKDIFIKSGIPQRSLADIWALCDTNQSGKLTVEQFALAMWFVERK-QRGVDPPHVLNANMV 397

Mouse   358 PPSERGTPI-----PDSSSTLASGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTS 417
            |||.|.|..     |.......|.     .||:.||:||.:|.||:..||.:|.:||..:|.|..
  Fly   398 PPSMRATVAGVDLQPQEVKPTYSN-----PELEMISKEIEELARERRVLETEIAQKEADVRIKNG 457

Mouse   418 EVQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQTISSLKTQI 482
            ||:.||::||..|::|::||.|:.:||.|||::..|.:....:|::|........:.::.::.|.
  Fly   458 EVRSLQSELDTLTATLKQLENQRGEAQKRLDDLQAQVSHNTAVLANVSLDISRTNEQVTKIRDQC 522

Mouse   483 QSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRAQLETILRSLKCTQDDINQARSKLSQ 547
            ..||..:..||.:||..:|||.:|:.||..|::...:...:|..:...|:.||..|:..||.::|
  Fly   523 HMQEVTINEQEGELNAKRSELQKLKDEEASLQKEYDSNNRELSKLTNHLQATQLQISSVRSMVTQ 587

Mouse   548 LQESHLEAHRSL-----EQYDQVPDGVSGTSL---PDL----ATLNEGILLAERGGFGAMDDPFK 600
            |.|:..:...:|     ...:|..:.||...|   ||.    .||.:.:.|.:       ||||:
  Fly   588 LLETQRQMTDALLICRAAMENQNAELVSEYQLKIEPDFDEARKTLTKEVQLPK-------DDPFE 645

Mouse   601 NKALLFSNNSQELHPDPFQAEDPFKSDPFKGADPFKGDPFQSDPFSEQQTAATDPFGGDPFKES- 664
                  .|||...:    ||.:.|      |:|||.|.|......|   |...|.|......:| 
  Fly   646 ------ENNSGAAN----QATNGF------GSDPFSGQPVNKPAIS---TGFDDSFNMSSGFDSG 691

Mouse   665 -DPFHSSSSDDFFKKQTKNDPFTSDPFTKNPSLPSKLDPFESSDPFSSSSISSKGSDPFGTLD-P 727
             |.|..|.:...| .||:.|||.||.|..|.|  :.:.|....|.|        |||||..|. |
  Fly   692 FDAFGQSGAGSAF-GQTQRDPFGSDAFAANKS--NAITPEPGKDDF--------GSDPFAALHAP 745

Mouse   728 FGSSSFSSAEGFADFSQMSKPPPSGPFSSSLGGTGFSDDPFKSKQDTPALPPKKP--APPRPKPP 790
            .|.....|..     :|.|.|||                  :.:..:|||||||.  .||||.||
  Fly   746 TGQGQVLSPN-----AQKSGPPP------------------RPESPSPALPPKKSKVPPPRPAPP 787

Mouse   791 SEA-AAGEKGTVVYTLLGGQSTPVSQLGSSDFPESPDPFQPLGADSGDPFQNK-----KGFGDPF 849
            ..| ..|..|:      ||..      |.:||               |.|.||     .......
  Fly   788 RAAQPTGGFGS------GGGG------GFADF---------------DDFDNKLHHIPSAPSPSA 825

Mouse   850 SGKDPFAPSSSAKPPKTSSSGFAD-FTSFGNEEQ 882
            :...|..|:..|..|..|.|...| ||.|.:..|
  Fly   826 TALSPLPPTLPAPIPVVSGSSLLDSFTLFDDPGQ 859

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Eps15l1XP_006509607.1 EF-hand_4 13..103 CDD:332633 47/85 (55%)
EH 121..200 CDD:197477 45/78 (58%)
EH 266..362 CDD:197477 59/98 (60%)
Smc <383..>564 CDD:224117 60/185 (32%)
Eps-15NP_611965.2 EH 16..82 CDD:238009 42/65 (65%)
EH 126..215 CDD:197477 50/88 (57%)
EH 137..202 CDD:238009 40/64 (63%)
EH 307..402 CDD:197477 58/95 (61%)
EH 318..384 CDD:238009 41/66 (62%)
RILP-like <445..548 CDD:304877 35/102 (34%)
Spc24 529..>584 CDD:285486 17/54 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 154 1.000 Domainoid score I4250
eggNOG 1 0.900 - - E1_KOG0998
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H31881
Inparanoid 1 1.050 458 1.000 Inparanoid score I1564
Isobase 1 0.950 - 0.721928 Normalized mean entropy S4078
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D360276at33208
OrthoFinder 1 1.000 - - FOG0001628
OrthoInspector 1 1.000 - - otm42994
orthoMCL 1 0.900 - - OOG6_101578
Panther 1 1.100 - - O PTHR11216
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R396
SonicParanoid 1 1.000 - - X924
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1514.810

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