Protein Alignment Eps15l1 and Eps-15

DIOPT Version :10

• Sequence 1: XP_006509607.1
• Gene: Eps15l1 / 13859
• MGIID: 104582
• Length: 923
• Species: Mus musculus
• Sequence 2: NP_611965.2
• Gene: Eps-15 / 37961
• FlyBaseID: FBgn0035060
• Length: 1253
• Species: Drosophila melanogaster
• Alignment Length: 944
• Identity: 340/944 - (36%)
• Similarity: 472/944 - (50%)
• Gaps: 178/944 - (18%)

Mouse    18 LYESYYKQVDPAYTGRVGASEAALFLKKSGLSDIILGKIWDLADPEGKGFLDKQGFYVALRLVAC 82
            :||:|||.:||..||.:.|..||.|||||||||::|.:||||:||.|||||||.||:|||:||:.
  Fly    15 VYEAYYKLIDPKGTGAIEAMTAAKFLKKSGLSDVVLSRIWDLSDPSGKGFLDKPGFFVALKLVSL 79

Mouse    83 AQSGHEVTLSSLSLTMP-PPKFHDTSSPL--------MATQSSAETHWAVRVEEKAKFDGIFESL 138
            :|:|...:::::.|.:. |||..:....:        :|:...|...|::.|.::.|::.:||||
  Fly    80 SQAGQVASMANIYLDIANPPKLGELPKTMPSRIQTVPVASGGVANGDWSIGVIDRLKYEQLFESL 144

Mouse   139 LPVNGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDGHLDRDEFAVAMHLVYRALEKEPVPSI 203
            .|.||:|.|:|||.|||:||||:.:||.:|||:|.||||:||..||.|||||||:.|:|..:||:
  Fly   145 HPSNGMLPGNKVKGVLMDSKLPMSILGTIWDLADQDKDGNLDMHEFVVAMHLVYQTLQKRTIPSV 209

Mouse   204 LPP-------------PLIPPSKR-----------------------KKTVFAGAVPVLPASPPP 232
            |||             |.:||...                       |......|:|.||.:.||
  Fly   210 LPPELRKPGGAGPPPKPAMPPPPAGAAMPRAPSGEGFGDGGFVANFPKDIAPPAAIPPLPVAVPP 274

Mouse   233 KDSLRSTPSHGSVSS--LNSTGSLSPKHSVKQPPVA---WVVPVADKMRFDEIFLKTDLDLDGYV 292
               :...|..|:|||  |..|..|.|   :..|.:|   |||..||..||:|||.::|||.||.|
  Fly   275 ---MTRIPPVGAVSSQPLIQTDPLIP---IGAPVMANADWVVTPADLKRFEEIFRQSDLDKDGLV 333

Mouse   293 SGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKEQFALAMYFIQQKVSKGIDPPQVLSPDMV 357
            ||.|||:||:.||:.|..||.||||.||.|:|||:.|||||||:|:::| .:|:|||.||:.:||
  Fly   334 SGLEVKDIFIKSGIPQRSLADIWALCDTNQSGKLTVEQFALAMWFVERK-QRGVDPPHVLNANMV 397

Mouse   358 PPSERGTPI-----PDSSSTLASGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTS 417
            |||.|.|..     |.......|.     .||:.||:||.:|.||:..||.:|.:||..:|.|..
  Fly   398 PPSMRATVAGVDLQPQEVKPTYSN-----PELEMISKEIEELARERRVLETEIAQKEADVRIKNG 457

Mouse   418 EVQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQTISSLKTQI 482
            ||:.||::||..|::|::||.|:.:||.|||::..|.:....:|::|........:.::.::.|.
  Fly   458 EVRSLQSELDTLTATLKQLENQRGEAQKRLDDLQAQVSHNTAVLANVSLDISRTNEQVTKIRDQC 522

Mouse   483 QSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRAQLETILRSLKCTQDDINQARSKLSQ 547
            ..||..:..||.:||..:|||.:|:.||..|::...:...:|..:...|:.||..|:..||.::|
  Fly   523 HMQEVTINEQEGELNAKRSELQKLKDEEASLQKEYDSNNRELSKLTNHLQATQLQISSVRSMVTQ 587

Mouse   548 LQESHLEAHRSL-----EQYDQVPDGVSGTSL---PDL----ATLNEGILLAERGGFGAMDDPFK 600
            |.|:..:...:|     ...:|..:.||...|   ||.    .||.:.:.|.:       ||||:
  Fly   588 LLETQRQMTDALLICRAAMENQNAELVSEYQLKIEPDFDEARKTLTKEVQLPK-------DDPFE 645

Mouse   601 NKALLFSNNSQELHPDPFQAEDPFKSDPFKGADPFKGDPFQSDPFSEQQTAATDPFGGDPFKES- 664
                  .|||...:    ||.:.|      |:|||.|.|......|   |...|.|......:|
  Fly   646 ------ENNSGAAN----QATNGF------GSDPFSGQPVNKPAIS---TGFDDSFNMSSGFDSG 691

Mouse   665 -DPFHSSSSDDFFKKQTKNDPFTSDPFTKNPSLPSKLDPFESSDPFSSSSISSKGSDPFGTLD-P 727
             |.|..|.:...| .||:.|||.||.|..|.|  :.:.|....|.|        |||||..|. |
  Fly   692 FDAFGQSGAGSAF-GQTQRDPFGSDAFAANKS--NAITPEPGKDDF--------GSDPFAALHAP 745

Mouse   728 FGSSSFSSAEGFADFSQMSKPPPSGPFSSSLGGTGFSDDPFKSKQDTPALPPKKP--APPRPKPP 790
            .|.....|..     :|.|.|||                  :.:..:|||||||.  .||||.||
  Fly   746 TGQGQVLSPN-----AQKSGPPP------------------RPESPSPALPPKKSKVPPPRPAPP 787

Mouse   791 SEA-AAGEKGTVVYTLLGGQSTPVSQLGSSDFPESPDPFQPLGADSGDPFQNK-----KGFGDPF 849
            ..| ..|..|:      ||..      |.:||               |.|.||     .......
  Fly   788 RAAQPTGGFGS------GGGG------GFADF---------------DDFDNKLHHIPSAPSPSA 825

Mouse   850 SGKDPFAPSSSAKPPKTSSSGFAD-FTSFGNEEQ 882
            :...|..|:..|..|..|.|...| ||.|.:..|
  Fly   826 TALSPLPPTLPAPIPVVSGSSLLDSFTLFDDPGQ 859

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eps15l1	XP_006509607.1	EH	13..103	CDD:197477	47/85 (55%)
		EH	121..200	CDD:197477	45/78 (58%)
		EH	266..362	CDD:197477	59/98 (60%)
		COG4372	363..>594	CDD:443500	72/247 (29%)
Eps-15	NP_611965.2	EH	16..82	CDD:238009	42/65 (65%)
		EH	126..215	CDD:197477	50/88 (57%)
		EH	307..402	CDD:197477	58/95 (61%)
		SMC_prok_B	<423..>632	CDD:274008	66/208 (32%)