DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Epm2a and puc

DIOPT Version :9

Sequence 1:	NP_034276.2	Gene:	Epm2a / 13853	MGIID:	1341085	Length:	330	Species:	Mus musculus
Sequence 2:	NP_524273.1	Gene:	puc / 40958	FlyBaseID:	FBgn0243512	Length:	476	Species:	Drosophila melanogaster

Alignment Length:	157	Identity:	31/157 - (19%)
Similarity:	58/157 - (36%)	Gaps:	30/157 - (19%)

- Green bases have known domain annotations that are detailed below.

Mouse   146 FNIAGHQAMHYSRILPNIWLGSCPRQLEHVTIKLKHELGVTAVMNFQTEWDIIQNSSGCNRYPEP 210
            ::|..|.|   |.:.|::.||: .|..:..:     .:|...|:|...:   ..|.|..
  Fly   127 YDIETHPA---SPVFPHLLLGN-GRDADDPS-----SVGANCVLNVTCQ---SPNESHL------ 173

Mouse   211 MTPDTMMKLYKEEGLSYIWMPTPDMSTEGRVQMLPQAVCLLHALLENGHTVYVHCNAGVGRSTAA 275
                        :||.|:.:|..|...:...|...:|...:....:.|..|.:||:||:.||...
  Fly   174 ------------QGLKYMQIPASDTPHQNIKQYFQEAYDFIEDARKTGSRVLLHCHAGISRSATI 226

Mouse   276 VCGWLHYVIGWNLRKVQYFIMAKRPAV 302
            ...::......:|.:....:...||.:
  Fly   227 AIAYVMRYKSLSLLEAYKLVKVARPII 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Epm2a	NP_034276.2	CBM20_laforin	1..128	CDD:99881
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:O95278	102..106
		PTPc	157..303	CDD:304379	28/146 (19%)
		Glucan phosphatase signature motif CXAGXGR. /evidence=ECO:0000250\|UniProtKB:O95278	265..271		3/5 (60%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:O95278	266..271		2/4 (50%)
puc	NP_524273.1	DSPc	133..267	CDD:238073	29/151 (19%)
puc	NP_524273.1	CDC14	<193..272	CDD:225297	13/61 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1716
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900